Shopping Cart
  • Remove All
  • TargetMol
    Your shopping cart is currently empty

KA2507

🥰Excellent
Catalog No. T9148Cas No. 1636894-46-6

KA2507 is a potent and selective HDAC6 inibitor with an IC50 of 2.5nM.

KA2507

KA2507

🥰Excellent
Purity: 99.14%
Catalog No. T9148Cas No. 1636894-46-6
KA2507 is a potent and selective HDAC6 inibitor with an IC50 of 2.5nM.
Pack SizePriceAvailabilityQuantity
1 mg$41In Stock
5 mg$98In Stock
10 mg$158In Stock
25 mg$286In Stock
50 mg$429In Stock
100 mg$589In Stock
200 mg$796In Stock
1 mL x 10 mM (in DMSO)$29In Stock
Bulk & Custom
Add to Cart
Questions
View More

Related Compound Libraries of "KA2507"

Select Batch
Purity:99.14%
Contact us for more batch information
Resource Download
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Product Introduction

Bioactivity
Description
KA2507 is a potent and selective HDAC6 inibitor with an IC50 of 2.5nM.
Targets&IC50
HDAC6:2.5nm
In vitro
At concentrations selective for HDAC6 inhibition, KA2507 did not inhibit in vitro proliferation of mouse or human cancer cells.
In vivo
KA2507 (100-200 mg/kg; p.o.; daily; for 20 days) inhibits tumor growth in the syngeneic B16-F10 mouse melanoma model and shows antitumor efficacy in CT26 and MC38 colorectal cancer models. Tumor sample analysis reveals that at efficacious doses, KA2507 modulates biomarkers of antitumor immunity, resulting in reduced STAT3 activation (measured by phospho-STAT3), decreased PD-L1 expression, and increased MHC class I expression. However, KA2507 exhibits poor oral bioavailability (mice 15%) and Cmax (mice 300 ng/mL) following oral administration (mice 200 mg/kg). [1]
Chemical Properties
Molecular Weight322.32
FormulaC16H14N6O2
Cas No.1636894-46-6
SmilesONC(=O)c1ccc(CN(c2cnccn2)c2cnccn2)cc1
Relative Density.1.407 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 60 mg/mL (186.15 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.1025 mL15.5125 mL31.0251 mL155.1253 mL
5 mM0.6205 mL3.1025 mL6.2050 mL31.0251 mL
10 mM0.3103 mL1.5513 mL3.1025 mL15.5125 mL
20 mM0.1551 mL0.7756 mL1.5513 mL7.7563 mL
50 mM0.0621 mL0.3103 mL0.6205 mL3.1025 mL
100 mM0.0310 mL0.1551 mL0.3103 mL1.5513 mL

Calculator

  • Molarity Calculator
  • Dilution Calculator
  • Reconstitution Calculator
  • Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
%Tween 80
%ddH2O

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

Related Tags: buy KA2507 | purchase KA2507 | KA2507 cost | order KA2507 | KA2507 chemical structure | KA2507 in vivo | KA2507 in vitro | KA2507 formula | KA2507 molecular weight