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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $41 | In Stock | |
2 mg | $50 | In Stock | |
5 mg | $90 | In Stock | |
10 mg | $151 | In Stock | |
25 mg | $303 | In Stock | |
50 mg | $458 | In Stock | |
100 mg | $673 | In Stock | |
500 mg | $1,430 | In Stock | |
1 mL x 10 mM (in DMSO) | $90 | In Stock |
Description | BRD73954, an effective and specific HDAC inhibitor, which is with IC50 of 36 nM and 120 nM for HDAC6 and HDAC8, respectively. |
In vitro | As compared to the other class I and II histone deacetylases (HDACs) (HDAC1, 12 μM; HDAC2, 9 μM; HDAC3, 23 μM; HDAC4, >33 μM; HDAC5, >33 μM; HDAC7, 13 μM; HDAC8, 120 nM; HDAC9, >33 μM), BRD73954 maintains excellent selectivity toward HDAC6 and HDAC8 with IC50 of 36 nM and 120 nM, respectively. Treatment with BRD73954 results in a robust increase in α -tubulin acetylation. [1] |
Molecular Weight | 284.31 |
Formula | C16H16N2O3 |
Cas No. | 1440209-96-0 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | ||||||||||||||||||||||||||||||||||||||||
Solubility Information | Ethanol: 5.7 mg/mL (20 mM)) DMSO: 16.67 mg/mL (58.62 mM) | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
DMSO/Ethanol
DMSO
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