T0431 |
PCI24781 |
PCI-24781 (Abexinostat) is a new pan-HDAC inhibitor mainly targeting HDAC1 (Ki: 7 nM), also have moderate inhibitory for HDACs 2, 3, 6, and 10 and greater than ...
|
T10244 |
ACY-1083 |
ACY-1083 is a selective and brain-penetrating HDAC6 inhibitor (IC50: 3 nM). It is 260-fold more selective for HDAC6 than all other classes of HDAC isoforms. ACY...
|
T10245 |
ACY-957 |
ACY-957 is an orally active and selective inhibitor of HDAC1 and HDAC2 (IC50s: 7 nM, 18 nM, and 1300 nM against HDAC1/2/3) and shows no inhibition on HDAC4/5/6/...
|
T10255 |
AES-135 |
AES-135 is a potent HDAC inhibitor, inhibits HDAC3, HDAC6, HDAC11 (IC50s: 654, 190, and 636 nM) with anti-tumor activity. |
T10602 |
BRD 4354 ditrifluoroacetate |
BRD 4354 (ditrifluoroacetate) is a moderately potent inhibitor of HDAC5 and HDAC9 (IC50s: 0.85 and 1.88 μM). |
T10602L |
BRD 4354 |
BRD 4354 is an inhibitor of HDAC5 and HDAC9 (IC50s: 0.85 and 1.88 μM for HDAC5 and HDAC9). |
T10603 |
BRD-6929 |
BRD-6929 is a selective, brain-penetrant HDAC1 and HDAC2 inhibitor (IC50: 1 and 8 nM). |
T10777 |
CG347B |
CG347B is a selective inhibitor of HDAC6. |
T1083 |
Theophylline |
Theophylline is a methyl xanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and central nervous system stimulant ac...
|
T1083L |
Theophylline monohydrate |
Theophylline appears to inhibit phosphodiesterase and prostaglandin production, regulate calcium flux and intracellular calcium distribution, and antagonize ade...
|
T10883 |
CRA-026440 |
CRA-026440 is a potent, broad-spectrum HDAC inhibitor (Kis: 4, 14, 11, 15, 7, and 20 nM for HDAC1, HDAC2, HDAC3, HDAC6, HDAC8, and HDAC10). |
T11329 |
FT895 |
FT895 is a selective and potent selective HDAC11 inhibitor with an IC50 of 3 nM. |
T11542 |
HDAC-IN-4 |
HDAC-IN-4 is a selective HDAC6 and HDAC10 inhibitor (pIC50s: 7.2 and 6.8 in BRET assay) with antitumoral activity. |
T11543 |
HDAC-IN-5 |
HDAC-IN-5 is a histone deacetylase (HDAC) inhibitor. |
T11544 |
HDACs/mTOR Inhibitor 1 |
HDACs/mTOR Inhibitor 1 is a dual HDACs and mammalian target of Rapamycin (mTOR) target inhibitor for treating hematologic malignancies (IC50s: 0.19 nM, 1.8 nM, ...
|
T11706 |
JAK1-IN-7 |
JAK1-IN-7 is a Janus-associated kinase 1 (JAK1) inhibitor, has an anti-inflammatory effect. |
T13996 |
1-Naphthohydroxamic acid |
1-Naphthohydroxamic acid (Compound 2) is a potent and selective HDAC8 inhibitor with an IC50 of 14 μM, and it is more selectively for HDAC8 than class I HDAC1 ...
|
T14305 |
Apicidin |
Apicidin (OSI 2040) is a fungal metabolite, acts as a histone deacetylase (HDAC) inhibitor. It has antiparasitic activity and a broad spectrum antiproliferative...
|
T14936 |
CG-200745 |
CG-200745 is a potent inhibitor of HDAC. CG200745 induces apoptosis and also inhibits the deacetylation of histone H3 and tubulin. |
T14947 |
CHDI-390576 |
CHDI-390576 is a CNS penetrant class IIa HDAC inhibitor (IC50s: 54 nM, 60 nM, 31 nM, 50 nM for class IIa HDAC4, HDAC5, HDAC7, HDAC9). It shows >500-fold selecti...
