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RSH-7
Catalog No. T73549Cas No. 2764609-97-2
RSH-7 is a potent dual inhibitor of BTK and FLT3, with IC50s of 47 and 12 nM, respectively.RSH-7 has antiproliferative and antitumor activities, inducing apoptosis and inhibiting BTK and FLT3 signaling.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $97 | In Stock | |
| 5 mg | $263 | In Stock | |
| 10 mg | $428 | In Stock | |
| 25 mg | $813 | In Stock | |
| 50 mg | $1,180 | In Stock | |
| 100 mg | $1,620 | In Stock | |
| 500 mg | $3,230 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | RSH-7 is a potent dual inhibitor of BTK and FLT3, with IC50s of 47 and 12 nM, respectively.RSH-7 has antiproliferative and antitumor activities, inducing apoptosis and inhibiting BTK and FLT3 signaling. |
| Targets&IC50 | BTK:47 nM, FLT3:12 nM |
| In vitro | RSH-7 (1-1000 nM; 72 h) exhibits antiproliferative activities for Jeko-1, MV-4-11, Molt4, and K562 cells with IC50 values of 17 nM, 3 nM, 11 nM, and 930 nM respectively.[1] RSH-7 (1-1000 nM; 72 h) dose-dependently reduces the expression of p-BTK (TYR223), p-PLCγ(Tyr1217), p-FLT3 (Tyr589), and p-STAT5 (TYR694).[1] RSH-7 (1-1000 nM; 72 h) dose-dependently triggers apoptosis and upregulates the expression of BAX, p53, and cleaved caspase 3 in Jeko-1 cells.[1] |
| In vivo | RSH-7 (25, 50 mg/kg; i.p.; daily for 16 days; Female NOD/SCID mice) suppressed tumor growth in a dose-dependent manner, with tumor growth inhibition (TGI) values of 66.95% and 79.78% at doses of 25 and 50 mg/kg.[1] |
| Molecular Weight | 436.49 |
| Formula | C22H25FN8O |
| Cas No. | 2764609-97-2 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 75 mg/mL (171.83 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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