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Cytoskeletal Signaling Integrin

Integrin

Integrins are proteins that function mechanically, by attaching the cell cytoskeleton to the extracellular matrix (ECM), and biochemically, by sensing whether adhesion has occurred. The integrin family of proteins consists of alpha and beta subtypes, which form transmembrane heterodimers.
Cat No. product name
T0342 Carvedilol phosphate Carvedilol Phosphate is the phosphate salt form of carvedilol, a racemic mixture and adrenergic blocking agent with antihypertensive activity and devoid of intr...
T0447 Carvedilol Carvedilol Phosphate is the phosphate salt form of carvedilol, a racemic mixture and adrenergic blocking agent with antihypertensive activity and devoid of intr...
T2254 A-205804 A-205804 is a specific and effective inhibitor of E-selectin( IC50=20 nM ) and ICAM-1(IC50=25 nM) expression.
T2494 Cilengitide Cilengitide is a potent integrin inhibitor for the αvβ3/5 receptor (IC50: 4.1/79 nM, in cell-free assays); ~10-fold selectivity against gpIIbIIIa.
T2537 Tirofiban hydrochloride monohydrate Tirofiban hydrochloride monohydrate is a potent non-peptide, glycoprotein IIb/IIIa (integrins alphaIIbbetaIII) antagonist.
T3529 Bestatin hydrochloride Bestatin (Ubenimex) hydrochlorideis an inhibitor of aminopeptidase N (APN)/CD13 and aminopeptidase B.
T3638 Leukadherin-1 Leukadherin-1 is an allosteric activator of CD11b/CD18. Increasing CD11b/CD18-dependent cell adhesion to fibrinogen, Decreasing leukocyte motility and transendo...
T3881 Vaccarin Vaccarin is a major flavonoid glycoside in Vaccariae semen, its biotransformation pathways involves methylation, hydroxylation, glycosylation and deglycosylatio...
T3977 Lifitegrast Lifitegrast is a lymphocyte, function-associated antigen-1 antagonist.
T6182 Tirofiban Tirofiban (MK-383) is a selective palate GPIIb/IIIa antagonist which inhibits platelet aggregation with IC50 of 9 nM.
T6812 Cyclo (-RGDfK) Cyclo (-RGDfK) is an effective and specific αvβ3 integrin inhibitor.
T6813 Cyclo(RGDyK) Cyclo(RGDyK) is a potent and selective αVβ3 integrin inhibitor with IC50 of 20 nM.
T6966 RGD Peptides RGD (Arg-Gly-Asp) Peptides is a cell adhesion motif which can mimic cell adhesion proteins and bind to integrins.
T4259 GLPG0187 GLPG0187, a broad spectrum integrin receptor antagonist, inhibits αvβ1-integrin (IC50: 1.3 nM).
T4435 E7820 E7820 is an angiogenesis inhibitor by suppressing integrin a2 (a cell adhesion molecule expressed on endothelial cells).
T4613 Arg-Gly-Asp TFA (99896-85-2(free base)) RGD Trifluoroacetate is a tripeptide that effectively triggers cell adhesion, addresses certain cell lines and elicits specific cell responses; binds to integr...
T5310 TR-14035 TR-14035 is a dual antagonist of α4β7/α4β1 integrins (IC50s: 7/87nM).
T9914 Vedolizumab Vedolizumab is a humanized monoclonal antibody that targets the α4β7 integrin for the treatment of ulcerative colitis and Crohn's disease.
T5485 OSU-T315 (1,5-regioisomer) OSU-T315 (1,5-regioisomer) is a ILK inhibitor.
T5488 OSU-T315 OSU-T315 is a novel potent, orally active ILK (integrin-linked kinase) inhibitor with IC50 of 0.6 μM.
TQ0250 CWHM-12 CWHM-12 is a potent inhibitor of αV integrins (IC50s of 0.2/0.8/1.5/1.8 nM for αvβ8/αvβ3/αvβ6/αvβ1).
TQ0291 Firategrast Firategrast is an orally bioavailable antagonist of α4β1/α4β7 integrin.
T7570 RGD peptide GRGDNP(2TFA) RGD peptide GRGDNP(2TFA) is a integrin-ligand interactions inhibitor.
T14558 BI-1950 BI-1950 is a highly potent lymphocyte function associated antigen-1 (LFA-1) inhibitor and the LFA-1 is an essential component in normal immune system function a...
T14573 Bimosiamose disodium Bimosiamose disodium has anti-inflammatory effects[1]. Bimosiamose disodium (TBC-1269Z) is a nonoligosaccharide pan-selectin inhibitor with IC50s of 88 μM, 20 ...
