BTK

Bruton's tyrosine kinase (abbreviated Btk or BTK), also known as tyrosine-protein kinase BTK, is a tyrosine kinase that is encoded by the BTK gene in humans. BTK plays a crucial role in B cell development.

Cat. No.	Product name	CAS No.	Purity
T9814	JAK3/BTK-IN-1	2674036-91-8	98%
T9814	JAK3/ BTk-in-1 is a dual JAK3/BTK inhibitor that specifically targets and inhibits Janus kinase 3 (JAK3) and Bruton's tyrosine kinase (BTK), two important target...
T9813	JAK3/BTK-IN-2	2674036-93-0	98%
T9813	JAK3/ BTk-in-2 is a potent JAK3/BTK inhibitor. JAK3/ BTk-in-2 inhibits both BTK and JAK3, which are two important targets IN autoimmune diseases. JAK3/ BTk-in-2 ...
T63272	Edralbrutinib	1858206-58-2	98%
T63272	Edralbrutinib is a potent BTK inhibitor with anticancer activity and is used in the treatment of tumors, immune system disorders, and blood and lymphatic system ...
T35330	BTK inhibitor 1	2230724-66-8	98%
T35330	BTK inhibitor 1 (Compound 27) is a BTK inhibitor (IC50: 0.11 nM) with an inhibitory effect on B-cell activation in hWB with an IC50 of 2 nM.
T10870L	CP-547632	252003-65-9	98%
T10870L	CP-547632 is an orally available and potent, ATP-competitive dual inhibitor of VEGFR-2 and FGF kinase F with IC50s of 11 nM and 9 nM, respectively. CP-547632 is ...
T38960	QL-X-138	1469988-63-3	98%
T38960	QL-X-138 is a potent and selective BTK and MNK dual kinase inhibitor that binds covalently to BTK and non-covalently to MNK.The IC 50 s of QL-X-138 against BTK, ...
T16265	Naluzotan	740873-06-7	98%
T16265	Naluzotan is an effective and selective amidosulfonamide 5-HT1A agonist with IC50 and Ki of appr 20 nM and 5.1 nM. Naluzotan is used for the treatment of anxiety...
T39707	AS-1763	2227211-00-7	98%
T39707	AS-1763 is an orally available and selective BTK inhibitor with an IC50 of 0.85 nM.
T15365	G-744	1346669-54-2	98%
T15365	G-744 is a selective and orally active inhibitor of Btk (IC50: 2 nM). G-744 is well-tolerated, metabolically stable. It also has an efficacious to treat arthriti...
T12152	N-piperidine Ibrutinib hydrochloride	2231747-18-3	98%
T12152	N-piperidine Ibrutinib hydrochloride is an potent inhibitor of BTK (WT BTK and C481S BTK with IC50s of 51.0 and 30.7 nM, respectively).
T10240	ACP-5862	2230757-47-6	98%
T10240	ACP-5862 is a major active and pyrrolidine ring-opened metabolite of Acalabrutinib (IC50: 5.0 nM for BTK). Acalabrutinib is an irreversible and highly selective ...
T12673L	PF-06250112	1609465-89-5	98%
T12673L	PF-06250112 is an effective and highly selective BTK inhibitor (IC50: 0.5 nM. PF-06250112 displays an inhibitory effect toward BMX nonreceptor tyrosine kinase an...
T14357	Spebrutinib besylate	1360053-81-1	98%
T14357	Spebrutinib besylate (AVL-292 benzenesulfonate; CC-292 besylate) is a Btk kinase activity inhibitor (IC50<0.5 nM, Kinact/Ki=7.69×104 M-1s-1s).
T16853	SB-633825	956613-01-7	98%
T16853	SB-633825 can inhibit cancer cell growth and angiogenesis. SB-633825 is an effective and ATP-competitive inhibitor of TIE2, LOK, and BRK (IC50s: 3.5 nM, 66 nM, 1...
T14956	CHMFL-BTK-01	2095280-64-9	98%
T14956	CHMFL-BTK-01 is an irreversible inhibitor of BTK (IC50: 7 nM) and also potently inhibits BTK Y223 auto-phosphorylation.
T16441	PCI-33380	1022899-36-0	98%
T16441	PCI-33380 is an irreversible inhibitor of Bruton's Tyrosine Kinase.
T11379	GDC-0834	1133432-49-1	98%
T11379	GDC-0834 inhibits BTK with an in vitro IC50 of 5.9 and 6.4 nM in biochemical and cellular assays, respectively, and in vivo IC50 of 1.1 and 5.6 μM in mouse and r...
T6217	LFM-A13	244240-24-2	98%
T6217	LFM-A13（IC50=2.5 μM）, a specific Bruton's tyrosine kinase (BTK), is more than 100-fold specificity than other protein kinases, such as JAK1, JAK2, HCK, EGFR, and...
T14681	BMS-935177	1231889-53-4	98%
T14681	BMS-935177 is a reversible BTK inhibitor with IC50 value of 3 nM.
T10625	IBT6A	1022150-12-4	98%
T10625	IBT6A is an impurity of Ibrutinib. Ibrutinib is a Btk inhibitor (IC50: 0.5 nM). IBT6A can be used in the synthesis of IBT6A Ibrutinib dimer and IBT6A adduct.