store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Apicidin (OSI 2040) is a histone deacetylase (HDAC) inhibitor with antiparasitic activity and antiproliferative activity.Apicidin attenuates memory deficits, inhibits cell growth and proliferation, and induces apoptosis and autophagy by decreasing Abeta load in APP/PS1 mice, and can be used to study leukemia.
Pack Size | Availability | Price/USD | Quantity |
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2 mg | In stock | $ 426.00 |
Description | Apicidin (OSI 2040) is a histone deacetylase (HDAC) inhibitor with antiparasitic activity and antiproliferative activity.Apicidin attenuates memory deficits, inhibits cell growth and proliferation, and induces apoptosis and autophagy by decreasing Abeta load in APP/PS1 mice, and can be used to study leukemia. |
In vitro | Apicidin (0.1-10 μM, 24 h) inhibits the viability of AT-84 cells in a dose-dependent manner, with concentrations ≥1 μM leading to a significant decrease in viability[1]. |
In vivo | In the mouse tumor model, at the end of 14 days, Apicidin (5 mg/kg, intraperitoneal injection, once daily) significantly inhibited tumor growth by up to 46% compared to the control group[1]. |
Synonyms | OSI 2040 |
Molecular Weight | 623.78 |
Formula | C34H49N5O6 |
CAS No. | 183506-66-3 |
store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 10 mg/mL (16.03 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Apicidin 183506-66-3 Apoptosis Autophagy Chromatin/Epigenetic DNA Damage/DNA Repair HDAC OSI-2040 OSI 2040 OSI2040 inhibitor inhibit