Shopping Cart
- Remove All
![TargetMol](https://www.targetmol.com/storage/error/oops.webp)
Your shopping cart is currently empty
Pack Size | Price | Availability | Quantity |
---|---|---|---|
2 mg | $198 | 7-10 days | |
5 mg | $399 | 7-10 days | |
1 mL x 10 mM (in DMSO) | $546 | 7-10 days |
Description | GDC-0834 inhibits BTK with an in vitro IC50 of 5.9 and 6.4 nM in biochemical and cellular assays, respectively, and in vivo IC50 of 1.1 and 5.6 μM in mouse and rat, respectively. GDC-0834 is a potent and selective BTK inhib |
In vitro | GDC-0834 is shown to be a potent reversible inhibitor of six known aldehyde oxidase (AO) substrates with IC50 values ranging from 0.86 to 1.87 μM.?GDC-0834 suppresses BTK kinase activity with an IC50 value of 5.9±1.1 nM with Hill slope value of ?0.84±0.07 (mean±S.E.). |
In vivo | In a rat collagen-induced arthritis (CIA) study, GDC-0834 exhibits a dose-dependent inhibition of phosphorylated Bruton's tyrosine kinase (pBTK-Tyr223) in rat blood. The estimated half-maximal inhibitory concentration (IC50) for pBTK-Tyr223 inhibition in rats is 5.6±1.6 μM, demonstrating a moderate potency with a mean (m) value of 0.51±0.087. Furthermore, treatment with GDC-0834 in BALB/c mice demonstrates dose-dependent suppression of pBTK-Tyr223, with dosages of 150 or 100 mg/kg achieving nearly complete inhibition (97% and 96%, respectively) of pBTK-Tyr223 levels in the blood after 2 hours. |
Molecular Weight | 596.74 |
Formula | C33H36N6O3S |
Cas No. | 1133432-49-1 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | ||||||||||||||||||||||||||||||
Solubility Information | DMSO: 32 mg/mL (53.62 mM) | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
|
Copyright © 2015-2024 TargetMol Chemicals Inc. All Rights Reserved.