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CNX-774

Catalog No. T2302 CAS 1202759-32-7

Synonyms: CNX 774

CNX-774 is a highly specific, irreversible, and orally active BTK inhibitor (IC50<1 nM).

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CNX-774, CAS 1202759-32-7

Pack Size	Availability	Price/USD
1 mg	In stock	$ 34.00
2 mg	In stock	$ 48.00
5 mg	In stock	$ 80.00
10 mg	In stock	$ 128.00
25 mg	In stock	$ 247.00
50 mg	In stock	$ 409.00
100 mg	In stock	$ 596.00
500 mg	In stock	$ 1,290.00
1 mL * 10 mM (in DMSO)	In stock	$ 85.00

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Purity: 99.1%

Purity: 98.05%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	CNX-774 is a highly specific, irreversible, and orally active BTK inhibitor (IC50<1 nM).
Targets&IC50	BTK:<1 nM
Kinase Assay	In vitro kinase assays: The p38α and p38β are assayed in 25 mM Tris-HCl, pH 7.5, containing 0.1 mM EGTA, with myelin basic protein (0.33 mg/mL) as substrate. Assays are performed either manually for 10 minutes at 30 °C in 50 μL incubations using [γ-33P]ATP, or with a Biomek 2000 Laboratory Automation Workstation in a 96-well format for 40 minutes at ambient temperature in 25 μL incubations using [γ-33P]ATP. The concentrations of ATP and magnesium acetate are 0.1 mM and 10 mM respectively. All assays are initiated with MgATP. Manual assays are terminated by spotting aliquots of incubation on to phosphocellulose paper, followed by immersion in 50 mM phosphoric acid. Robotic assays are terminated by the addition of 5 μL of 0.5 M phosphoric acid before spotting aliquots on to P30 filter mats. All papers are then washed four times in 50 mM phosphoric acid to remove ATP, once in acetone (manual incubations) or methanol (robotic incubations), and then dried and counted for radioactivity.

Synonyms	CNX 774
Molecular Weight	499.5
Formula	C26H22FN7O3
CAS No.	1202759-32-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: 2 mg/mL (4.0 mM)

H2O: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 93 mg/mL (186.2 mM)

References and Literature

1. Labenski M. 17th North Am Meet Int Soc Study Xenobiot (ISSX) 2011. Abst. P211.

Related compound libraries

This product is contained In the following compound libraries：

Tyrosine Kinase Inhibitor Library Inhibitor Library Highly Selective Inhibitor Library Kinase Inhibitor Library Immuno-Oncology Compound Library Covalent Inhibitor Library Orally Active Compound Library Cysteine Covalent Library Bioactive Compound Library Angiogenesis related Compound Library

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RN486 Avitinib TAK-020 Syk Inhibitor II dihydrochloride ACP-5862 Spebrutinib besylate Rilzabrutinib RSH-7

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

CNX-774 1202759-32-7 Angiogenesis Tyrosine Kinase/Adaptors BTK Bruton tyrosine kinase Btk B-cell CNX 774 BCR Inhibitor inhibit CNX774 autoimmune inhibitor

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