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HDAC

Histone deacetylases (HDAC) are a class of enzymes that remove acetyl groups (O=C-CH3) from an ε-N-acetyl lysine amino acid on a histone, allowing the histones to wrap the DNA more tightly. This is important because DNA is wrapped around histones, and DNA expression is regulated by acetylation and de-acetylation. Its action is opposite to that of histone acetyltransferase. HDAC proteins are now also called lysine deacetylases (KDAC), to describe their function rather than their target, which also includes non-histone proteins.
Cat. No. Product name CAS No. Purity Chemical Structure
T10602 BRD 4354 ditrifluoroacetate T10602 98%
BRD 4354 (ditrifluoroacetate) is a moderately potent inhibitor of HDAC5 and HDAC9 (IC50s: 0.85 and 1.88 μM).
T16805 RTS-V5 2285346-31-6 98%
RTS-V5 is a dual inhibitor of HDAC/proteasome (IC50s: 6.9, 18, 15, 0.27, 0.53 μM for HDAC1, HDAC2, HDAC3, HDAC6, HDAC8, respectively).
T16415 Oxamflatin 151720-43-3 98%
Oxamflatin is an effective inhibitor of HDAC (IC50: 15.7 nM).
T16288 Neuropathiazol 880090-88-0 98%
Neuropathiazol causes neuronal differentiation of adult hippocampal neural progenitor cells.
T17028 Tefinostat 914382-60-8 98%
Tefinostat is a monocyte/macrophage-targeted pan HDAC inhibitor. That is cleaved into active acid CHR-2847 by the intracellular esterase human carboxylesterase-1...
TN4288 Isoferulic acid 25522-33-2 98%
Isoferulic acid is an effective natural antioxidant in both lipid and aqueous media, it may be a new promising anti-glycation agent for the prevention of diabeti...
T11329 FT895 2225728-57-2 98%
FT895 is a selective and potent selective HDAC11 inhibitor with an IC50 of 3 nM.
T14936 Ivaltinostat 936221-33-9 98%
CG-200745 is a potent inhibitor of HDAC. CG200745 induces apoptosis and also inhibits the deacetylation of histone H3 and tubulin.
T11544 HDACs/mTOR Inhibitor 1 2271413-06-8 98%
HDACs/mTOR Inhibitor 1 is a dual HDACs and mammalian target of Rapamycin (mTOR) target inhibitor for treating hematologic malignancies (IC50s: 0.19 nM, 1.8 nM, 1...
T15605 JAK/HDAC-IN-1 2284621-75-4 98%
JAK/HDAC-IN-1 is an effective JAK2/HDAC dual inhibitor (IC50s: 4 and 2 nM for JAK2 and HDAC). It also shows antiproliferative and proapoptotic activities in seve...
T10864 Corin 1808113-09-8 98%
Corin is an irreversible inhibitor of HDAC1(IC50 = 147 nM) and LSD1(Ki = 110 nM).
T2S0606 Bakkenolide A 19906-72-0 98%
Bakkenolide A has antifeedant and growth inhibitory effects on neonate variegated cutworms, it inhibits leukemia by regulation of HDAC3 and PI3K/Akt-related sign...
T11543 HDAC-IN-5 1314890-51-1 98%
HDAC-IN-5 is a histone deacetylase (HDAC) inhibitor.
T11706 JAK1-IN-7 2241039-81-4 98%
JAK1-IN-7 is a Janus-associated kinase 1 (JAK1) inhibitor, has an anti-inflammatory effect.
T11542 HDAC-IN-4 1252003-13-6 98%
HDAC-IN-4 is a selective HDAC6 and HDAC10 inhibitor (pIC50s: 7.2 and 6.8 in BRET assay) with antitumoral activity.
T6637 Resminostat 864814-88-0 98%
Resminostat is an orally bioavailable inhibitor of histone deacetylases (HDACs) with potential antineoplastic activity.
T14305 Apicidin 183506-66-3 98%
Apicidin (OSI 2040) is a fungal metabolite, acts as a histone deacetylase (HDAC) inhibitor. It has antiparasitic activity and a broad spectrum antiproliferative ...
