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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $118 | In Stock | |
5 mg | $291 | In Stock | |
10 mg | $432 | In Stock | |
25 mg | $715 | In Stock | |
50 mg | $987 | In Stock | |
100 mg | $1,360 | In Stock |
Description | Tefinostat (CHR-2845) is a potent monocyte/macrophage-targeted histone deacetylase (HDAC) inhibitor. Tefinostat is cleaved to the active acid CHR-2847 by the intracellular esterase human carboxylesterase-1 (hCE-1).Tefinostat exhibits antitumor activity and can be used in the study of leukemia and advanced hematologic malignancies. |
In vitro | Tefinostat (1-4 nM; AML cell lines) demonstrates efficacy in AML cell lines, including HL60 (M2 FAB type), MV411 (M4, FLT3-ITD), OCIAML3 (M4 NPM1mut), and THP1 (M5), with EC50 values of 2.3 μM, 57 nM, 110 nM, and 560 nM, respectively. |
Alias | CHR-2845 |
Molecular Weight | 495.61 |
Formula | C28H37N3O5 |
Cas No. | 914382-60-8 |
Storage | store at low temperature,keep away from direct sunlight Powder: -20°C for 3 years | In solvent: -80°C for 1 year | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 90 mg/mL (181.59 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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