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SIS17

🥰Excellent
Catalog No. T5631Cas No. 2374313-54-7

SIS17 is a potent and selective HDAC 11 inhibitor with an IC50 value of 0.83 μM. SIS17, is active in cells and inhibited the demyristoylation of a known HDAC11 substrate, serine hydroxymethyl transferase 2, without inhibiting other HDACs.

SIS17

SIS17

🥰Excellent
Purity: 98.22%
Catalog No. T5631Cas No. 2374313-54-7
SIS17 is a potent and selective HDAC 11 inhibitor with an IC50 value of 0.83 μM. SIS17, is active in cells and inhibited the demyristoylation of a known HDAC11 substrate, serine hydroxymethyl transferase 2, without inhibiting other HDACs.
Pack SizePriceAvailabilityQuantity
5 mg$59In Stock
10 mg$98In Stock
25 mg$189In Stock
50 mg$322In Stock
100 mg$513In Stock
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Purity:98.22%
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Product Introduction

Bioactivity
Description
SIS17 is a potent and selective HDAC 11 inhibitor with an IC50 value of 0.83 μM. SIS17, is active in cells and inhibited the demyristoylation of a known HDAC11 substrate, serine hydroxymethyl transferase 2, without inhibiting other HDACs.
Targets&IC50
HDAC11:0.83 μM (IC50)
In vitro
SIS17, is active in cells and inhibited the demyristoylation of a known HDAC11 substrate, serine hydroxymethyl transferase 2, without inhibiting other HDACs.
Chemical Properties
Molecular Weight366.6
FormulaC21H38N2OS
Cas No.2374313-54-7
SmilesCCCCCCCCCCCCCCCCNNC(=O)c1cccs1
Relative Density.0.975 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 125 mg/mL (340.97 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.7278 mL13.6388 mL27.2777 mL136.3884 mL
5 mM0.5456 mL2.7278 mL5.4555 mL27.2777 mL
10 mM0.2728 mL1.3639 mL2.7278 mL13.6388 mL
20 mM0.1364 mL0.6819 mL1.3639 mL6.8194 mL
50 mM0.0546 mL0.2728 mL0.5456 mL2.7278 mL
100 mM0.0273 mL0.1364 mL0.2728 mL1.3639 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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