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LFHP-1c
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Purity:98.07%
LFHP-1c
Catalog No. T78141Cas No. 2102347-47-5
LFHP-1c is a novel PGAM5 inhibitor that shows neuroprotective activity in an ischemic stroke model, preventing BBB destruction after transient middle cerebral artery occlusion (tMCAO) in rats.LFHP-1c can be used to study cerebral ischemic stroke.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $198 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | LFHP-1c is a novel PGAM5 inhibitor that shows neuroprotective activity in an ischemic stroke model, preventing BBB destruction after transient middle cerebral artery occlusion (tMCAO) in rats.LFHP-1c can be used to study cerebral ischemic stroke. |
| In vitro | In primary rat brain microvascular endothelial cells (rBMECs), LFHP-1c (2 μmol/L; 1 hour) binds to PGAM5, facilitating the nuclear translocation of NRF2[1]. |
| In vivo | In the nonhuman primate Macaca fascicularis model with tMCAO, LFHP-1c (3 mg/kg, 1 mL/kg; intravenous injection; at 4 h, 1, 2, 3, 4, 5, 6, and 7 days after tMCAO onset) reduced infarct volume, brain edema, and neurological deficits in the transient MCAO model in M. fascicularis[1]. |
| Molecular Weight | 873.13 |
| Formula | C55H64N6O4 |
| Cas No. | 2102347-47-5 |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 80 mg/mL (91.62 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
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