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GNF362
GNF362 is an orally available, selective and potent inhibitor of inositol trisphosphate 3'kinase B (ITPKB), inhibits Itpka and Itpkc, overcomes TMZ chemoresistance, and selectively deletes donor allogeneic reactive T-cells.GNF362 reverses the migratory stimulatory effects of ITPKA overexpression.
Catalog No. T11446Cas No. 1003019-41-7
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GNF362
Catalog No. T11446Alias GNF-362, GNF 362Cas No. 1003019-41-7
GNF362 is an orally available, selective and potent inhibitor of inositol trisphosphate 3'kinase B (ITPKB), inhibits Itpka and Itpkc, overcomes TMZ chemoresistance, and selectively deletes donor allogeneic reactive T-cells.GNF362 reverses the migratory stimulatory effects of ITPKA overexpression.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $399 | 5 days |
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Product Introduction
Bioactivity
Chemical Properties
| Description | GNF362 is an orally available, selective and potent inhibitor of inositol trisphosphate 3'kinase B (ITPKB), inhibits Itpka and Itpkc, overcomes TMZ chemoresistance, and selectively deletes donor allogeneic reactive T-cells.GNF362 reverses the migratory stimulatory effects of ITPKA overexpression. |
| In vitro | GNF362 blocks Ins(1,3,4,5)P4 production, enhances antigen receptor-mediated Ca2+ responses, and leads to apoptosis of activated T cells in an Itpkb-dependent manner, while augmenting SOC responses with an EC50 value of 12 nM[1]. |
| In vivo | In the Lewis rat antigen-induced arthritis (rAIA) model, GNF362 (6 or 20 mg/kg; oral administration; twice daily; 21 days) reduced knee joint swelling in rats by 47% in the 20 mg/kg treatment group and by 34% in the 6 mg/kg treatment group [1]. |
| Alias | GNF-362, GNF 362 |
| Molecular Weight | 426.44 |
| Formula | C22H21F3N6 |
| Cas No. | 1003019-41-7 |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||||||||||||
| Solubility Information | Ethanol: 40 mg/mL (93.80 mM) DMSO: 80 mg/mL (187.60 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
Ethanol/DMSO
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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