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BMX-IN-1

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COA HNMR

BMX-IN-1

Catalog No. T14692Cas No. 1431525-23-3

BMX-IN-1 (BMX kinase inhibitor) is a selective inhibitor of bone marrow tyrosine kinase on chromosome X (BMX, IC50 = 8 nM) and the related Bruton’s tyrosine kinase (BTK, IC50 = 10.4 nM), but BMX-IN-1 is more than 47-656 fold less potent against Blk, JAK3, EGFR, Itk, or Tec activity.

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Pack Size	Price	Availability
1 mg	$48	In Stock
5 mg	$128	In Stock
10 mg	$198	In Stock
25 mg	$413	In Stock
50 mg	$579	In Stock
100 mg	$793	In Stock
1 mL x 10 mM (in DMSO)	$158	In Stock

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Product Introduction

Bioactivity

Description	BMX-IN-1 (BMX kinase inhibitor) is a selective inhibitor of bone marrow tyrosine kinase on chromosome X (BMX, IC50 = 8 nM) and the related Bruton’s tyrosine kinase (BTK, IC50 = 10.4 nM), but BMX-IN-1 is more than 47-656 fold less potent against Blk, JAK3, EGFR, Itk, or Tec activity.
In vitro	BMX-IN-1 inhibits only wild-type BMX with an IC50 of 138 nM. BMX-IN-1 inhibits the proliferation of Tel-BMX-transformed Ba/F3 cells and RV-1 cells with IC50s of 25 nM and 2.53 μM. BMX-IN-1 exhibits remarkable selectivity with an S(10) score of 0.01[1].
Alias	BMX kinase inhibitor

Chemical Properties

Molecular Weight	524.59
Formula	C29H24N4O4S
Cas No.	1431525-23-3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMF: 9 mg/mL (17.16 mM)

DMSO: 8 mg/mL (15.25 mM)

Solution Preparation Table

DMF/DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9063 mL	9.5313 mL	19.0625 mL	95.3125 mL
5 mM	0.3813 mL	1.9063 mL	3.8125 mL	19.0625 mL
10 mM	0.1906 mL	0.9531 mL	1.9063 mL	9.5313 mL

DMF

	1mg	5mg	10mg	50mg
20 mM	0.0953 mL	0.4766 mL	0.9531 mL	4.7656 mL
50 mM	0.0381 mL	0.1906 mL	0.3813 mL	1.9063 mL
100 mM	0.0191 mL	0.0953 mL	0.1906 mL	0.9531 mL

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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc