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ACY-1083
Catalog No. T10244Cas No. 1708113-43-2
ACY-1083 is a selective, brain-penetrating HDAC6 inhibitor (IC50: 3 nM) that effectively reverses chemotherapy-induced peripheral neuropathy.
ACY-1083
Catalog No. T10244Cas No. 1708113-43-2
ACY-1083 is a selective, brain-penetrating HDAC6 inhibitor (IC50: 3 nM) that effectively reverses chemotherapy-induced peripheral neuropathy.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $155 | In Stock | |
| 5 mg | $328 | In Stock | |
| 10 mg | $559 | In Stock | |
| 25 mg | $883 | In Stock | |
| 50 mg | $1,230 | In Stock | |
| 100 mg | $1,660 | In Stock | |
| 500 mg | $3,330 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $363 | In Stock |
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Purity:99.22%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | ACY-1083 is a selective, brain-penetrating HDAC6 inhibitor (IC50: 3 nM) that effectively reverses chemotherapy-induced peripheral neuropathy. |
| Targets&IC50 | HDAC6:3 nM |
| In vitro | ACY-1083 (30 and 300 nM) dose-dependently improves cell viability[2]. |
| In vivo | In C57BL/6J mice, ACY-1083 (10 mg/kg; i.p.) effectively relieves Cisplatin-induced mechanical allodynia. In adult male SD rats, ACY-1083 (3 mg/kg; orally) reverses Paclitaxel-induced mechanical allodynia. ACY-1083(5 mg/kg; i.p.) shows a Cmax of 936 ng/mL, a half-life (T1/2) of 3.5h, and a biologically active plasma exposure of 8 hours[1]. |
| Molecular Weight | 348.35 |
| Formula | C17H18F2N4O2 |
| Cas No. | 1708113-43-2 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 180 mg/mL (516.7 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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