|
T1535 |
Sodium Phenylbutyrate |
Sodium Phenylbutyrate, a transcriptional regulator, reversibly inhibits class I and II histone deacetylases (HDACs )resulting in a global increase in gene expre...
|
T1583 |
VorinostatHOT |
Vorinostat is a pan-inhibitor of Histone Deacetylase with antineoplastic activity (IC50: ~10 nM). |
T1602 |
Valproic acid sodium salt |
Valproate Sodium is the sodium salt form of valproic acid with anti-epileptic activity. Valproate sodium is converted into its active form, valproate ion, in bl...
|
T16153 |
MS4078 |
MS4078 is an anaplastic lymphoma kinase (ALK) PROTAC. It has a Kd of 19 nM for binding affinity to ALK. |
T16288 |
Neuropathiazol |
Neuropathiazol is a synthetic small molecule. It also causes neuronal differentiation of adult hippocampal neural progenitor cells. |
T16415 |
Oxamflatin |
Oxamflatin is an effective inhibitor of HDAC (IC50: 15.7 nM). |
T16729 |
Remetinostat |
Remetinostat is a hydroxamic acid-based inhibitor of histone deacetylase enzymes. It is under development for the treatment of cutaneous T-cell lymphoma. |
T16805 |
RTS-V5 |
RTS-V5 is a dual inhibitor of HDAC/proteasome (IC50s: 6.9, 18, 15, 0.27, 0.53 μM for HDAC1, HDAC2, HDAC3, HDAC6, HDAC8, respectively). |
T16936 |
SS-208 |
SS-208 is a selective HDAC6 inhibitor (IC50: 12 nM). SS-208 has anti-tumor activity in melanoma. |
T16962 |
SW-100 |
SW-100 is a selective histone deacetylase 6 inhibitor (IC50: 2.3 nM). It also shows at least 1000-fold selectivity for HDAC6 relative to all other HDAC isozymes...
|
T17028 |
Tefinostat |
Tefinostat is a monocyte/macrophage-targeted pan HDAC inhibitor. That is cleaved into active acid CHR-2847 by the intracellular esterase human carboxylesterase-...
|
T1762 |
RGFP 966HOT |
RGFP966 is an HDAC3 inhibitor (IC50: 0.08 μM) and does not affect other HDACs at concentrations up to 15 µM. |
T1819 |
Nexturastat A |
Nexturastat A is an effective and specific HDAC6 inhibitor (IC50: 5 nM). Its selectivity is >190-fold than other HDACs. |
T1852 |
Belinostat |
Belinostat is a novel hydroxamic acid-type histone deacetylase (HDAC) inhibitor with antineoplastic activity. Belinostat targets HDAC enzymes, thereby inhibitin...
|
T1857 |
TMP269 |
TMP269 is an effective, specific class IIa HDAC inhibitor for HDAC4 (IC50: 157 nM), HDAC5 (IC50: 97 nM), HDAC7 (IC50: 43 nM), and HDAC9 (IC50: 23 nM), respectiv...
|
T1888 |
CI994 |
Tacedinaline (CI994) is a selective class I HDAC inhibitor with potential antineoplastic activity. |
T1890 |
Pracinostat |
Pracinostat is a novel HDAC inhibitor with improved in vivo properties compared to other HDAC inhibitors currently in Clinicalal trials, allowing oral dosing. D...
|
T1966 |
Tubastatin A |
Tubastatin A is an effective and specific HDAC6 inhibitor (IC50: 15 nM, in a cell-free assay). Its selectivity is 1000-fold against all the other isozymes excep...
|
T19687 |
Phenylethyl isothiocyanate |
Phenylethyl isothiocyanate is an HDAC inhibitor. It potentially for the treatment of benign prostatic hypertrophy. |
T1983 |
CAY10603 |
CAY10603 is a potent and selective inhibitor of HDAC6. |
T2023 |
MC1568 |
MC1568 is a specific HDAC inhibitor for maize HD1-A (IC50: 100 nM, in a cell-free assay). It is 34-fold more selective for HD1-A than HD1-B. |
T2025 |
Chidamide |
Chidamide(CS055; HBI-8000) is a class I HDAC inhibitor with IC50s of 95/160/67/733 nM for HDAC1/2/3/8; also inhibits HDAC10/11(IC50=78/432 nM); no inhibition on...
