HDAC

Histone deacetylases (HDAC) are a class of enzymes that remove acetyl groups (O=C-CH3) from an ε-N-acetyl lysine amino acid on a histone, allowing the histones to wrap the DNA more tightly. This is important because DNA is wrapped around histones, and DNA expression is regulated by acetylation and de-acetylation. Its action is opposite to that of histone acetyltransferase. HDAC proteins are now also called lysine deacetylases (KDAC), to describe their function rather than their target, which also includes non-histone proteins.

Cat No.	product name
T0431	PCI-24781	PCI-24781 (Abexinostat) is a new pan-HDAC inhibitor mainly targeting HDAC1 (Ki: 7 nM), also have moderate inhibitory for HDACs 2, 3, 6, and 10 and greater than ...
T1083	Theophylline	Theophylline is a methyl xanthine derivative from tea with diuretic, smooth muscle relaxant, bronchial dilation, cardiac and central nervous system stimulant ac...
T1083L	Theophylline monohydrate	Theophylline appears to inhibit phosphodiesterase and prostaglandin production, regulate calcium flux and intracellular calcium distribution, and antagonize ade...
T1535	Sodium Phenylbutyrate	Sodium Phenylbutyrate, a transcriptional regulator, reversibly inhibits class I and II histone deacetylases (HDACs )resulting in a global increase in gene expr...
T1583	VorinostatHOT	Vorinostat is a pan-inhibitor of Histone Deacetylase with antineoplastic activity (IC50: ~10 nM).
T1602	Valproic acid sodium salt	Valproate Sodium is the sodium salt form of valproic acid with anti-epileptic activity. Valproate sodium is converted into its active form, valproate ion, in bl...
T1762	RGFP 966HOT	RGFP966 is an HDAC3 inhibitor (IC50: 0.08 μM) and does not affect other HDACs at concentrations up to 15 μM.
T1819	Nexturastat A	Nexturastat A is an effective and specific HDAC6 inhibitor (IC50: 5 nM). Its selectivity is >190-fold than other HDACs.
T1852	Belinostat	Belinostat is a novel hydroxamic acid-type histone deacetylase (HDAC) inhibitor with antineoplastic activity. Belinostat targets HDAC enzymes, thereby inhibitin...
T1857	TMP269	TMP269 is an effective, specific class IIa HDAC inhibitor for HDAC4 (IC50: 157 nM), HDAC5 (IC50: 97 nM), HDAC7 (IC50: 43 nM), and HDAC9 (IC50: 23 nM), respectiv...
T1888	CI994	Tacedinaline (CI994) is a selective class I HDAC inhibitor with potential antineoplastic activity.
T1890	Pracinostat	Pracinostat is a novel HDAC inhibitor with improved in vivo properties compared to other HDAC inhibitors currently in clinical trials, allowing oral dosing. Dat...
T1966	Tubastatin A	Tubastatin A is an effective and specific HDAC6 inhibitor (IC50: 15 nM, in a cell-free assay). Its selectivity is 1000-fold against all the other isozymes excep...
T1983	CAY10603	CAY10603 is a potent and selective inhibitor of HDAC6.
T2023	MC1568	MC1568 is a specific HDAC inhibitor for maize HD1-A (IC50: 100 nM, in a cell-free assay). It is 34-fold more selective for HD1-A than HD1-B.
T2025	Chidamide	Chidamide(CS055; HBI-8000) is a class I HDAC inhibitor with IC50s of 95/160/67/733 nM for HDAC1/2/3/8; also inhibits HDAC10/11(IC50=78/432 nM); no inhibition on...
T2078	CUDC-907	CUDC-907 is an orally bioavailable inhibitor of both phosphoinositide 3-kinase (PI3K) class I and pan-histone deacetylase (HDAC) enzymes, with potential antineo...
T2157	Histone Deacetylase Inhibitor III	M344 is a potent HDAC inhibitor with IC50 of 100 nM and able to induce cell differentiation.
T2205	Theophylline-7-acetic acid	Theophylline-7-acetic acid, a stimulant drug of the xanthine chemical class, acts as an adenosine receptor antagonist. It is combined with diphenhydramine in th...
T2266	SantacruzaMate A	Santacruzamate A (CAY10683) is a potent and selective HDAC inhibitor.
T2294	BG45	BG45 is an HDAC I type inhibitor with IC50 of 289 nM, 2.0 μM, 2.2 μM and >20 μM for HDAC3/1/2/6 in cell-free assays, respectively.
T2383	PanobinostatHOT	Panobinostat is a potent inhibitor of all HDACs (Kis: 0.6-31 nM for HDAC1-11).
T2430	HPOB	HPOB is an effective and specific HDAC6 inhibitor (IC50: 56 nM), >30-fold selectivity over other HDACs.
