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BRD3308

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Purity:97.12%

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COA HPLC HNMR

BRD3308

Catalog No. T8233Cas No. 1550053-02-5

BRD3308 is a highly selective inhibitor of HDAC3(IC50 of 54 nM), attenuating PE-mediated phosphorylation of ERK but not JNK.

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Pack Size	Price	Availability
1 mg	$38	In Stock
2 mg	$54	In Stock
5 mg	$87	In Stock
10 mg	$128	In Stock
25 mg	$233	In Stock
50 mg	$352	In Stock
100 mg	$528	In Stock
1 mL x 10 mM (in DMSO)	$97	In Stock

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Product Introduction

Bioactivity

Description	BRD3308 is a highly selective inhibitor of HDAC3(IC50 of 54 nM), attenuating PE-mediated phosphorylation of ERK but not JNK.
In vivo	BRD3308 is a selective HDAC3 inhibitor,to reduce hyperglycaemia and increase insulin secretion in a rat model of type 2 diabetes.?At diabetes onset, an ambulatory hyperglycaemic clamp was performed.?HDAC3 inhibition improved hyperglycaemia over the study period without affecting weight gain.?At the end of the hyperglycaemic clamp, circulating insulin levels were significantly higher in BRD3308-treated rats.?Pancreatic insulin staining and contents were also significantly higher.?These findings highlight HDAC3 as a key therapeutic target for β-cell protection in type 2 diabetes[1].
Animal Research	Male Zucker Diabetic Fatty (Obese) rats (6-week-old); 5 mg/kg; Intraperitoneal injection; every second day

Chemical Properties

Molecular Weight	287.29
Formula	C15H14FN3O2
Cas No.	1550053-02-5

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 52 mg/ml(181 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.4808 mL	17.4040 mL	34.8080 mL	174.0402 mL
5 mM	0.6962 mL	3.4808 mL	6.9616 mL	34.8080 mL
10 mM	0.3481 mL	1.7404 mL	3.4808 mL	17.4040 mL
20 mM	0.1740 mL	0.8702 mL	1.7404 mL	8.7020 mL
50 mM	0.0696 mL	0.3481 mL	0.6962 mL	3.4808 mL
100 mM	0.0348 mL	0.1740 mL	0.3481 mL	1.7404 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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BRD3308