|
T2078 |
PI3K/HDAC Inhibitor |
CUDC-907 is an orally bioavailable inhibitor of both phosphoinositide 3-kinase (PI3K) class I and pan-histone deacetylase (HDAC) enzymes, with potential antineo...
|
T2140 |
Parthenolide |
(-)-Parthenolide, an inhibitor of the Nuclear Factor-κB Pathway, also promotes the ubiquitination of MDM2 and activates p53 cellular functions. |
T2157 |
Histone Deacetylase Inhibitor III |
M344 is a potent HDAC inhibitor with IC50 of 100 nM and able to induce cell differentiation. |
T2205 |
Theophylline-7-acetic acid |
Theophylline-7-acetic acid, a stimulant drug of the xanthine chemical class, acts as an adenosine receptor antagonist. It is combined with diphenhydramine in th...
|
T2266 |
SantacruzaMate A |
Santacruzamate A (CAY10683) is a potent and selective HDAC inhibitor. |
T2294 |
BG45 |
BG45 is an HDAC I type inhibitor with IC50 of 289 nM, 2.0 μM, 2.2 μM and >20 μM for HDAC3/1/2/6 in cell-free assays, respectively. |
T2383 |
PanobinostatHOT |
Panobinostat is a potent inhibitor of all HDACs (Kis: 0.6-31 nM for HDAC1-11). |
T2430 |
HPOB |
HPOB is an effective and specific HDAC6 inhibitor (IC50: 56 nM), >30-fold selectivity over other HDACs. |
T2454 |
Dacinostat |
LAQ824 (Dacinostat) is a novel HDAC inhibitor with IC50 of 32 nM and is an activator of the p21 promoter. |
T2489 |
Rocilinostat |
Ricolinostat is an orally bioavailable, specific inhibitor of histone deacetylase 6 (HDAC6) with potential antineoplastic activity. |
T2512 |
MocetinostatHOT |
Mocetinostat is an orally available HDAC inhibitor with most potency for HDAC1 (IC50: 0.15 μM), 2- to 10- fold selectivity against HDAC2/3/11. |
T2S0606 |
Bakkenolide A |
Bakkenolide A has antifeedant and growth inhibitory effects on neonate variegated cutworms, it inhibits leukemia by regulation of HDAC3 and PI3K/Akt-related sig...
|
T3108 |
CUDC101 |
CUDC-101 is a potent inhibitor of HDAC, EGFR and HER2 with IC50s of 4.4, 2.4 and 15.7 nM, respectively. |
T3193 |
Pimelic diphenylamide 106 |
Pimelic diphenylamide 106 is a slow, tight-binding inhibitor of class I HDAC (with IC50 values of 150 nM , 760 nM and 370 nM for HDAC 1, 2, and 3, respectively)...
|
T3199 |
PTACH |
PTACH (NCH-51) is a SAHA-based inhibitor of human HDAC. It can potently inhibit the growth of various human Y cells (EC50: 1 to 10 μM). |
T3204 |
BML210 |
BML-210 is a new-type HDAC inhibitor. |
T3205 |
UF010 |
UF010 is a potent and selective HADC inhibitor with IC50 ~0.06 μM, 0.1 μM, 0.5 μM and 1.5 μM for HDACs 3, 2, 1 and 8, respectively. |
T3206 |
PAOA |
An effective Histone Deacetylase Inhibitor. |
T3358 |
ITSA1 |
ITSA-1 is membrane permeable and specifically suppresses TSA inhibition of HDAC (histone deacetylase), but shows no activity towards other HDAC inhibitors. |
T3509 |
ACY738 |
ACY-738 demonstrates inhibitory activity against recombinant HDAC6 (IC50: 1.7 nM), with respective average selectivity over class I HDACs being 100-fold. |
T3516 |
Minomustine |
EDO-S101 is a pan HDAC inhibitor with IC50 values of 9, 9 and 25 nM for HDAC1, HDAC2 and HDAC3 , respectively. |
T3661 |
Citarinostat |
ACY-241, also known as Citarinostat, is a potent, selective and orally available histone deacetylase (HDAC) inhibitor, with potential antineoplastic activity. U...
