store at low temperature,keep away from direct sunlight
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
CBS9106 (SL-801) is a reversible oral inhibitor of CRM1 with CRM1 degrading and antitumor activities. CBS9106 arrests the cell cycle and inducing apoptosis in a time- and dose-dependent manner for a broad spectrum of cancer cells.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 293.00 | |
5 mg | In stock | $ 722.00 | |
10 mg | In stock | $ 987.00 | |
25 mg | In stock | $ 1,520.00 | |
50 mg | In stock | $ 1,980.00 |
Description | CBS9106 (SL-801) is a reversible oral inhibitor of CRM1 with CRM1 degrading and antitumor activities. CBS9106 arrests the cell cycle and inducing apoptosis in a time- and dose-dependent manner for a broad spectrum of cancer cells. |
In vitro | CBS9106 (1-400 nM; 24 hours) decreases CRM1 protein expression levels in a dose-dependent manner. CBS9106 (0.01-10 μM; 72 hours) sensitizes cells to radiation and to suppress the growth of a variety of cancer cell lines. The estimated IC50 values are range from 22.3 or 35.6 nM in multiple myeloma (MM).1S or RPMI-8226 cells and from 3 to 278 nM in 60 other human cancer cell lines [1]. |
In vivo | In mice bearing human MM xenograft models, CBS9106 (31.25-62.5 mg/kg for 5 times weekly, 125 mg/kg for 3 times weekly; p.o.; 2 weeks) significantly suppresses tumor growth at dose levels of 62.5 or 125 mg/kg. |
Synonyms | SL-801 |
Molecular Weight | 419.83 |
Formula | C18H21ClF3N3O3 |
CAS No. | 1076235-04-5 |
store at low temperature,keep away from direct sunlight
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. More
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CBS9106 1076235-04-5 Membrane transporter/Ion channel CRM1 CBS-9106 SL801 SL 801 CBS 9106 SL-801 inhibitor inhibit