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SS-208

🥰Excellent
Catalog No. T16936Cas No. 2245942-72-5

SS-208 is a selective inhibitor of HDAC6 (IC50 = 12 nM) with anti-tumor activity. SS-208 shows selectivity over other HDAC subtypes.

SS-208

SS-208

🥰Excellent
Purity: 99.07%
Catalog No. T16936Cas No. 2245942-72-5
SS-208 is a selective inhibitor of HDAC6 (IC50 = 12 nM) with anti-tumor activity. SS-208 shows selectivity over other HDAC subtypes.
Pack SizePriceAvailabilityQuantity
1 mg$53In Stock
5 mg$118In Stock
10 mg$188In Stock
25 mg$328In Stock
50 mg$472In Stock
100 mg$648In Stock
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Purity:99.07%
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Product Introduction

Bioactivity
Description
SS-208 is a selective inhibitor of HDAC6 (IC50 = 12 nM) with anti-tumor activity. SS-208 shows selectivity over other HDAC subtypes.
Targets&IC50
HDAC7:8.34 μM, HDAC11:5.12 μM, HDAC5:6.91 μM, HDAC8:1.23 μM, HDAC1:1.39 μM, HDAC6:12 nM
In vivo
In C57BL/6 mice injected immunogenic murine SM1 melanoma cells, SS-208 (25 mg/kg; i.p.) causes a significant reduction of the tumor growth[1].
Chemical Properties
Molecular Weight344.15
FormulaC13H11Cl2N3O4
Cas No.2245942-72-5
SmilesONC(=O)c1cc(CCNC(=O)c2ccc(Cl)c(Cl)c2)on1
Relative Density.1.507 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 100 mg/mL (290.6 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.9057 mL14.5285 mL29.0571 mL145.2855 mL
5 mM0.5811 mL2.9057 mL5.8114 mL29.0571 mL
10 mM0.2906 mL1.4529 mL2.9057 mL14.5285 mL
20 mM0.1453 mL0.7264 mL1.4529 mL7.2643 mL
50 mM0.0581 mL0.2906 mL0.5811 mL2.9057 mL
100 mM0.0291 mL0.1453 mL0.2906 mL1.4529 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

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