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BRD6688 is a selective HDAC2 inhibitor that acts by enhancing the learning and memory processes
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $98 | In Stock | |
5 mg | $239 | In Stock | |
10 mg | $378 | In Stock | |
25 mg | $626 | In Stock | |
50 mg | $883 | In Stock | |
100 mg | $1,190 | In Stock |
Description | BRD6688 is a selective HDAC2 inhibitor that acts by enhancing the learning and memory processes |
Targets&IC50 | HDAC3:11.48 μM, HDAC1:21 nM , HDAC2:100 nM |
In vivo | Mouse in-vivo study showed that BRD6688 was able to increase the histone acetylation (H4K12 and H3K9) in hippocampal CA1 neurons of CK-p25 mice. Moreove, the increased histone acetylation in brain served as a surrogate pharmacodynamic marker of HDAC engagement and was consistent with previously observed brain pharmacokinetic properties. In addition, BRD6688 rescued the cognitive deficits in CK-p25 mice, a model of neurodegeneration, in a Pavlovian fear conditioning behavioral assay[1]. |
Molecular Weight | 282.34 |
Formula | C16H18N4O |
Cas No. | 1404562-17-9 |
Smiles | Nc1ccc(cc1NC(=O)N1CCCC1)-c1ccncc1 |
Relative Density. | 1.288 g/cm3 (Predicted) |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | Ethanol: ≤2 mg/mL dimethyl formamide: 30 mg/mL DMSO: 50 mg/mL (177.09 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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