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CHDI-390576

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COA HNMR

CHDI-390576

Catalog No. T14947Cas No. 1629729-98-1

CHDI-390576 is a CNS-permeable, selective and potent dibenzoyl isohydroxamic acid class IIa histone deacetylase (HDAC) inhibitor that inhibits class IIa HDAC 4, HDAC 5, HDAC 7, HDAC 9, and can be used in cancer research.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Pack Size	Price	Availability
1 mg	$42	In Stock
5 mg	$98	In Stock
10 mg	$163	In Stock
25 mg	$317	In Stock
50 mg	$468	In Stock
100 mg	$689	In Stock

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Product Introduction

Bioactivity

Description	CHDI-390576 is a CNS-permeable, selective and potent dibenzoyl isohydroxamic acid class IIa histone deacetylase (HDAC) inhibitor that inhibits class IIa HDAC 4, HDAC 5, HDAC 7, HDAC 9, and can be used in cancer research.
Targets&IC50	HDAC5:60 nM, HDAC3:25.8 μM, HDAC7:31 nM, HDAC1:39.7 μM, HDAC4:54 nM, HDAC8:9.1 μM, HDAC9 (human):50 nM, HDAC6 (human):6.2 μM
In vitro	CHDI-390576 exhibits good affinity to the catalytic domain of HDAC4, and it inhibits class I HDACs (1, 3, 8) and class IIb HDAC6[1].

Chemical Properties

Molecular Weight	391.32
Formula	C19H13F4N3O2
Cas No.	1629729-98-1

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 200 mg/mL (511.09 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5555 mL	12.7773 mL	25.5545 mL	127.7727 mL
5 mM	0.5111 mL	2.5555 mL	5.1109 mL	25.5545 mL
10 mM	0.2555 mL	1.2777 mL	2.5555 mL	12.7773 mL
20 mM	0.1278 mL	0.6389 mL	1.2777 mL	6.3886 mL
50 mM	0.0511 mL	0.2555 mL	0.5111 mL	2.5555 mL
100 mM	0.0256 mL	0.1278 mL	0.2555 mL	1.2777 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

You can also refer to dose conversion for different animals. More

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc