Powder: -20°C for 3 years | In solvent: -80°C for 1 year
BI-3663 is a highly selective PTK2/FAK PROTAC, with cereblon ligands to hijack E3 ligases for PTK2 degradation. BI-3663 inhibits PTK2 with an IC50 of 18 nM. BI-3663 is a PROTAC that composes of BI-4464 linked to Pomalidomide with a linker[1]. Anti-cancer activity[1].
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Description | BI-3663 is a highly selective PTK2/FAK PROTAC, with cereblon ligands to hijack E3 ligases for PTK2 degradation. BI-3663 inhibits PTK2 with an IC50 of 18 nM. BI-3663 is a PROTAC that composes of BI-4464 linked to Pomalidomide with a linker[1]. Anti-cancer activity[1]. |
Targets&IC50 | PTK2/FAK:18 nM (IC50) |
In vitro | BI-3663 potently degrades PTK2 in Hep3B2.1-7 cells, and A549 cells, with pDC50s of 7.6 and 7.9, respectively[1]. |
Molecular Weight | 917.84 |
Formula | C44H42F3N7O12 |
CAS No. | 2341740-84-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 300 mg/mL (326.85 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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BI-3663 2341740-84-7 Others BI3663 BI 3663 inhibitor inhibit