T14947 CHDI-390576 1629729-98-1 98%
CHDI-390576 is a CNS penetrant class IIa HDAC inhibitor (IC50s: 54 nM, 60 nM, 31 nM, 50 nM for class IIa HDAC4, HDAC5, HDAC7, HDAC9). It shows >500-fold selectiv...
T21715 BRD6688 1404562-17-9 98%
BRD6688 is a selective HDAC2 inhibitor that acts by enhancing the learning and memory processes
T25175 BRD 9757 1423058-85-8 98%
BRD 9757 is a selective inhibitor of HDAC6 (IC50 = 30 nM).
BRD 4354 ditrifluoroacetate
T10602
BRD 4354 (ditrifluoroacetate) is a moderately potent inhibitor of HDAC5 and HDAC9 (IC50s: 0.85 and 1.88 μM).
RTS-V5
T16805
RTS-V5 is a dual inhibitor of HDAC/proteasome (IC50s: 6.9, 18, 15, 0.27, 0.53 μM for HDAC1, HDAC2, HDAC3, HDAC6, HDAC8, respectively).
Oxamflatin
T16415
Oxamflatin is an effective inhibitor of HDAC (IC50: 15.7 nM).
Neuropathiazol
T16288
Neuropathiazol causes neuronal differentiation of adult hippocampal neural progenitor cells.
Tefinostat
T17028
Tefinostat is a monocyte/macrophage-targeted pan HDAC inhibitor. That is cleaved into active acid CHR-2847 by the intracellular esterase human carboxylesterase-1...
Isoferulic acid
TN4288
Isoferulic acid is an effective natural antioxidant in both lipid and aqueous media, it may be a new promising anti-glycation agent for the prevention of diabeti...
FT895
T11329
FT895 is a selective and potent selective HDAC11 inhibitor with an IC50 of 3 nM.
Ivaltinostat
T14936
CG-200745 is a potent inhibitor of HDAC. CG200745 induces apoptosis and also inhibits the deacetylation of histone H3 and tubulin.
HDACs/mTOR Inhibitor 1
T11544
HDACs/mTOR Inhibitor 1 is a dual HDACs and mammalian target of Rapamycin (mTOR) target inhibitor for treating hematologic malignancies (IC50s: 0.19 nM, 1.8 nM, 1...
JAK/HDAC-IN-1
T15605
JAK/HDAC-IN-1 is an effective JAK2/HDAC dual inhibitor (IC50s: 4 and 2 nM for JAK2 and HDAC). It also shows antiproliferative and proapoptotic activities in seve...
Corin
T10864
Corin is an irreversible inhibitor of HDAC1(IC50 = 147 nM) and LSD1(Ki = 110 nM).
Bakkenolide A
T2S0606
Bakkenolide A has antifeedant and growth inhibitory effects on neonate variegated cutworms, it inhibits leukemia by regulation of HDAC3 and PI3K/Akt-related sign...
HDAC-IN-5
T11543
HDAC-IN-5 is a histone deacetylase (HDAC) inhibitor.
JAK1-IN-7
T11706
JAK1-IN-7 is a Janus-associated kinase 1 (JAK1) inhibitor, has an anti-inflammatory effect.
HDAC-IN-4
T11542
HDAC-IN-4 is a selective HDAC6 and HDAC10 inhibitor (pIC50s: 7.2 and 6.8 in BRET assay) with antitumoral activity.
Resminostat
T6637
Resminostat is an orally bioavailable inhibitor of histone deacetylases (HDACs) with potential antineoplastic activity.
Apicidin
T14305
Apicidin (OSI 2040) is a fungal metabolite, acts as a histone deacetylase (HDAC) inhibitor. It has antiparasitic activity and a broad spectrum antiproliferative ...
CHDI-390576
T14947
CHDI-390576 is a CNS penetrant class IIa HDAC inhibitor (IC50s: 54 nM, 60 nM, 31 nM, 50 nM for class IIa HDAC4, HDAC5, HDAC7, HDAC9). It shows >500-fold selectiv...
BRD6688
T21715
BRD6688 is a selective HDAC2 inhibitor that acts by enhancing the learning and memory processes
BRD 9757
T25175
BRD 9757 is a selective inhibitor of HDAC6 (IC50 = 30 nM).
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