HDAC

Histone deacetylases (HDAC) are a class of enzymes that remove acetyl groups (O=C-CH3) from an ε-N-acetyl lysine amino acid on a histone, allowing the histones to wrap the DNA more tightly. This is important because DNA is wrapped around histones, and DNA expression is regulated by acetylation and de-acetylation. Its action is opposite to that of histone acetyltransferase. HDAC proteins are now also called lysine deacetylases (KDAC), to describe their function rather than their target, which also includes non-histone proteins.

Cat. No.	Product name	CAS No.	Purity
T11706	JAK1-IN-7	2241039-81-4	98%
T11706	JAK1-IN-7 is a Janus-associated kinase 1 (JAK1) inhibitor, has an anti-inflammatory effect.
T16415	Oxamflatin	151720-43-3	98%
T16415	Oxamflatin is an effective inhibitor of HDAC (IC50: 15.7 nM).
T16805	RTS-V5	2285346-31-6	98%
T16805	RTS-V5 is a dual inhibitor of HDAC/proteasome (IC50s: 6.9, 18, 15, 0.27, 0.53 μM for HDAC1, HDAC2, HDAC3, HDAC6, HDAC8, respectively).
TN4288	Trans-Isoferulic acid	25522-33-2	98%
TN4288	Isoferulic acid is an effective natural antioxidant in both lipid and aqueous media, it may be a new promising anti-glycation agent for the prevention of diabeti...
T11329	FT895	2225728-57-2	98%
T11329	FT895 is a selective and potent selective HDAC11 inhibitor with an IC50 of 3 nM.
T6637	Resminostat	864814-88-0	98%
T6637	Resminostat is an orally bioavailable inhibitor of histone deacetylases (HDACs) with potential antineoplastic activity.
T10883	CRA-026440	847460-34-8	98%
T10883	CRA-026440 is a potent, broad-spectrum HDAC inhibitor (Kis: 4, 14, 11, 15, 7, and 20 nM for HDAC1, HDAC2, HDAC3, HDAC6, HDAC8, and HDAC10).
T17028	Tefinostat	914382-60-8	98%
T17028	Tefinostat is a monocyte/macrophage-targeted pan HDAC inhibitor. That is cleaved into active acid CHR-2847 by the intracellular esterase human carboxylesterase-1...
T14305	Apicidin	183506-66-3	98%
T14305	Apicidin (OSI 2040) is a fungal metabolite, acts as a histone deacetylase (HDAC) inhibitor. It has antiparasitic activity and a broad spectrum antiproliferative ...
T11544	HDACs/mTOR Inhibitor 1	2271413-06-8	98%
T11544	HDACs/mTOR Inhibitor 1 is a dual HDACs and mammalian target of Rapamycin (mTOR) target inhibitor for treating hematologic malignancies (IC50s: 0.19 nM, 1.8 nM, 1...
T11543	HDAC-IN-5	1314890-51-1	98%
T11543	HDAC-IN-5 is a histone deacetylase (HDAC) inhibitor.
T2S0606	Bakkenolide A	19906-72-0	98%
T2S0606	Bakkenolide A has antifeedant and growth inhibitory effects on neonate variegated cutworms, it inhibits leukemia by regulation of HDAC3 and PI3K/Akt-related sign...
T10602	BRD 4354 ditrifluoroacetate	T10602	98%
T10602	BRD 4354 (ditrifluoroacetate) is a moderately potent inhibitor of HDAC5 and HDAC9 (IC50s: 0.85 and 1.88 μM).
T11542	HDAC-IN-4	1252003-13-6	98%
T11542	HDAC-IN-4 is a selective HDAC6 and HDAC10 inhibitor (pIC50s: 7.2 and 6.8 in BRET assay) with antitumoral activity.
T14936	Ivaltinostat	936221-33-9	98%
T14936	CG-200745 is a potent inhibitor of HDAC. CG200745 induces apoptosis and also inhibits the deacetylation of histone H3 and tubulin.
T14947	CHDI-390576	1629729-98-1	98%
T14947	CHDI-390576 is a CNS penetrant class IIa HDAC inhibitor (IC50s: 54 nM, 60 nM, 31 nM, 50 nM for class IIa HDAC4, HDAC5, HDAC7, HDAC9). It shows >500-fold selectiv...
T27083	Crebinostat	1092061-61-4	98%
T27083	Crebinostat is a potent histone deacetylase (HDAC) inhibitor, inhibiting HDAC1, HDAC2, HDAC3, and HDAC6 with IC50s of 0.7 nM, 1.0 nM, 2.0 nM, and 9.3 nM, respect...
T30579	BRD4097	1550053-19-4	98%
T30579	BRD4097, a negative control in the HDAC1/2/3/8 assay, is a selective histone deacetylase (HDAC3) inhibitor that can be used to protect b-cells and improve insuli...
T9745	Elevenostat	1454902-97-6	98%
T9745	Elevenostat is an HDAC11-selective inhibitor with an IC50 value of 0.235 µM.
T21715	BRD6688	1404562-17-9	98%
T21715	BRD6688 is a selective HDAC2 inhibitor that acts by enhancing the learning and memory processes