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HDAC-IN-40 is a potent alkoxyamide-based HDAC inhibitor with a Ki of 60 nM for HDAC2 and 30 nM for HDAC6, exhibiting antitumor effects.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $31 | In Stock | |
5 mg | $73 | In Stock | |
10 mg | $118 | In Stock | |
25 mg | $273 | In Stock | |
50 mg | $403 | In Stock | |
100 mg | $573 | In Stock |
Description | HDAC-IN-40 is a potent alkoxyamide-based HDAC inhibitor with a Ki of 60 nM for HDAC2 and 30 nM for HDAC6, exhibiting antitumor effects. |
In vitro | HDAC-IN-40 shows antiproliferative activity against the cell line A2780 and Cal27 with IC50 values of 0.89 µM and 0.72 µM, respectively. HDAC-IN-40 induces accumulation of acetyl α-tubulin in Cal27 and Cal27CisR. HDAC-IN-40 enhances the Cisplatin-induced cytotoxicity via caspase-3/7 activation[1]. |
Molecular Weight | 326.35 |
Formula | C15H22N2O6 |
Cas No. | 2463198-51-6 |
Smiles | COc1cc(OC)cc(c1)C(=O)NOCCCCCC(=O)NO |
Relative Density. | 1.208 g/cm3 (Predicted) |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 200 mg/mL (612.9 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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