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BRD73954

🥰Excellent
Catalog No. T6421Cas No. 1440209-96-0

BRD73954, an effective and specific HDAC inhibitor, which is with IC50 of 36 nM and 120 nM for HDAC6 and HDAC8, respectively.

BRD73954

BRD73954

🥰Excellent
Purity: 99.65%
Catalog No. T6421Cas No. 1440209-96-0
BRD73954, an effective and specific HDAC inhibitor, which is with IC50 of 36 nM and 120 nM for HDAC6 and HDAC8, respectively.
Pack SizePriceAvailabilityQuantity
2 mg$30In Stock
5 mg$54In Stock
10 mg$91In Stock
25 mg$182In Stock
50 mg$275In Stock
100 mg$403In Stock
200 mg$573In Stock
1 mL x 10 mM (in DMSO)$54In Stock
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Purity:99.65%
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Product Introduction

Bioactivity
Description
BRD73954, an effective and specific HDAC inhibitor, which is with IC50 of 36 nM and 120 nM for HDAC6 and HDAC8, respectively.
Targets&IC50
HDAC6:36 nM, HDAC8:120 nM
In vitro
As compared to the other class I and II histone deacetylases (HDACs) (HDAC1, 12 μM; HDAC2, 9 μM; HDAC3, 23 μM; HDAC4, >33 μM; HDAC5, >33 μM; HDAC7, 13 μM; HDAC8, 120 nM; HDAC9, >33 μM), BRD73954 maintains excellent selectivity toward HDAC6 and HDAC8 with IC50 of 36 nM and 120 nM, respectively. Treatment with BRD73954 results in a robust increase in α -tubulin acetylation. [1]
Chemical Properties
Molecular Weight284.31
FormulaC16H16N2O3
Cas No.1440209-96-0
SmilesC(NCCC1=CC=CC=C1)(=O)C2=CC(C(NO)=O)=CC=C2
Relative Density.1.245 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
Ethanol: 5.7 mg/mL (20 mM)), Heating is recommended.
DMSO: 16.67 mg/mL (58.62 mM)
Solution Preparation Table
Ethanol/DMSO
1mg5mg10mg50mg
1 mM3.5173 mL17.5864 mL35.1729 mL175.8644 mL
5 mM0.7035 mL3.5173 mL7.0346 mL35.1729 mL
10 mM0.3517 mL1.7586 mL3.5173 mL17.5864 mL
20 mM0.1759 mL0.8793 mL1.7586 mL8.7932 mL
DMSO
1mg5mg10mg50mg
50 mM0.0703 mL0.3517 mL0.7035 mL3.5173 mL

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