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PCI 29732

🥰Excellent
Catalog No. T4337Cas No. 330786-25-9
Alias PCI-29732, PCI29732

PCI 29732 is a selective and irreversible Btk inhibitor with IC50 of 8.2 nM in a FRET based biochemical enzymology assay.

PCI 29732

PCI 29732

🥰Excellent
Purity: 99.79%
Catalog No. T4337Alias PCI-29732, PCI29732Cas No. 330786-25-9
PCI 29732 is a selective and irreversible Btk inhibitor with IC50 of 8.2 nM in a FRET based biochemical enzymology assay.
Pack SizePriceAvailabilityQuantity
1 mg$34In Stock
2 mg$48In Stock
5 mg$80In Stock
10 mg$128In Stock
25 mg$252In Stock
50 mg$449In Stock
100 mg$659In Stock
1 mL x 10 mM (in DMSO)$89In Stock
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Purity:99.79%
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Product Introduction

Bioactivity
Description
PCI 29732 is a selective and irreversible Btk inhibitor with IC50 of 8.2 nM in a FRET based biochemical enzymology assay.
Targets&IC50
BTK:8.2 nM
In vitro
PCI 29732(compound 1) has a 8.2 nM potency against Btk in a FRET based biochemical enzymology assay. PCI 29732 shows only modest inhibitory activity against Itk, another Tec family kinase, probably due to the difference at the 'gatekeeper” residue. In human CD20+ B cells stimulated at the BCR, PCI-29732 blocked the transcriptional up-regulation of a panel of B-cell activation genes that occurs within 6 h of stimulation. Pulse exposure to the reversible inhibitor PCI-29732 did not result in BCR inhibition.
AliasPCI-29732, PCI29732
Chemical Properties
Molecular Weight371.43
FormulaC22H21N5O
Cas No.330786-25-9
SmilesNc1ncnc2n(nc(-c3ccc(Oc4ccccc4)cc3)c12)C1CCCC1
Relative Density.1.36 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 55 mg/mL (148.08 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.6923 mL13.4615 mL26.9230 mL134.6149 mL
5 mM0.5385 mL2.6923 mL5.3846 mL26.9230 mL
10 mM0.2692 mL1.3461 mL2.6923 mL13.4615 mL
20 mM0.1346 mL0.6731 mL1.3461 mL6.7307 mL
50 mM0.0538 mL0.2692 mL0.5385 mL2.6923 mL
100 mM0.0269 mL0.1346 mL0.2692 mL1.3461 mL

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