BTK

Bruton's tyrosine kinase (abbreviated Btk or BTK), also known as tyrosine-protein kinase BTK, is a tyrosine kinase that is encoded by the BTK gene in humans. BTK plays a crucial role in B cell development.

Cat. No.	Product name	CAS No.	Purity
TQ0039	(±)-Zanubrutinib	1633350-06-7	98%
TQ0039	(±)-Zanubrutinib is a specific, potent and orally available Btk inhibitor.
T10240	ACP-5862	2230757-47-6	98%
T10240	ACP-5862 is a major active and pyrrolidine ring-opened metabolite of Acalabrutinib (IC50: 5.0 nM for BTK). Acalabrutinib is an irreversible and highly selective ...
T12673L	PF-06250112	1609465-89-5	98%
T12673L	PF-06250112 is an effective and highly selective BTK inhibitor (IC50: 0.5 nM. PF-06250112 displays an inhibitory effect toward BMX nonreceptor tyrosine kinase an...
T12152	N-piperidine Ibrutinib hydrochloride	2231747-18-3	98%
T12152	N-piperidine Ibrutinib hydrochloride is an potent inhibitor of BTK (WT BTK and C481S BTK with IC50s of 51.0 and 30.7 nM, respectively).
T14357	Spebrutinib besylate	1360053-81-1	98%
T14357	Spebrutinib besylate (AVL-292 benzenesulfonate; CC-292 besylate) is a Btk kinase activity inhibitor (IC50<0.5 nM, Kinact/Ki=7.69×104 M-1s-1s).
T14956	CHMFL-BTK-01	2095280-64-9	98%
T14956	CHMFL-BTK-01 is an irreversible inhibitor of BTK (IC50: 7 nM) and also potently inhibits BTK Y223 auto-phosphorylation.
T16853	SB-633825	956613-01-7	98%
T16853	SB-633825 can inhibit cancer cell growth and angiogenesis. SB-633825 is an effective and ATP-competitive inhibitor of TIE2, LOK, and BRK (IC50s: 3.5 nM, 66 nM, 1...
T11379	GDC-0834	1133432-49-1	98%
T11379	GDC-0834 inhibits BTK with an in vitro IC50 of 5.9 and 6.4 nM in biochemical and cellular assays, respectively, and in vivo IC50 of 1.1 and 5.6 μM in mouse and r...
T9814	JAK3/BTK-IN-1	2674036-91-8	98%
T9814	JAK3/BTK-IN-1 is a potent inhibitor of JAK3 / BTK. BTK and JAK3 are two important targets for autoimmune diseases. Simultaneous inhibition of the BTK/JAK3 signal...
T35330	BTK inhibitor 1 (Compound 27)	2230724-66-8	98%
T35330	BTK inhibitor 1 (compound 27) is an inhibitor ofBTKwith an IC50 of 0.11 nM for Btk and inhibits B cell activation in hWB with an IC50 of 2 nM.
T15365	G-744	1346669-54-2	98%
T15365	G-744 is a selective and orally active inhibitor of Btk (IC50: 2 nM). G-744 is well-tolerated, metabolically stable. It also has an efficacious to treat arthriti...
T16441	PCI-33380	1022899-36-0	98%
T16441	PCI-33380 is an irreversible inhibitor of Bruton's Tyrosine Kinase.
T16265	Naluzotan	740873-06-7	98%
T16265	Naluzotan is an effective and selective amidosulfonamide 5-HT1A agonist with IC50 and Ki of appr 20 nM and 5.1 nM. Naluzotan is used for the treatment of anxiety...
TQ0236	Tirabrutinib	1351636-18-4	98%
TQ0236	Tirabrutinib (ONO-4059) is a highly specific and orally bioavailable BTK inhibitor (IC50: 2.2 nM).
T13564	AZ7550	1421373-99-0	98%
T13564	AZ7550, an active metabolite of AZD9291, inhibits the activity of IGF1R (IC50: 1.6 μM).
T9705	TL-895	1415823-49-2	98%
T9705	TL-895 is an ATP-competitive, and highly selective irreversible inhibitor of Bruton’s Tyrosine Kinase(BTK). TL-895 showed good potency with an IC50 of 1.5 nM and...
T14692	BMX-IN-1	1431525-23-3	98%
T14692	BMX-IN-1 is a selective inhibitor of bone marrow tyrosine kinase on chromosome X (BMX, IC50 = 8 nM) and the related Bruton’s tyrosine kinase (BTK, IC50 = 10.4 nM...
T9813	JAK3/BTK-IN-2	2674036-93-0	98%
T9813	JAK3/BTK-IN-2 is a potent inhibitor of JAK3 / BTK. BTK and JAK3 are two important targets for autoimmune diseases. Simultaneous inhibition of the BTK/JAK3 signal...
T2603	Spebrutinib	1202757-89-8	97.14%
T2603	Spebrutinib is an orally bioavailable, selective inhibitor of Bruton's agammaglobulinemia tyrosine kinase (BTK), with potential antineoplastic activity.
T4268	CHMFL-BMX-078	1808288-51-8	98%
T4268	CHMFL-BMX-078 is a highly potent and selective type II irreversible BMX kinase inhibitor with an IC50 of 11 nM.