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BMX-IN-1

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Catalog No. T14692Cas No. 1431525-23-3
Alias BMX kinase inhibitor

BMX-IN-1 (BMX kinase inhibitor) is a selective inhibitor of bone marrow tyrosine kinase on chromosome X (BMX, IC50 = 8 nM) and the related Bruton's tyrosine kinase (BTK, IC50 = 10.4 nM), but BMX-IN-1 is more than 47-656 fold less potent against Blk, JAK3, EGFR, Itk, or Tec activity.

BMX-IN-1

BMX-IN-1

🥰Excellent
Catalog No. T14692Alias BMX kinase inhibitorCas No. 1431525-23-3
BMX-IN-1 (BMX kinase inhibitor) is a selective inhibitor of bone marrow tyrosine kinase on chromosome X (BMX, IC50 = 8 nM) and the related Bruton's tyrosine kinase (BTK, IC50 = 10.4 nM), but BMX-IN-1 is more than 47-656 fold less potent against Blk, JAK3, EGFR, Itk, or Tec activity.
Pack SizePriceAvailabilityQuantity
1 mg$30 In Stock
5 mg$77 In Stock
10 mg$119 In Stock
25 mg$248 In Stock
50 mg$347 In Stock
100 mg$476 In Stock
1 mL x 10 mM (in DMSO)$95 In Stock
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Product Introduction

Bioactivity
Description
BMX-IN-1 (BMX kinase inhibitor) is a selective inhibitor of bone marrow tyrosine kinase on chromosome X (BMX, IC50 = 8 nM) and the related Bruton's tyrosine kinase (BTK, IC50 = 10.4 nM), but BMX-IN-1 is more than 47-656 fold less potent against Blk, JAK3, EGFR, Itk, or Tec activity.
Targets&IC50
BMX:8 nM, BTK:10.4 nM
In vitro
BMX-IN-1 inhibits only wild-type BMX with an IC50 of 138 nM. BMX-IN-1 inhibits the proliferation of Tel-BMX-transformed Ba/F3 cells and RV-1 cells with IC50s of 25 nM and 2.53 μM. BMX-IN-1 exhibits remarkable selectivity with an S(10) score of 0.01[1].
AliasBMX kinase inhibitor
Chemical Properties
Molecular Weight524.59
FormulaC29H24N4O4S
Cas No.1431525-23-3
SmilesCc1ccc(cc1NC(=O)C=C)-n1c2c(ccc1=O)cnc1ccc(cc21)-c1ccc(NS(C)(=O)=O)cc1
Relative Density.1.397 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMF: 9 mg/mL (17.16 mM), Sonication is recommended.
DMSO: 8 mg/mL (15.25 mM), Sonication is recommended.
Solution Preparation Table
DMSO/DMF
1mg5mg10mg50mg
1 mM1.9063 mL9.5313 mL19.0625 mL95.3125 mL
5 mM0.3813 mL1.9063 mL3.8125 mL19.0625 mL
10 mM0.1906 mL0.9531 mL1.9063 mL9.5313 mL

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