T14574 Bimosiamose Bimosiamose has anti-inflammatory effects[1]. Bimosiamose (TBC-1269) is a nonoligosaccharide pan-selectin antagonist with IC50s of 88 μM, 20 μM, and 86 μM fo...
T12783 RWJ 50271 RWJ 50271 is a selective lymphocyte function-associated antigen-1/intercellular adhesion molecule-1(LFA-1/ICAM-1) interaction inhibitor( IC50 of 5.0 μM in HL60...
T13147 ICAM-1-IN-1 ICAM-1-IN-1 is a potent and selective E-selectin and ICAM-1 inhibitor(IC50 of 7 and 5 nM, respectively).
T8523 ILK-IN-3 ILK-IN-3 is an inhibitor of integrin linked kinase, and with antitumor activity.
TP2148 LXW7 TFA
T13478 β-glycosidase-IN-1 β-glycosidase-IN-1 is a piperidine derivative, and is an inhibitor of β-glycosidase. It has hypoglycemic activity.
T16100 Balamapimod Balamapimod is a reversible inhibitor of Ras/Raf/MEK. It also has a potential anti-tumor activity.
T13473L αvβ1 integrin-IN-1 TFA αvβ1 integrin-IN-1 TFA is an effective and selective αvβ1 integrin inhibitor (IC50: 0.63 nM).
TP1204 iRGD peptide iRGD peptide is a 9-amino acid cyclic peptide (sequence: CRGDKGPDC) and a molecular mimicry agent that was originally identified in an in vivo screening of phag...
TP1330 Cyclo(RADfK) Cyclo(RADfK) is a selective α(v)β(3) integrin ligand that has been extensively used for research, therapy, and diagnosis of neoangiogenesis.Cyclo(RADfK) is a ...
TP1474 LXW7 LXW7 is an octamer disulfide cyclic peptide and αvβ3 integrin ligand, acts as a potent and specific endothelial progenitor cells (EPCs) and endothelial cells ...
T8726 Cyclo(RGDyK) Cyclo(RGDyK) is a potent and selective αVβ3 integrin inhibitor with IC50 of 20 nM.
Carvedilol phosphate
T0342CAS 610309-89-2
Carvedilol Phosphate is the phosphate salt form of carvedilol, a racemic mixture and adrenergic blocking agent with antihypertensive activity and devoid of intr...
Carvedilol
T0447CAS 72956-09-3
Carvedilol Phosphate is the phosphate salt form of carvedilol, a racemic mixture and adrenergic blocking agent with antihypertensive activity and devoid of intr...
A-205804
T2254CAS 251992-66-2
A-205804 is a specific and effective inhibitor of E-selectin( IC50=20 nM ) and ICAM-1(IC50=25 nM) expression.
Cilengitide
T2494CAS 188968-51-6
Cilengitide is a potent integrin inhibitor for the αvβ3/5 receptor (IC50: 4.1/79 nM, in cell-free assays); ~10-fold selectivity against gpIIbIIIa.
Tirofiban hydrochloride monohydrate
T2537CAS 150915-40-5
Tirofiban hydrochloride monohydrate is a potent non-peptide, glycoprotein IIb/IIIa (integrins alphaIIbbetaIII) antagonist.
Bestatin hydrochloride
T3529CAS 65391-42-6
Bestatin (Ubenimex) hydrochlorideis an inhibitor of aminopeptidase N (APN)/CD13 and aminopeptidase B.
Leukadherin-1
T3638CAS 344897-95-6
Leukadherin-1 is an allosteric activator of CD11b/CD18. Increasing CD11b/CD18-dependent cell adhesion to fibrinogen, Decreasing leukocyte motility and transendo...
Vaccarin
T3881CAS 53452-16-7
Vaccarin is a major flavonoid glycoside in Vaccariae semen, its biotransformation pathways involves methylation, hydroxylation, glycosylation and deglycosylatio...
Lifitegrast
T3977CAS 1025967-78-5
Lifitegrast is a lymphocyte, function-associated antigen-1 antagonist.
Tirofiban
T6182CAS 144494-65-5
Tirofiban (MK-383) is a selective palate GPIIb/IIIa antagonist which inhibits platelet aggregation with IC50 of 9 nM.
Cyclo (-RGDfK)
T6812CAS 161552-03-0
Cyclo (-RGDfK) is an effective and specific αvβ3 integrin inhibitor.
Cyclo(RGDyK)
T6813CAS 250612-42-1
Cyclo(RGDyK) is a potent and selective αVβ3 integrin inhibitor with IC50 of 20 nM.
RGD Peptides
T6966CAS 99896-85-2
RGD (Arg-Gly-Asp) Peptides is a cell adhesion motif which can mimic cell adhesion proteins and bind to integrins.
