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SS-208 is a selective inhibitor of HDAC6 (IC50 = 12 nM) with anti-tumor activity. SS-208 shows selectivity over other HDAC subtypes.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $53 | In Stock | |
5 mg | $118 | In Stock | |
10 mg | $188 | In Stock | |
25 mg | $328 | In Stock | |
50 mg | $472 | In Stock | |
100 mg | $648 | In Stock |
Description | SS-208 is a selective inhibitor of HDAC6 (IC50 = 12 nM) with anti-tumor activity. SS-208 shows selectivity over other HDAC subtypes. |
Targets&IC50 | HDAC7:8.34 μM, HDAC11:5.12 μM, HDAC5:6.91 μM, HDAC8:1.23 μM, HDAC1:1.39 μM, HDAC6:12 nM |
In vivo | In C57BL/6 mice injected immunogenic murine SM1 melanoma cells, SS-208 (25 mg/kg; i.p.) causes a significant reduction of the tumor growth[1]. |
Molecular Weight | 344.15 |
Formula | C13H11Cl2N3O4 |
Cas No. | 2245942-72-5 |
Smiles | ONC(=O)c1cc(CCNC(=O)c2ccc(Cl)c(Cl)c2)on1 |
Relative Density. | 1.507 g/cm3 (Predicted) |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 100 mg/mL (290.6 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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