|
T3753 |
Sinapinic Acid |
Sinapic acid protects the rat liver from CCl4-induced inflammation, most likely by acting as a free radical scavenger and modulator of NF-κB p65 activation and...
|
T3753 |
Sinapinic Acid |
Sinapic acid protects the rat liver from CCl4-induced inflammation, most likely by acting as a free radical scavenger and modulator of NF-κB p65 activation and...
|
T3878 |
Raddeanin A |
Raddeanin A has moderate inhibitory activity against histone deacetylases (HDACs). Raddeanin A has high antiangiogenic potency, antitumor activity. |
T3937 |
Methyl L-histidinate dihydrochloride |
Inhibition of histidine decarboxylase in Sprague-Dawley rat stomach assessed as decrease in 14CO2 production with activty value of 1.8 μM |
T3983 |
TMP 195 |
TMP195 is a selective class IIa histone deacetylase (HDAC) inhibitor. |
T4370 |
Resminostat hydrochloride |
Resminostat hydrochloride is an effective inhibitor of HDAC1/HDAC3/HDAC6 (IC50: 42.5/50.1/71.8 nM), respectively, and shows less potent activities against HDAC8...
|
T4389 |
SR4370 |
SR-4370 is an HDAC inhibitor. SR-4370 exhibited IC50 values of 0.5 μM, 0.1 μM and 0.06 μM towards HDAC1, HDAC2 and HDAC3, resp. SR-4370 is reported ...
|
T4477 |
4SC-202 tosylate |
4SC-202 is a selective inhibitor of class I HDAC for HDAC1/2/3 (IC50: 1.20/1.12/0.57 μM). It also displays inhibitory activity against Lysine-specific demethyl...
|
T4481 |
Tucidinostat |
Tucidinostat is an effective and orally bioavailable HDAC enzymes class I (HDAC1/2/3) and class IIb (HDAC10) inhibitor, with IC50s of 95, 160, 67 and 78 nM, les...
|
T5332 |
TH34 |
TH34 is an HDAC6/8/10 inhibitor (IC50s: 4.6/1.9/7.7 μM). It shows high selectivity over HDAC1/2/3. |
T5347 |
CXD-101 |
CXD101 is a novel class I-selective HDACi (HDAC1 (IC50 : 63nM), HDAC2 (IC50 :570nM), HDAC3 (IC50 :550nM)). CXD101 has no activity against HDAC class II |
T5631 |
SIS17 |
SIS17 is a potent and selective HDAC 11 inhibitor with an IC50 value of 0.83 μM. SIS17, is active in cells and inhibited the demyristoylation of a known HDAC11...
|
T5830 |
SKLB-23bb |
SKLB-23bb is an orally bioavailable HDAC6-selective inhibitor and also has microtubule-disrupting ability. |
T5886 |
Benzenebutyric acid |
Benzenebutyric acid is an inhibitor of HDAC,and is an antineoplastic agent. |
T6006 |
Romidepsin |
Romidepsin is an intravenously administered histone deacetylase inhibitor and antineoplastic agent that is approved for use in refractory or relapsed cutaneous ...
|
T6055 |
Quisinostat |
Quisinostat (JNJ-26481585) is a novel second-generation HDAC inhibitor with highest potency for HDAC1 with IC50 of 0.11 nM, modest potent to HDACs 2, 4, 10, and...
|
T6061 |
LMK235 |
LMK-235 is a potent HDAC inhibitor, and is used in cancer research. |
T6161 |
Tubastatin A HCl |
Tubastatin A HCl is an effective and specific HDAC6 inhibitor (IC50: 15 nM). It has selectivity (>1000-fold) against all other isozymes except HDAC8 (>57-fold). |
T6233 |
EntinostatHOT |
Entinostat (MS-275) is an inhibitor of HDACs that inhibits HDAC1 and HDAC3 (IC50s: 0.18/0.74 μM). |
T6270 |
Trichostatin A |
Trichostatin A is a natural derivative of dienohydroxamic acid isolated from species of the bacterial genus Streptomyces. Trichostatin A (TSA) reversibly and sp...
