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GDC-0834 (racemate) is the racemate form of GDC-0834, an effective and selective BTK inhibitor.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
2 mg | $98 | 5 days | |
5 mg | $214 | 5 days | |
50 mg | $723 | 6-8 weeks | |
100 mg | $996 | 6-8 weeks |
Description | GDC-0834 (racemate) is the racemate form of GDC-0834, an effective and selective BTK inhibitor. |
In vitro | GDC-0834 inhibited BTK (IC50s: 5.9 and 6.4 nM in biochemical and cellular assays) and (IC50s: 1.1 and 5.6 μM in mouse and rat) [1]. |
In vivo | Administration of GDC-0834 (30-100 mg/kg) in a rat collagen-induced arthritis (CIA) model resulted in a dose-dependent decrease of ankle swelling and reduction of morphologic pathology [1]. GDC-0834 exhibited low clearance in PXB chimeric mice with humanized liver. GDC-0834 plasma concentrations in humans were below the limit of quantitation (<1 ng/ml) in most samples from the cohorts dosed orally at 35 and 105 mg [2]. |
Molecular Weight | 596.74 |
Formula | C33H36N6O3S |
Cas No. | 1133432-46-8 |
Relative Density. | 1.35 g/cm3 (Predicted) |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
Solubility Information | DMSO: 49 mg/mL (82.11 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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