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HDAC-IN-52
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Purity:98.5%
HDAC-IN-52
Catalog No. T67878Cas No. 2075787-77-6
HDAC-IN-52, a pyridine-containing HDAC inhibitor, effectively inhibits HDAC1, HDAC2, HDAC3, and HDAC10 with IC50 values of 0.189, 0.227, 0.440, and 0.446 μM, respectively. HDAC-IN-52 can be used in cancer research.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $195 | In Stock | |
| 5 mg | $440 | In Stock | |
| 10 mg | $648 | In Stock | |
| 25 mg | $987 | In Stock | |
| 50 mg | $1,390 | In Stock | |
| 100 mg | $1,870 | In Stock | |
| 500 mg | $3,730 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $486 | In Stock |
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CitedProduct Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | HDAC-IN-52, a pyridine-containing HDAC inhibitor, effectively inhibits HDAC1, HDAC2, HDAC3, and HDAC10 with IC50 values of 0.189, 0.227, 0.440, and 0.446 μM, respectively. HDAC-IN-52 can be used in cancer research. |
| Targets&IC50 | HDAC3:0.440 μM, HDAC1:0.189 μM, HDAC2:0.227 μM, HDAC10:0.446 μM |
| In vitro | HDAC-IN-52 (72 h) inhibited the proliferation of HCT116, A549 and K562 cells with IC50 values of 0.43, 1.28 and 0.37 μM, respectively.[1 ]. HDAC-IN-52 (1-5 μM ; 24-48 h) significantly induced cell death in leukemic U937 cells after 48 h, with 76% and 100% G1 prophase blockade, respectively.[1 ] HDAC-IN-52 (1-5 μM ; 48 h) increased mRNA expression of p21, BAX and BAK and downregulated cyclin D1 and BCL-2.[1 ] |
| Molecular Weight | 396.44 |
| Formula | C24H20N4O2 |
| Cas No. | 2075787-77-6 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 25 mg/mL (63.06 mM)  | ||||||||||||||||||||||||||||||
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