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HNHA
Catalog No. T21806Cas No. 926908-04-5
HNHA is an inhibitor of HDAC.
HNHA
Catalog No. T21806Cas No. 926908-04-5
HNHA is an inhibitor of HDAC.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $63 | In Stock | |
| 2 mg | $89 | In Stock | |
| 5 mg | $127 | In Stock | |
| 10 mg | $243 | In Stock | |
| 25 mg | $581 | In Stock | |
| 50 mg | $829 | In Stock | |
| 100 mg | $1,150 | In Stock | |
| 500 mg | $2,280 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $138 | In Stock |
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Purity:98.04%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | HNHA is an inhibitor of HDAC. |
| Targets&IC50 | HDAC:100 nM |
| In vitro | Treatment of cells with HNHA could elicite histone hyperacetylation resulting in an up-regulation of cell cycle arrest, p21 transcription, and an inhibition of HT1080 cell invasion. HNHA was able to inhibit in-vitro HDAC enzyme activity as well as proliferation of human fibrosarcoma cells (HT1080). |
| In vivo | Several HDAC inhibitors, including MS-27-275 and a hydroxyamide-based HDAC inhibitors such as SAHA have been investigated extensively and shown to inhibit tumor growth in vivo. |
| Molecular Weight | 303.42 |
| Formula | C17H21NO2S |
| Cas No. | 926908-04-5 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||
| Solubility Information | Ethanol: 15 mg/mL (49.44 mM) DMSO: 15 mg/mL (49.44 mM) | |||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||
Ethanol/DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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