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Crebinostat
🥰Excellent
Catalog No. T27083Cas No. 1092061-61-4
Crebinostat is a potent histone deacetylase (HDAC) inhibitor, targeting HDAC1, HDAC2, HDAC3, and HDAC6 with IC50s of 0.7 nM, 1.0 nM, 2.0 nM, and 9.3 nM, respectively. It increases the density of synapsin-1 punctae along dendrites in neurons in vitro, modulates chromatin-mediated neuroplasticity, and enhances memory in mice. Additionally, Crebinostat induces histone H3 and H4 acetylation and enhances the expression of Egr1, a cAMP-responsive element binding protein (CREB) target gene.
Crebinostat
🥰Excellent
Purity: 95%
Catalog No. T27083Cas No. 1092061-61-4
Crebinostat is a potent histone deacetylase (HDAC) inhibitor, targeting HDAC1, HDAC2, HDAC3, and HDAC6 with IC50s of 0.7 nM, 1.0 nM, 2.0 nM, and 9.3 nM, respectively. It increases the density of synapsin-1 punctae along dendrites in neurons in vitro, modulates chromatin-mediated neuroplasticity, and enhances memory in mice. Additionally, Crebinostat induces histone H3 and H4 acetylation and enhances the expression of Egr1, a cAMP-responsive element binding protein (CREB) target gene.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | 332 € | In Stock | |
| 5 mg | 786 € | In Stock | |
| 10 mg | 1.073 € | In Stock | |
| 25 mg | 1.510 € | In Stock | |
| 50 mg | 1.881 € | In Stock | |
| 100 mg | 2.375 € | In Stock | |
| 500 mg | 4.655 € | In Stock |
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Purity:95%
ee:100%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Crebinostat is a potent histone deacetylase (HDAC) inhibitor, targeting HDAC1, HDAC2, HDAC3, and HDAC6 with IC50s of 0.7 nM, 1.0 nM, 2.0 nM, and 9.3 nM, respectively. It increases the density of synapsin-1 punctae along dendrites in neurons in vitro, modulates chromatin-mediated neuroplasticity, and enhances memory in mice. Additionally, Crebinostat induces histone H3 and H4 acetylation and enhances the expression of Egr1, a cAMP-responsive element binding protein (CREB) target gene. |
| Targets&IC50 | HDAC1:0.7 nM, HDAC6:9.3 nM, HDAC2:1.0 nM, HDAC3:2.0 nM |
| In vitro | Crebinostat (1 μM; 24 h) induces acetylation of AcH4K12 and AcH3K9 in mouse primary neuronal cells, with EC50 values of 0.29 μM and 0.18 μM, respectively. It downregulates Mapt mRNA expression and upregulates Hspa1b (Hsp70) and Bdnf mRNA expression, while increasing histone acetylation and synapsin I punctae along dendrites in primary cultured neurons.[1] |
| In vivo | Crebinostat (25 mg/kg; i.p.; for 10 days; Male C57BL/6J mice) boosts memory in mice during contextual fear conditioning and leads to a rise in overall hippocampal acetylation of H4K12 and H3K9.[1] |
| Molecular Weight | 353.41 |
| Formula | C20H23N3O3 |
| Cas No. | 1092061-61-4 |
| Smiles | C(=NNC(CCCCCC(NO)=O)=O)C1=CC=C(C=C1)C2=CC=CC=C2 |
| Relative Density. | 1.16 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | DMSO: 1 mg/mL, Sonication is recommended.  |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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