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SW-100

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Purity:98%

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COA HNMR

SW-100

Catalog No. T16962Cas No. 2126744-35-0

SW-100 is a selective histone deacetylase 6 inhibitor (IC50: 2.3 nM). It also shows at least 1000-fold selectivity for HDAC6 relative to all other HDAC isozymes. SW-100 displays an obviously improved ability to cross the blood-brain-barrier.

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Pack Size	Price	Availability
1 mg	$51	In Stock
2 mg	$74	In Stock
5 mg	$122	In Stock
10 mg	$197	In Stock
25 mg	$328	In Stock
50 mg	$489	In Stock
100 mg	$713	In Stock
1 mL x 10 mM (in DMSO)	$133	In Stock

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Product Introduction

Bioactivity

Description	SW-100 is a selective histone deacetylase 6 inhibitor (IC50: 2.3 nM). It also shows at least 1000-fold selectivity for HDAC6 relative to all other HDAC isozymes. SW-100 displays an obviously improved ability to cross the blood-brain-barrier.
In vitro	SW-100 (0.01-10 μM; 48 hours) shows obvious enhance in the acetylated α-tubulin levels in a dose-dependent manner [1].
In vivo	In mouse model of Fragile X syndrome, SW-100 (20 mg/kg; i.p.; twice a day for two days) ameliorates several memory and learning impairments including novel object recognition, temporal ordering, and coordinate and categorical spatial processing [1].

Chemical Properties

Molecular Weight	316.78
Formula	C17H17ClN2O2
Cas No.	2126744-35-0

Storage & Solubility Information

Storage

store at low temperature Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 125 mg/mL (394.60 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.1568 mL	15.7838 mL	31.5676 mL	157.8382 mL
5 mM	0.6314 mL	3.1568 mL	6.3135 mL	31.5676 mL
10 mM	0.3157 mL	1.5784 mL	3.1568 mL	15.7838 mL
20 mM	0.1578 mL	0.7892 mL	1.5784 mL	7.8919 mL
50 mM	0.0631 mL	0.3157 mL	0.6314 mL	3.1568 mL
100 mM	0.0316 mL	0.1578 mL	0.3157 mL	1.5784 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc