Integrin

Integrins are proteins that function mechanically, by attaching the cell cytoskeleton to the extracellular matrix (ECM), and biochemically, by sensing whether adhesion has occurred. The integrin family of proteins consists of alpha and beta subtypes, which form transmembrane heterodimers.

Cat. No.	Product name	CAS No.	Purity
T13473L	αvβ1 integrin-IN-1 TFA (1689540-62-2 free base)	T13473L	98%
T13473L	αvβ1 integrin-IN-1 TFA is an effective and selective αvβ1 integrin inhibitor (IC50: 0.63 nM).
T78029	REDV TFA		98%
T78029	REDV TFA, the minimal active sequence of the CS5 site in the alternatively spliced type III connecting segment (IIICS) of fibronectin, mediates adhesion to the I...
T78064	Synstatin (92-119)	1259384-47-8	98%
T78064	Synstatin (92-119) serves as an anti-tumor agent by suppressing angiogenesis and cancer cell invasion, chiefly through the down-regulation of integrin αvβ3 and a...
T78219	Obtustatin triacetate		98%
T78219	Obtustatin triacetate, a 41-residue non-RGD disintegrin isolated from the venom of Vipera lebetina obtusa, serves as a potent and selective inhibitor of the inte...
T78548	3-Hydroxyxanthone	3722-51-8	98%
T78548	3-Hydroxyxanthone (3-Hydroxy-xanthen-9-one), a xanthone derivative, exhibits inhibitory effects on NADPH-catalyzed lipid peroxidation in human umbilical vein end...
T78666	Egaptivon pegol	934868-74-3	98%
T78666	Egaptivon pegol (ARC1779) is an aptamer that inhibits the interaction of von Willebrand Factor (VWF) with platelet GPIb receptors, exhibiting anti-thrombotic eff...
T79140	αvβ6 integrin inhibitor 2	313709-47-6	98%
T79140	αvβ6 Integrin Inhibitor 2 is a potent inhibitor of αvβ6 integrin, demonstrating an inhibition concentration (IC50) of 96.5 nM, as detailed in WO2020081154A1, exa...
T79188	BT100		98%
T79188	BT100, an aptamer, impedes the interaction of von Willebrand factor (VWF) with platelet glycoprotein GPIb, thus obstructing arterial thrombosis [1].
T79792	αvβ1 integrin-IN-2	2234874-68-9	98%
T79792	αvβ1 integrin-IN-2 (compound 32) is a potent inhibitor of ανβ1 and α5β1 integrins, exhibiting IC50 values of 0.9 nM and 33 nM, respectively. Additionally, this c...
T79918	α7β1 integrin modulator-1	849121-82-0	98%
T79918	α7β1 Integrin Modulator-1 is a potent modulator with research potential for muscular dystrophy [1].
T80075	Cyclo(Ala-Arg-Gly-Asp-Mamb)	153381-95-4	98%
T80075	Cyclo(Ala-Arg-Gly-Asp-Mamb) is a selective antagonist of the RGD peptide with potential applications in pulmonary arterial hypertension research [1].
T80127	FITC-Ahx-Gly-Arg-Gly-Asp-Ser-Pro	2022956-44-9	98%
T80127	FITC-Ahx-Gly-Arg-Gly-Asp-Ser-Pro, also known as FITC-linked GRGDSP, is a fluorescent peptide with integrin inhibitory properties. This compound impedes tumor cel...
T80142	Cyclo(Gly-Arg-Gly-Asp-Ser-Pro)	135432-37-0	98%
T80142	Cyclo(Gly-Arg-Gly-Asp-Ser-Pro) (c(GRGDSP)) is an RGD-containing inhibitory peptide and a synthetic α5β1 integrin ligand. It competitively inhibits the binding of...
T80214	CRGDfK-thioacetyl ester	393781-65-2	98%
T80214	cRGDfK-thioacetyl ester, a bioactive polypeptide, exhibits selective affinity for integrins and can modify near-infrared (NIR) fluorescent probes for targeted ca...
T80529	VnP-16		98%
T80529	VnP-16 enhances bone formation by stimulating the differentiation and activity of osteoblasts via direct β1 integrin engagement, which subsequently activates FAK...
T80586	Anti-Mouse IL-1a Antibody (ALF-161)		98%
T80586	Anti-Mouse IL-1a Antibody is an IgG1 subtype inhibitor specific to mouse IL-1a, derived from the Armenian Hamster.
T81754	MP6	2700321-79-3	98%
T81754	mP6 (Myr-FEEERA-OH), a myristoylated peptide, selectively inhibits Gα 13's interaction with integrin β 3 while preserving talin-dependent integrin function. Addi...
T8726	Cyclo(RGDyK)	217099-14-4	98%
T8726	Cyclo(RGDyK) is a potent and selective αVβ3 integrin inhibitor with IC50 of 20 nM.
TP2148	LXW7 TFA (1313004-77-1 free base)	TP2148	98%
TP2148	LXW7 TFA, a cyclic peptide containing Arg-Gly-Asp (RGD), is an integrin αvβ3 inhibitor with an anti-inflammatory effect. LXW7 has a high binding affinity to αvβ3...
T14558	BI-1950	1159724-42-1	98%
T14558	BI-1950 is a highly potent lymphocyte function associated antigen-1 (LFA-1) inhibitor and the LFA-1 is an essential component in normal immune system function an...