T2454	Dacinostat	LAQ824 (Dacinostat) is a novel HDAC inhibitor with IC50 of 32 nM and is an activator of the p21 promoter.
T2489	Rocilinostat	Ricolinostat is an orally bioavailable, specific inhibitor of histone deacetylase 6 (HDAC6) with potential antineoplastic activity.
T2512	MocetinostatHOT	Mocetinostat is an orally available HDAC inhibitor with most potency for HDAC1 (IC50: 0.15 μM), 2- to 10- fold selectivity against HDAC2/3/11.
T3108	CUDC-101	CUDC-101 is a potent inhibitor of HDAC, EGFR and HER2 with IC50s of 4.4, 2.4 and 15.7 nM, respectively.
T3193	Pimelic diphenylamide 106	Pimelic diphenylamide 106 is a slow, tight-binding inhibitor of class I HDAC (with IC50 values of 150 nM , 760 nM and 370 nM for HDAC 1, 2, and 3, respectively)...
T3199	PTACH	PTACH (NCH-51) is a SAHA-based inhibitor of human HDAC. It can potently inhibit the growth of various human Y cells (EC50: 1 to 10 μM).
T3204	BML-210	BML-210 is a new-type HDAC inhibitor.
T3205	UF010	UF010 is a potent and selective HADC inhibitor with IC50 ~0.06 μM, 0.1 μM, 0.5 μM and 1.5 μM for HDACs 3, 2, 1 and 8, respectively.
T3206	PAOA	An effective Histone Deacetylase Inhibitor.
T3358	ITSA1	ITSA-1 is membrane permeable and specifically suppresses TSA inhibition of HDAC (histone deacetylase), but shows no activity towards other HDAC inhibitors.
T3509	ACY-738	ACY-738 demonstrates inhibitory activity against recombinant HDAC6 (IC50: 1.7 nM), with respective average selectivity over class I HDACs being 100-fold.
T3516	Minomustine	EDO-S101 is a pan HDAC inhibitor with IC50 values of 9, 9 and 25 nM for HDAC1, HDAC2 and HDAC3 , respectively.
T3661	Citarinostat	ACY-241, also known as Citarinostat, is a potent, selective and orally available histone deacetylase (HDAC) inhibitor, with potential antineoplastic activity. U...
T3878	Raddeanin A	Raddeanin A has moderate inhibitory activity against histone deacetylases (HDACs). Raddeanin A has high antiangiogenic potency, antitumor activity.
T3937	Methyl L-histidinate dihydrochloride	Inhibition of histidine decarboxylase in Sprague-Dawley rat stomach assessed as decrease in 14CO2 production with activty value of 1.8μM
T3983	TMP 195	TMP195 is a selective class IIa histone deacetylase (HDAC) inhibitor.
T6006	Romidepsin	Romidepsin is an intravenously administered histone deacetylase inhibitor and antineoplastic agent that is approved for use in refractory or relapsed cutaneous ...
T6055	Quisinostat	Quisinostat (JNJ-26481585) is a novel second-generation HDAC inhibitor with highest potency for HDAC1 with IC50 of 0.11 nM, modest potent to HDACs 2, 4, 10, and...
T6061	LMK-235	LMK-235 is a potent HDAC inhibitor, and is used in cancer research.
T6161	Tubastatin A HCl	Tubastatin A HCl is an effective and specific HDAC6 inhibitor (IC50: 15 nM). It has selectivity (>1000-fold) against all other isozymes except HDAC8 (>57-fold).
T6233	EntinostatHOT	Entinostat (MS-275) is an inhibitor of HDACs that inhibits HDAC1 and HDAC3 (IC50s: 0.18/0.74 μM).
T6270	Trichostatin A	Trichostatin A is a natural derivative of dienohydroxamic acid isolated from species of the bacterial genus Streptomyces. Trichostatin A (TSA) reversibly and sp...
T6279	Givinostat hydrochloride monohydrate	Givinostat hydrochloride monohydrate is an HDAC inhibitor.
T6325	PCI-34051	PCI-34051 is an effective and selective HDAC8 inhibitor (IC50: 10 nM).
T6327	Tubacin	Tubacin is a highly potent and selective, reversible, cell-permeable HDAC6 inhibitor with an IC50 of 4 nM, approximately 350-fold selectivity over HDAC1.
T6362	4SC-202	4SC-202 is a selective class I HDAC inhibitor with IC50 of 1.20 μM, 1.12 μM, and 0.57 μM for HDAC1, HDAC2, and HDAC3, respectively. Also displays inhibitory ...
T6392	AR-42	AR-42 is an HDAC inhibitor (IC50: 30 nM).