GLPG0187
T4259CAS 1320346-97-1
GLPG0187, a broad spectrum integrin receptor antagonist, inhibits αvβ1-integrin (IC50: 1.3 nM).
E7820
T4435CAS 289483-69-8
E7820 is an angiogenesis inhibitor by suppressing integrin a2 (a cell adhesion molecule expressed on endothelial cells).
Arg-Gly-Asp TFA (99896-85-2(free base))
T4613CAS T4613
RGD Trifluoroacetate is a tripeptide that effectively triggers cell adhesion, addresses certain cell lines and elicits specific cell responses; binds to integr...
TR-14035
T5310CAS 232271-19-1
TR-14035 is a dual antagonist of α4β7/α4β1 integrins (IC50s: 7/87nM).
Vedolizumab
T9914CAS 943609-66-3
Vedolizumab is a humanized monoclonal antibody that targets the α4β7 integrin for the treatment of ulcerative colitis and Crohn's disease.
OSU-T315 (1,5-regioisomer)
T5485CAS 2070015-22-2
OSU-T315 (1,5-regioisomer) is a ILK inhibitor.
OSU-T315
T5488CAS 1333146-24-9
OSU-T315 is a novel potent, orally active ILK (integrin-linked kinase) inhibitor with IC50 of 0.6 μM.
CWHM-12
TQ0250CAS 1564286-55-0
CWHM-12 is a potent inhibitor of αV integrins (IC50s of 0.2/0.8/1.5/1.8 nM for αvβ8/αvβ3/αvβ6/αvβ1).
Firategrast
TQ0291CAS 402567-16-2
Firategrast is an orally bioavailable antagonist of α4β1/α4β7 integrin.
RGD peptide GRGDNP(2TFA)
T7570CAS 114681-65-1
RGD peptide GRGDNP(2TFA) is a integrin-ligand interactions inhibitor.
BI-1950
T14558CAS 1159724-42-1
BI-1950 is a highly potent lymphocyte function associated antigen-1 (LFA-1) inhibitor and the LFA-1 is an essential component in normal immune system function a...
Bimosiamose disodium
T14573CAS 187269-60-9
Bimosiamose disodium has anti-inflammatory effects[1]. Bimosiamose disodium (TBC-1269Z) is a nonoligosaccharide pan-selectin inhibitor with IC50s of 88 μM, 20 ...
Bimosiamose
T14574CAS 187269-40-5
Bimosiamose has anti-inflammatory effects[1]. Bimosiamose (TBC-1269) is a nonoligosaccharide pan-selectin antagonist with IC50s of 88 μM, 20 μM, and 86 μM fo...
RWJ 50271
T12783CAS 162112-37-0
RWJ 50271 is a selective lymphocyte function-associated antigen-1/intercellular adhesion molecule-1(LFA-1/ICAM-1) interaction inhibitor( IC50 of 5.0 μM in HL60...
ICAM-1-IN-1
T13147CAS 251994-14-6
ICAM-1-IN-1 is a potent and selective E-selectin and ICAM-1 inhibitor(IC50 of 7 and 5 nM, respectively).
ILK-IN-3
T8523CAS 6975-75-3
ILK-IN-3 is an inhibitor of integrin linked kinase, and with antitumor activity.
LXW7 TFA
TP2148CAS NA
β-glycosidase-IN-1
T13478CAS 176485-27-1
β-glycosidase-IN-1 is a piperidine derivative, and is an inhibitor of β-glycosidase. It has hypoglycemic activity.
Balamapimod
T16100CAS 863029-99-6
Balamapimod is a reversible inhibitor of Ras/Raf/MEK. It also has a potential anti-tumor activity.
αvβ1 integrin-IN-1 TFA
T13473LCAS
αvβ1 integrin-IN-1 TFA is an effective and selective αvβ1 integrin inhibitor (IC50: 0.63 nM).
iRGD peptide
TP1204CAS 1392278-76-0
iRGD peptide is a 9-amino acid cyclic peptide (sequence: CRGDKGPDC) and a molecular mimicry agent that was originally identified in an in vivo screening of phag...
Cyclo(RADfK)
TP1330CAS 756500-23-9
Cyclo(RADfK) is a selective α(v)β(3) integrin ligand that has been extensively used for research, therapy, and diagnosis of neoangiogenesis.Cyclo(RADfK) is a ...
LXW7
TP1474CAS 1313004-77-1
LXW7 is an octamer disulfide cyclic peptide and αvβ3 integrin ligand, acts as a potent and specific endothelial progenitor cells (EPCs) and endothelial cells ...
Cyclo(RGDyK)
T8726CAS 217099-14-4
Cyclo(RGDyK) is a potent and selective αVβ3 integrin inhibitor with IC50 of 20 nM.