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HNHA
🥰Excellent
Catalog No. T21806Cas No. 926908-04-5
HNHA is an inhibitor of HDAC.
HNHA
🥰Excellent
Purity: 98.04%
Catalog No. T21806Cas No. 926908-04-5
HNHA is an inhibitor of HDAC.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $38 | In Stock | |
| 5 mg | $76 | In Stock | |
| 10 mg | $146 | In Stock | |
| 25 mg | $349 | In Stock | |
| 50 mg | $497 | In Stock | |
| 100 mg | $690 | In Stock | |
| 200 mg | $926 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $83 | In Stock |
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Questions
QWhether TargetMol inhibitor products are suitable for industrial use?
AThere are various standards for defining the purity, and we do not have fixed purity standard. The purity of most products are above 98% and can be used for control experiments, including cell experiments, animal experiments, general laboratory experiments, and high-throughput screening. Our product purity also meets the industrial standard.
QWhether sonication is needed for product dissolution? What if I don't have an ultrasound machine?
Asonication can accelerate dissolution. If the compound is not dissolving, sonication is recommended. If you don't have an ultrasound machine, a lower solvent concentration or using less powder are recommended.
QIf the product does not dissolve even when it is below the maximum solubility stated in the instructions, what should I do?
AIt is recommended to utilize some auxiliary dissolution methods, such as heating to 45°C or using sonication to accelerate dissolution.
QHow to choose the appropriate solvent?
ACommon solvents include DMSO, water, ethanol, etc. Please select the appropriate solvent according to the solubility reference. If the inhibitor can be dissolved in DMSO, it is recommended to use freshly opened DMSO without moisture absorption. If the inhibitor can be dissolved in water, solvents like sterile water, physiological saline, sterile PBS ahd culture medium are recommended.
QThe detection results after adding the drug show no effect. Does this indicate a problem with the product quality?
AThe product quality is assured, All products have undergone two rigorous quality inspections. Structural confirmation is achieved through HNMR, while purity is determined by HPLC. However, the same inhibitor may yield different IC50 values and experimental outcomes due to variations in experimental materials (such as cells or animals). Therefore, it's not advisable to directly replicate methods in literature. Instead, establish concentration gradients tailored to your own experiments.
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CitedSelect Batch
Purity:98.04%
Contact us for more batch information
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | HNHA is an inhibitor of HDAC. |
| Targets&IC50 | HDAC:100 nM |
| In vitro | Treatment of cells with HNHA could elicite histone hyperacetylation resulting in an up-regulation of cell cycle arrest, p21 transcription, and an inhibition of HT1080 cell invasion. HNHA was able to inhibit in-vitro HDAC enzyme activity as well as proliferation of human fibrosarcoma cells (HT1080). |
| In vivo | Several HDAC inhibitors, including MS-27-275 and a hydroxyamide-based HDAC inhibitors such as SAHA have been investigated extensively and shown to inhibit tumor growth in vivo. |
| Molecular Weight | 303.42 |
| Formula | C17H21NO2S |
| Cas No. | 926908-04-5 |
| Smiles | ONC(=O)CCCCCCSc1ccc2ccccc2c1 |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
| Solubility Information | Ethanol: 15 mg/mL (49.44 mM), Sonication is recommended. DMSO: 15 mg/mL (49.44 mM), Sonication is recommended. | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
Ethanol/DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Keywords
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