T6421	BRD73954	BRD73954, an effective and specific HDAC inhibitor, which is with IC50 of 36 nM and 120 nM for HDAC6 and HDAC8, respectively.
T6481	Droxinostat	Droxinostat is a selective inhibitor of HDAC, mostly for HDACs 6 and 8 with IC50 of 2.47 μM and 1.46 μM, greater than 8-fold selective against HDAC3 and no in...
T6639	RG2833	RG2833 (RGFP109), a brain-penetrant HDAC inhibitor, is with IC50 of 60 nM and 50 nM for HDAC1 and HDAC3, respectively.
T6695	Tasquinimod	Tasquinimod is a quinoline-3-carboxamide linomide analog with antiangiogenic and potential antineoplastic activities. Tasquinimod has been shown to decrease blo...
T6865	Quisinostat 2HCl	Quisinostat (JNJ-26481585) 2HCl is a novel second-generation HDAC inhibitor with highest potency for HDAC1 with IC50 of 0.11 nM in a cell-free assay, modest pot...
T6980	Scriptaid	Scriptaid is an inhibitor of HDAC，and has a greater effect on acetylated H4 than H3.
T4370	Resminostat hydrochloride	Resminostat hydrochloride is an effective inhibitor of HDAC1/HDAC3/HDAC6 (IC50: 42.5/50.1/71.8 nM), respectively, and shows less potent activities against HDAC8...
T4389	SR-4370	SR-4370 is an HDAC inhibitor. SR-4370 exhibited IC50 values of 0.5 μM, 0.1 μM and 0.06 μM towards HDAC1, HDAC2 and HDAC3, resp. SR-4370 is reported in WO 201...
T7064	Valproic Acid	Valproic Acid is a branched chain fatty acid which potentially enhances central GABAergic neurotransmission and inhibits Na+ channels. Currently, the various mo...
T4477	4SC-202 tosylate	4SC-202 is a selective inhibitor of class I HDAC for HDAC1/2/3 (IC50: 1.20/1.12/0.57 μM). It also displays inhibitory activity against Lysine-specific demethyl...
T4481	Tucidinostat	Tucidinostat is an effective and orally bioavailable HDAC enzymes class I (HDAC1/2/3) and class IIb (HDAC10) inhibitor, with IC50s of 95, 160, 67 and 78 nM, les...
T7082	HDAC8-IN-1	MDK-7933 (HDAC8-IN-1) is a HDAC8 inhibitor with an IC50 of 27.2 nM in cancer cell lines. MDK-7933 shows antiproliferative effects toward several human lung canc...
T5332	TH34	TH34 is an HDAC6/8/10 inhibitor (IC50s: 4.6/1.9/7.7 μM). It shows high selectivity over HDAC1/2/3.
T5347	CXD-101	CXD101 is a novel class I-selective HDACi (HDAC1 (IC50 : 63nM), HDAC2 (IC50 :570nM), HDAC3 (IC50 :550nM)). CXD101 has no activity against HDAC class II
T5631	SIS17	SIS17 is a potent and selective HDAC 11 inhibitor with an IC50 value of 0.83 μM. SIS17, is active in cells and inhibited the demyristoylation of a known HDAC11...
T5830	SKLB-23bb	SKLB-23bb is an orally bioavailable HDAC6-selective inhibitor and also has microtubule-disrupting ability.
T5886	Benzenebutyric acid	Benzenebutyric acid is an inhibitor of HDAC,and is an antineoplastic agent.
T7385	WT-161	WT161 is a potent and selective inhibitor of HDAC6 (IC50:0.40 nM).
T7691	NSC 3852	NSC 3852 is a potent inhibitor of histone deacetylase.
T7664	Pyroxamide	Pyroxamide is an histone deacetylases (HDACs) inhibitor with antineoplastic properties ( HDAC1;IC50: 0.1-0.2 μM).
TQ0074	ACY-775	ACY-775 is an effective and specific inhibitor of HDAC6 (IC50: 7.5 nM).
T8508	HDAC-IN-3	HDAC-IN-3 is a potent histone deacetylase (HDAC) inhibitor, and treatment chronic inflammatory disorders.
T10244	ACY-1083	ACY-1083 is a selective and brain-penetrating HDAC6 inhibitor (IC50: 3 nM). It is 260-fold more selective for HDAC6 than all other classes of HDAC isoforms. ACY...
T10245	ACY-957	ACY-957 is an orally active and selective inhibitor of HDAC1 and HDAC2 (IC50s: 7 nM, 18 nM, and 1300 nM against HDAC1/2/3) and shows no inhibition on HDAC4/5/6/...
T13996	1-Naphthohydroxamic acid	1-Naphthohydroxamic acid is a potent and selective HDAC8 inhibitor with an IC50 of 14 μM, and it is more selectively for HDAC8 than class I HDAC1 and class II ...