|
T6279 |
Givinostat hydrochloride monohydrate |
Givinostat hydrochloride monohydrate is an HDAC inhibitor. |
T6325 |
PCI34051 |
PCI-34051 is an effective and selective HDAC8 inhibitor (IC50: 10 nM). |
T6327 |
Tubacin |
Tubacin is a highly potent and selective, reversible, cell-permeable HDAC6 inhibitor with an IC50 of 4 nM, approximately 350-fold selectivity over HDAC1. |
T6362 |
4SC202 |
4SC-202 is a selective class I HDAC inhibitor with IC50 of 1.20 μM, 1.12 μM, and 0.57 μM for HDAC1, HDAC2, and HDAC3, respectively. Also displays inhibitory ...
|
T6392 |
AR42 |
AR-42 is an HDAC inhibitor (IC50: 30 nM). |
T6421 |
BRD73954 |
BRD73954, an effective and specific HDAC inhibitor, which is with IC50 of 36 nM and 120 nM for HDAC6 and HDAC8, respectively. |
T6474 |
Divalproex Sodium |
Divalproex Sodium binds to and inhibits gamma-aminobutyric acid (GABA) transaminase and its anticonvulsant activity may be exerted by increasing brain concentra...
|
T6481 |
Droxinostat |
Droxinostat is a selective inhibitor of HDAC, mostly for HDACs 6 and 8 with IC50 of 2.47 μM and 1.46 μM, greater than 8-fold selective against HDAC3 and no in...
|
T6639 |
RG2833 |
RG2833 (RGFP109), a brain-penetrant HDAC inhibitor, is with IC50 of 60 nM and 50 nM for HDAC1 and HDAC3, respectively. |
T6695 |
Tasquinimod |
Tasquinimod is a quinoline-3-carboxamide linomide analog with antiangiogenic and potential antineoplastic activities. Tasquinimod has been shown to decrease blo...
|
T6865 |
Quisinostat 2HCl |
Quisinostat (JNJ-26481585) 2HCl is a novel second-generation HDAC inhibitor with highest potency for HDAC1 with IC50 of 0.11 nM in a cell-free assay, modest pot...
|
T6980 |
Scriptaid |
Scriptaid is an inhibitor of HDAC, and has a greater effect on acetylated H4 than H3. |
T7064 |
Valproic Acid |
Valproic Acid is a branched chain fatty acid which potentially enhances central GABAergic neurotransmission and inhibits Na+ channels. Currently, the various mo...
|
T7082 |
HDAC8-IN-1 |
MDK-7933 (HDAC8-IN-1) is a HDAC8 inhibitor with an IC50 of 27.2 nM in cancer cell lines. MDK-7933 shows antiproliferative effects toward several human lung canc...
|
T7385 |
WT-161 |
WT161 is a potent and selective inhibitor of HDAC6 (IC50:0.40 nM). |
T7664 |
Pyroxamide |
Pyroxamide is an histone deacetylases (HDACs) inhibitor with antineoplastic properties ( HDAC1;IC50: 0.1-0.2 μM). |
T7691 |
NSC 3852 |
NSC 3852 is a potent inhibitor of histone deacetylase. |
T8233 |
BRD3308 |
BRD3308 is a highly selective inhibitor of HDAC3(IC50 of 54 nM), attenuating PE-mediated phosphorylation of ERK but not JNK. |
T8480 |
Tenovin-6 Hydrochloride |
Tenovin-6 Hydrochloride is an SIRT1, SIRT2 and HDAC8 inhibitor(IC50s of 21 μM, 10 μM, and 67 μM for SirT1, SirT2, and SirT3, respectively), and is also a pot...
|
T8508 |
HDAC-IN-3 |
HDAC-IN-3 is a potent histone deacetylase (HDAC) inhibitor, and treatment chronic inflammatory disorders. |
T8517 |
PXD-101 |
Belinostat is an inhibitor of hydroxamic acid-type histone deacetylase (HDAC, IC50 of 27 nM in HeLa cell extracts),and with antineoplastic activity. |
TN4288 |
Isoferulic acid |
Isoferulic acid is an effective natural antioxidant in both lipid and aqueous media, it may be a new promising anti-glycation agent for the prevention of diabet...
|
TQ0074 |
ACY-775 |
ACY-775 is an effective and specific inhibitor of HDAC6 (IC50: 7.5 nM). |