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Carotegrast methyl

Catalog No. T30751 CAS 401905-67-7

Synonyms: AJM300

Carotegrast methyl (AJM300), an orally-active small molecule, can antagonize the α4 integrin receptor. It is a specific and dual α4β1/α4β7 integrin antagonist.

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Carotegrast methyl, CAS 401905-67-7

Pack Size	Availability	Price/USD
1 mg	In stock	$ 77.00
5 mg	In stock	$ 189.00
10 mg	In stock	$ 313.00
25 mg	In stock	$ 622.00
50 mg	In stock	$ 955.00
100 mg	In stock	$ 1,390.00
1 mL * 10 mM (in DMSO)	In stock	$ 226.00

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Purity: 98.73%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Carotegrast methyl (AJM300), an orally-active small molecule, can antagonize the α4 integrin receptor. It is a specific and dual α4β1/α4β7 integrin antagonist.

Synonyms	AJM300
Molecular Weight	569.44
Formula	C28H26Cl2N4O5
CAS No.	401905-67-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 100 mg/mL (175.61 mM), Sonication is recommended.

References and Literature

1. Zhao W, Xu L, Li D, Li X, Wang C, Zheng M, Pan C, Qiu L. Biodegradation of thifensulfuron-methyl by Ochrobactrum sp. in liquid medium and soil. Biotechnol Lett. 2015 Jul;37(7):1385-92. doi: 10.1007/s10529-015-1807-3. Epub 2015 Mar 15. PubMed PMID: 25773196. 2. Blessy JJ, Sharmila DJ. Molecular modeling of methyl-α-Neu5Ac analogues docked against cholera toxin--a molecular dynamics study. Glycoconj J. 2015 Feb;32(1-2):49-67. doi: 10.1007/s10719-014-9570-6. Epub 2015 Feb 13. PubMed PMID: 25676314. 3. Bell JG, Green JR, Wang J. Complex reaction dynamics in the cerium-bromate-2-methyl-1,4-hydroquinone photoreaction. J Phys Chem A. 2014 Oct 23;118(42):9795-800. doi: 10.1021/jp505378r. Epub 2014 Oct 13. PubMed PMID: 25279948. 4. Vogt M, Brüsseler C, Ooyen JV, Bott M, Marienhagen J. Production of 2-methyl-1-butanol and 3-methyl-1-butanol in engineered Corynebacterium glutamicum. Metab Eng. 2016 Nov;38:436-445. doi: 10.1016/j.ymben.2016.10.007. Epub 2016 Oct 14. PubMed PMID: 27746323.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Drug Repurposing Compound Library Immunology/Inflammation Compound Library Bioactive Compounds Library Max Clinical Compound Library ReFRAME Related Library Orally Active Compound Library Cytoskeletal Signaling Pathway Compound Library Bioactive Compound Library NO PAINS Compound Library

Related Products

Related compounds with same targets

RGD peptide (GRGDNP) Bersanlimab Roxifiban acetate β-glycosidase-IN-1 Hexapeptide-10 Acetate BTT-3033 Bestatin hydrochloride Pyrintegrin

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Carotegrast methyl 401905-67-7 Cytoskeletal Signaling Integrin RPMI-8866 HCA2969 Jurkat inhibit TK-1 colitis AJM-300 Inhibitor AJM300 AJM 300 orally inhibitor

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