T14305	Apicidin	Apicidin (OSI 2040) is a fungal metabolite, acts as a histone deacetylase (HDAC) inhibitor. It has antiparasitic activity and a broad spectrum antiproliferative...
T10255	AES-135	AES-135 is a potent HDAC inhibitor, inhibits HDAC3, HDAC6, HDAC11 (IC50s: 654, 190, and 636 nM) with anti-tumor activity.
T10602L	BRD 4354	BRD 4354 is an inhibitor of HDAC5 and HDAC9 (IC50s: 0.85 and 1.88 μM for HDAC5 and HDAC9).
T14936	CG-200745	CG-200745 is a potent inhibitor of HDAC. CG200745 induces apoptosis and also inhibits the deacetylation of histone H3 and tubulin.
T14947	CHDI-390576	CHDI-390576 is a CNS penetrant class IIa HDAC inhibitor (IC50s: 54 nM, 60 nM, 31 nM, 50 nM for class IIa HDAC4, HDAC5, HDAC7, HDAC9). It shows >500-fold selecti...
T11329	FT895	FT895 is a selective and potent selective HDAC11 inhibitor with an IC50 of 3 nM.
T10602	BRD 4354 ditrifluoroacetate	BRD 4354 (ditrifluoroacetate) is a moderately potent inhibitor of HDAC5 and HDAC9 (IC50s: 0.85 and 1.88 μM).
T10603	BRD-6929	BRD-6929 is a selective, brain-penetrant HDAC1 and HDAC2 inhibitor (IC50: 1 and 8 nM).
T11542	HDAC-IN-4	HDAC-IN-4,Antitumoral activity. is a selective HDAC6 and HDAC10 inhibitor with pIC50s of 7.2 and 6.8 in BRET assay, respectively.
T11543	HDAC-IN-5	HDAC-IN-5 is a histone deacetylase (HDAC) inhibitor.
T11544	HDACs/mTOR Inhibitor 1	HDACs/mTOR Inhibitor 1 stimulates cell cycle arrest in G0/G1 phase and induce tumor cell apoptosis with low toxicity in vivo. HDACs/mTOR Inhibitor 1 is a dual ...
T10777	CG347B	CG347B is a selective inhibitor of HDAC6.
T8517	PXD-101	Belinostat is an inhibitor of hydroxamic acid-type histone deacetylase (HDAC, IC50 of 27 nM in HeLa cell extracts),and with antineoplastic activity.
T10883	CRA-026440	CRA-026440 is a potent, broad-spectrum HDAC inhibitor (Kis: 4, 14, 11, 15, 7, and 20 nM for HDAC1, HDAC2, HDAC3, HDAC6, HDAC8, and HDAC10).
T11706	JAK1-IN-7	JAK1-IN-7 is a Janus-associated kinase 1 (JAK1) inhibitor, has an anti-inflammatory effect.
T16153	MS4078	MS4078 is an anaplastic lymphoma kinase (ALK) PROTAC. It has a Kd of 19 nM for binding affinity to ALK.
T16288	Neuropathiazol	Neuropathiazol is a synthetic small molecule. It also causes neuronal differentiation of adult hippocampal neural progenitor cells.
T16415	Oxamflatin	Oxamflatin is an effective inhibitor of HDAC (IC50: 15.7 nM).
T16729	Remetinostat	Remetinostat is a hydroxamic acid-based inhibitor of histone deacetylase enzymes. It is under development for the treatment of cutaneous T-cell lymphoma.
T16805	RTS-V5	RTS-V5 is a dual inhibitor of HDAC/proteasome (IC50s: 6.9, 18, 15, 0.27, 0.53 μM for HDAC1, HDAC2, HDAC3, HDAC6, HDAC8, respectively).
T16936	SS-208	SS-208 is a selective HDAC6 inhibitor (IC50: 12 nM). SS-208 has anti-tumor activity in melanoma.
T16962	SW-100	SW-100 is a selective histone deacetylase 6 inhibitor (IC50: 2.3 nM). It also shows at least 1000-fold selectivity for HDAC6 relative to all other HDAC isozymes...
T17028	Tefinostat	Tefinostat is a monocyte/macrophage-targeted pan HDAC inhibitor. That is cleaved into active acid CHR-2847 by the intracellular esterase human carboxylesterase-...
T2S0606	Bakkenolide A	Bakkenolide A has antifeedant and growth inhibitory effects on neonate variegated cutworms, it inhibits leukemia by regulation of HDAC3 and PI3K/Akt-related sig...
TN4288	Isoferulic acid	Isoferulic acid is an effective natural antioxidant in both lipid and aqueous media, it may be a new promising anti-glycation agent for the prevention of diabet...