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NT160 is a fluorinated radioactive compound, a potent class IIa histone deacetylase (HDAC) inhibitor, used in the study of neurological diseases.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $100 | In Stock | |
5 mg | $247 | In Stock | |
10 mg | $396 | In Stock | |
25 mg | $795 | In Stock | |
50 mg | $1,280 | In Stock | |
100 mg | $1,980 | In Stock | |
1 mL x 10 mM (in DMSO) | $272 | In Stock |
Description | NT160 is a fluorinated radioactive compound, a potent class IIa histone deacetylase (HDAC) inhibitor, used in the study of neurological diseases. |
Targets&IC50 | HDAC4:0.08 nM, HDAC7:1.0 nM, HDAC9:0.9 nM, HDAC5:1.2 nM |
In vitro | NT160 is a highly effective Class IIa HDAC inhibitor with an IC50 value of 0.046 μM. NT160 showed very high inhibition on HDAC4, HDAC5, HDAC7 and HDAC9, with IC50 values of 0.08 nM, 1.2 nM, 1.0 nM and 0.9 nM, respectively. [1] |
In vivo | NT160 was able to penetrate the blood-brain barrier and accumulate in the brains of mice. [1] |
Alias | NT 160 |
Molecular Weight | 418.41 |
Formula | C21H21F3N4O2 |
Cas No. | 1418293-40-9 |
Smiles | C(F)(F)(F)C1=NC(=NO1)C2=CC=C(C(N[C@@H](CN(CC3=CC=CC=C3)C)C)=O)C=C2 |
Storage | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 80 mg/mL (191.2 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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