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Divalproex Sodium
🥰Excellent
Catalog No. T6474Cas No. 76584-70-8
Alias Valproate semisodium, Epival
Divalproex Sodium (Valproate semisodium) binds to and inhibits gamma-aminobutyric acid (GABA) transaminase and its anticonvulsant activity may be exerted by increasing brain concentration of GABA and by inhibiting enzymes that catabolize GABA or block the reuptake of GABA into glia and nerve endings. It also is an HDAC inhibitor， Comprised of sodium valproate and valproic acid with anticonvulsant and antiepileptic activities. Divalproex may also work by suppressing repetitive neuronal firing through the inhibition of voltage-sensitive sodium channels.
Divalproex Sodium
🥰Excellent
Purity: 99.84%
Catalog No. T6474Alias Valproate semisodium, EpivalCas No. 76584-70-8
Divalproex Sodium (Valproate semisodium) binds to and inhibits gamma-aminobutyric acid (GABA) transaminase and its anticonvulsant activity may be exerted by increasing brain concentration of GABA and by inhibiting enzymes that catabolize GABA or block the reuptake of GABA into glia and nerve endings. It also is an HDAC inhibitor， Comprised of sodium valproate and valproic acid with anticonvulsant and antiepileptic activities. Divalproex may also work by suppressing repetitive neuronal firing through the inhibition of voltage-sensitive sodium channels.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 10 mg | $33 | In Stock | |
| 25 mg | $50 | In Stock | |
| 50 mg | $72 | In Stock | |
| 100 mg | $118 | In Stock | |
| 200 mg | $198 | In Stock | |
| 500 mg | $353 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $50 | In Stock |
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Purity:99.84%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Divalproex Sodium (Valproate semisodium) binds to and inhibits gamma-aminobutyric acid (GABA) transaminase and its anticonvulsant activity may be exerted by increasing brain concentration of GABA and by inhibiting enzymes that catabolize GABA or block the reuptake of GABA into glia and nerve endings. It also is an HDAC inhibitor， Comprised of sodium valproate and valproic acid with anticonvulsant and antiepileptic activities. Divalproex may also work by suppressing repetitive neuronal firing through the inhibition of voltage-sensitive sodium channels. |
| In vitro | Divalproex sodium enhances apoptosis, IM-induced cell growth inhibition and cell cycle arrest in K562-G and K562-S cells. It enhances the inhibitory effects of IM on SIRT1 expression in K562-G and K562-S cells. Divalproex sodium enhances the effect of IM on apoptosis in K562-G cells partly through SIRT1. |
| In vivo | Divalproex (500 mg/kg) significantly increases dopamine (DA) and acetylcholine (ACh) efflux in the rat hippocampus, and DA, but not ACh, efflux in the rat medial prefrontal cortex (mPFC), whereas 50 mg/kg has no effect on DA or ACh in either region. Divalproex (50 mg/kg) combined with the atypical APDs Olanzapine (1.0 mg/kg) or Aripiprazole (0.3 mg/kg) significantly potentiates the effect of both antipsychotic drugs (APDs) on DA, but not ACh efflux in the HIP and mPFC. |
| Alias | Valproate semisodium, Epival |
| Molecular Weight | 310.41 |
| Formula | C8H16O2·C8H15O2·Na |
| Cas No. | 76584-70-8 |
| Smiles | [Na+].CCCC(CCC)C(O)=O.CCCC(CCC)C([O-])=O |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | H2O: 57 mg/mL (183.6 mM) DMSO: 75 mg/mL (241.62 mM), Sonication is recommended.  Ethanol: 58 mg/mL (186.8 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
H2O/Ethanol/DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Keywords
VPA (sodium)(2:1)Valproic acid (sodium)(2:1)small cell lung cancerSCLCproteasomalNotch1NotchMitophagyMitochondrial AutophagymigraineInhibitorinhibitHuman immunodeficiency virusHIVHistone deacetylaseshepatic fat accumulationheadachesHDACGABAReceptorGABA ReceptorepilepsyEndogenous MetaboliteDivalproex Sodiumdegradationbipolar disorderAutophagyApoptosisanticonvulsantanticancer2-Propylpentanoic Acid (sodium)(2:1)
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