Shopping Cart
- Remove All
- Your shopping cart is currently empty
SAHA-OH, a selective HDAC6 inhibitor with an IC50 of 23 nM, exhibits a 10- to 47-fold greater selectivity for HDAC6 over HDACs 1, 2, 3, and 8. It demonstrates anti-inflammatory effects and reduces macrophage apoptosis [1].
Pack Size | Price | Availability | Quantity |
---|---|---|---|
25 mg | $1,520 | 6-8 weeks | |
50 mg | $1,980 | 6-8 weeks | |
100 mg | $2,500 | 6-8 weeks |
Description | SAHA-OH, a selective HDAC6 inhibitor with an IC50 of 23 nM, exhibits a 10- to 47-fold greater selectivity for HDAC6 over HDACs 1, 2, 3, and 8. It demonstrates anti-inflammatory effects and reduces macrophage apoptosis [1]. |
Targets&IC50 | HDAC3:359 nM, HDAC1:237 nM, HDAC6:23 nM, HDAC8:1070 nM, HDAC2:399 nM |
In vitro | SAHA-OH, at concentrations ranging from 0.67 to 10.76 μM over a period of 51 hours, demonstrates inhibitory effects on bone marrow macrophages [1]. When applied to bone marrow-derived macrophages (BMMØs) at 0.01 μM for 3 hours, SAHA-OH significantly reduces the secretion of cytokines such as IL-6, TNFα, IFNβ, IL-1β, IL-10, MCP-1 (CCL2), and GROα (CXCL1) [1]. Additionally, a 10 μM SAHA-OH treatment for either 4 or 9 hours results in increased acetylation of cytoplasmic α-tubulin and nuclear histone H3 [1]. At dosages up to 30 μM, a 3-hour treatment with SAHA-OH effectively decreases apoptosis in macrophages and reduces death in B cells [1]. |
In vivo | SAHA-OH, administered through intraperitoneal injection at a dose of 50 mg/kg in a single dose, mitigates splenic damage and diminishes the levels of proinflammatory cytokines in plasma in a mouse model of LPS-induced endotoxemia [1]. |
Molecular Weight | 294.35 |
Formula | C15H22N2O4 |
Cas No. | 2857098-30-5 |
Storage | Shipping with blue ice. |
Copyright © 2015-2024 TargetMol Chemicals Inc. All Rights Reserved.