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Pack Size | Price | Availability | Quantity |
---|---|---|---|
100 mg | $29 | In Stock | |
1 mL x 10 mM (in DMSO) | $29 | In Stock |
Description | Suberoyl bis-hydroxamic acid (SBHA) is a Histone deacetylase (HDAC) inhibitor. HDAC is required for transcriptional modulation, cell cycle regulation and development. It is an enzyme that deacetylates lysine residues on the N-terminal of the core histones. |
Targets&IC50 | HDAC3:0.3 μm (JK cell), HDAC1:0.25 μm (JK cell) |
In vitro | In MEL cells, SBHA leads to the accumulation of acetylated H4, indicating the hydroxamic acid groups are involved in increasing potency and inhibition of HDAC activity. In Jurkat cells, SHBA inhibits the HDAC1 and HDAC3 activities with IC50 value of 0.25 and 0.3 μm respectively. |
Alias | SBHA, Suberohydroxamic acid |
Molecular Weight | 204.22 |
Formula | C8H16N2O4 |
Cas No. | 38937-66-5 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||||||||||||
Solubility Information | H2O: 8.16 mg/mL (40 mM), Sonication is recommended. DMSO: 49 mg/mL (239.93 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
H2O/DMSO
DMSO
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