CHDI 00484077, a potent and selective class IIa histone deacetylase (HDAC) inhibitor, demonstrates significant efficacy with IC50 values ranging from 10-30 nM in vivo and specific activity at 0.01 nM and 0.04 nM in HEK293 and Jurkat cells, respectively. It exhibits a 150-fold selectivity for class IIa over class I/IIb HDACs in cellular environments, indicating a high degree of specificity. Additionally, CHDI 00484077 is orally bioavailable and capable of crossing the blood-brain barrier (CNS penetrant).