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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $195 | In Stock | |
5 mg | $440 | In Stock | |
10 mg | $648 | In Stock | |
25 mg | $987 | In Stock | |
50 mg | $1,390 | In Stock | |
100 mg | $1,870 | In Stock | |
500 mg | $3,730 | In Stock | |
1 mL x 10 mM (in DMSO) | $486 | In Stock |
Description | HDAC-IN-52, a pyridine-containing HDAC inhibitor, effectively inhibits HDAC1, HDAC2, HDAC3, and HDAC10 with IC50 values of 0.189, 0.227, 0.440, and 0.446 μM, respectively. HDAC-IN-52 can be used in cancer research. |
Targets&IC50 | HDAC3:0.440 μM, HDAC1:0.189 μM, HDAC2:0.227 μM, HDAC10:0.446 μM |
In vitro | HDAC-IN-52 (72 h) inhibited the proliferation of HCT116, A549 and K562 cells with IC50 values of 0.43, 1.28 and 0.37 μM, respectively.[1 ]. HDAC-IN-52 (1-5 μM ; 24-48 h) significantly induced cell death in leukemic U937 cells after 48 h, with 76% and 100% G1 prophase blockade, respectively.[1 ] HDAC-IN-52 (1-5 μM ; 48 h) increased mRNA expression of p21, BAX and BAK and downregulated cyclin D1 and BCL-2.[1 ] |
Molecular Weight | 396.44 |
Formula | C24H20N4O2 |
Cas No. | 2075787-77-6 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
Solubility Information | DMSO: 25 mg/mL (63.06 mM) ![]() | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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