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HDAC-IN-40

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Catalog No. T60082Cas No. 2463198-51-6

HDAC-IN-40 is a potent alkoxyamide-based HDAC inhibitor with a Ki of 60 nM for HDAC2 and 30 nM for HDAC6, exhibiting antitumor effects.

HDAC-IN-40

HDAC-IN-40

🥰Excellent
Purity: 99.01%
Catalog No. T60082Cas No. 2463198-51-6
HDAC-IN-40 is a potent alkoxyamide-based HDAC inhibitor with a Ki of 60 nM for HDAC2 and 30 nM for HDAC6, exhibiting antitumor effects.
Pack SizePriceAvailabilityQuantity
1 mg$31In Stock
5 mg$73In Stock
10 mg$118In Stock
25 mg$273In Stock
50 mg$403In Stock
100 mg$573In Stock
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Purity:99.01%
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Product Introduction

Bioactivity
Description
HDAC-IN-40 is a potent alkoxyamide-based HDAC inhibitor with a Ki of 60 nM for HDAC2 and 30 nM for HDAC6, exhibiting antitumor effects.
In vitro
HDAC-IN-40 shows antiproliferative activity against the cell line A2780 and Cal27 with IC50 values of 0.89 µM and 0.72 µM, respectively. HDAC-IN-40 induces accumulation of acetyl α-tubulin in Cal27 and Cal27CisR. HDAC-IN-40 enhances the Cisplatin-induced cytotoxicity via caspase-3/7 activation[1].
Chemical Properties
Molecular Weight326.35
FormulaC15H22N2O6
Cas No.2463198-51-6
SmilesCOc1cc(OC)cc(c1)C(=O)NOCCCCCC(=O)NO
Relative Density.1.208 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 200 mg/mL (612.9 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.0642 mL15.3210 mL30.6419 mL153.2097 mL
5 mM0.6128 mL3.0642 mL6.1284 mL30.6419 mL
10 mM0.3064 mL1.5321 mL3.0642 mL15.3210 mL
20 mM0.1532 mL0.7660 mL1.5321 mL7.6605 mL
50 mM0.0613 mL0.3064 mL0.6128 mL3.0642 mL
100 mM0.0306 mL0.1532 mL0.3064 mL1.5321 mL

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