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Tefinostat

🥰Excellent
Catalog No. T17028Cas No. 914382-60-8
Alias CHR-2845

Tefinostat (CHR-2845) is a potent monocyte/macrophage-targeted histone deacetylase (HDAC) inhibitor that is cleaved to the active acid CHR-2847 by intracellular esterase human carboxylesterase-1 (hCE-1). Tefinostat exhibits antitumor activity and can be used in the study of leukemia and advanced hematologic malignancies.

Tefinostat

Tefinostat

🥰Excellent
Purity: 99.41%
Catalog No. T17028Alias CHR-2845Cas No. 914382-60-8
Tefinostat (CHR-2845) is a potent monocyte/macrophage-targeted histone deacetylase (HDAC) inhibitor that is cleaved to the active acid CHR-2847 by intracellular esterase human carboxylesterase-1 (hCE-1). Tefinostat exhibits antitumor activity and can be used in the study of leukemia and advanced hematologic malignancies.
Pack SizePriceAvailabilityQuantity
1 mg92 €In Stock
5 mg227 €In Stock
10 mg337 €In Stock
25 mg549 €In Stock
50 mg753 €In Stock
100 mg1.064 €In Stock
1 mL x 10 mM (in DMSO)245 €In Stock
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Purity:99.41%
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Product Introduction

Bioactivity
Description
Tefinostat (CHR-2845) is a potent monocyte/macrophage-targeted histone deacetylase (HDAC) inhibitor that is cleaved to the active acid CHR-2847 by intracellular esterase human carboxylesterase-1 (hCE-1). Tefinostat exhibits antitumor activity and can be used in the study of leukemia and advanced hematologic malignancies.
In vitro
Tefinostat (1-4 nM; AML cell lines) demonstrates efficacy in AML cell lines, including HL60 (M2 FAB type), MV411 (M4, FLT3-ITD), OCIAML3 (M4 NPM1mut), and THP1 (M5), with EC50 values of 2.3 μM, 57 nM, 110 nM, and 560 nM, respectively.
AliasCHR-2845
Chemical Properties
Molecular Weight495.61
FormulaC28H37N3O5
Cas No.914382-60-8
SmilesONC(=O)CCCCCCC(=O)Nc1ccc(CN[C@H](C(=O)OC2CCCC2)c2ccccc2)cc1
Relative Density.1.21 g/cm3 (Predicted)
Storage & Solubility Information
Storagestore at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 90 mg/mL (181.59 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.0177 mL10.0886 mL20.1772 mL100.8858 mL
5 mM0.4035 mL2.0177 mL4.0354 mL20.1772 mL
10 mM0.2018 mL1.0089 mL2.0177 mL10.0886 mL
20 mM0.1009 mL0.5044 mL1.0089 mL5.0443 mL
50 mM0.0404 mL0.2018 mL0.4035 mL2.0177 mL
100 mM0.0202 mL0.1009 mL0.2018 mL1.0089 mL

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