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SB-633825
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Catalog No. T16853Cas No. 956613-01-7
SB-633825 can inhibit cancer cell growth and angiogenesis. SB-633825 is an effective and ATP-competitive inhibitor of TIE2, LOK, and BRK (IC50s: 3.5 nM, 66 nM, 150 nM, respectively).
SB-633825
😃Good
Catalog No. T16853Cas No. 956613-01-7
SB-633825 can inhibit cancer cell growth and angiogenesis. SB-633825 is an effective and ATP-competitive inhibitor of TIE2, LOK, and BRK (IC50s: 3.5 nM, 66 nM, 150 nM, respectively).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 2 mg | $196 | 5 days | |
| 5 mg | $393 | 5 days | |
| 25 mg | $1,200 | 6-8 weeks | |
| 50 mg | $1,570 | 6-8 weeks | |
| 100 mg | $2,500 | 6-8 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | SB-633825 can inhibit cancer cell growth and angiogenesis. SB-633825 is an effective and ATP-competitive inhibitor of TIE2, LOK, and BRK (IC50s: 3.5 nM, 66 nM, 150 nM, respectively). |
| Targets&IC50 | Tie2:3.5 nM, Brk:150 nM, LOK:66 nM |
| In vitro | SB-633825 (0.1 μM) inhibits LOK to 44% maximal activity and TIE2 to 75% maximal activity. SB-633825 inhibits TIE2 Tyrosine-protein kinase, lymphocyte-oriented kinase (LOK; STK10), and breast tumor kinase (Brk; PTK6) [1]. |
| Molecular Weight | 483.58 |
| Formula | C28H25N3O3S |
| Cas No. | 956613-01-7 |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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