Integrin

Integrins are proteins that function mechanically, by attaching the cell cytoskeleton to the extracellular matrix (ECM), and biochemically, by sensing whether adhesion has occurred. The integrin family of proteins consists of alpha and beta subtypes, which form transmembrane heterodimers.

Cat. No.	Product name	CAS No.	Purity
T14574	Bimosiamose	187269-40-5	98%
T14574	Bimosiamose has anti-inflammatory effects[1]. Bimosiamose (TBC-1269) is a nonoligosaccharide pan-selectin antagonist with IC50s of 88 μM, 20 μM, and 86 μM for E-...
T6657	SB273005	205678-31-5	98%
T6657	SB273005 is a potent integrin inhibitor with Ki of 1.2 nM and 0.3 nM for αvβ3 receptor and αvβ5 receptor, respectively.
T14573	Bimosiamose disodium	187269-60-9	98%
T14573	Bimosiamose disodium has anti-inflammatory effects[1]. Bimosiamose disodium (TBC-1269Z) is a nonoligosaccharide pan-selectin inhibitor with IC50s of 88 μM, 20 μM...
T6806	Cilengitide TFA	199807-35-7	98%
T6806	Cilengitide is a potent integrin inhibitor for αvβ3 receptor and αvβ5 receptor with IC50 of 4.1 nM and 79 nM in cell-free assays, respectively; ~10-fold selectiv...
T16100	Balamapimod	863029-99-6	98%
T16100	Balamapimod is a reversible inhibitor of Ras/Raf/MEK. It also has a potential anti-tumor activity.
T13478	β-glycosidase-IN-1	176485-27-1	98%
T13478	β-glycosidase-IN-1 is a piperidine derivative, and is an inhibitor of β-glycosidase. It has hypoglycemic activity.
T9914	Vedolizumab	943609-66-3	98%
T9914	Vedolizumab is a humanized monoclonal antibody that targets the α4β7 integrin for the treatment of Crohn's disease and ulcerative colitis.
T14558	BI-1950	1159724-42-1	98%
T14558	BI-1950 is a highly potent lymphocyte function associated antigen-1 (LFA-1) inhibitor and the LFA-1 is an essential component in normal immune system function an...
TP2148	LXW7 TFA (1313004-77-1 free base)	TP2148	98%
TP2148	LXW7 TFA, a cyclic peptide containing Arg-Gly-Asp (RGD), is an integrin αvβ3 inhibitor with an anti-inflammatory effect. LXW7 has a high binding affinity to αvβ3...
T8726	Cyclo(RGDyK)	217099-14-4	98%
T8726	Cyclo(RGDyK) is a potent and selective αVβ3 integrin inhibitor with IC50 of 20 nM.
T13473L	αvβ1 integrin-IN-1 TFA (1689540-62-2 free base)	T13473L	98%
T13473L	αvβ1 integrin-IN-1 TFA is an effective and selective αvβ1 integrin inhibitor (IC50: 0.63 nM).
T21868	BIO-1211	187735-94-0	98%
T21868	BIO-1211 is a more potent inhibitor of α4β1 (VLA-4, IC50 = 4 nM) over α4β7(IC50 = 2 μM).
TP1879L1	P11 acetate	TP1879L1	98%
TP1879L1	P11 acetate is an integrin αvβ3-vitronectin interaction antagonist(IC50 = 2.74 nM).
T29089	Valategrast hydrochloride	828271-96-1	98%
T29089	Valategrast hydrochloride, a dual antagonist of integrin α4β1 (VLA-4), is used for the potential treatment of asthma.
T12177	Natalizumab	189261-10-7	98%
T12177	Natalizumab used for the treatment of relapsing remitting multiple sclerosis and Crohn's disease.
T0342	Carvedilol phosphate hemihydrate	610309-89-2	98%
T0342	Carvedilol Phosphate is the phosphate salt form of carvedilol, a racemic mixture and adrenergic blocking agent with antihypertensive activity and devoid of intri...
TP1474	LXW7	1313004-77-1	98%
TP1474	LXW7 is an octamer disulfide cyclic peptide and αvβ3 integrin ligand, acts as a potent and specific endothelial progenitor cells (EPCs) and endothelial cells (EC...
TP1330	Cyclo(RADfK)	756500-23-9	98%
TP1330	Cyclo(RADfK) is a selective α(v)β(3) integrin ligand that has been extensively used for research, therapy, and diagnosis of neoangiogenesis.Cyclo(RADfK) is a neg...
T7570	RGD peptide (GRGDNP)	114681-65-1	98%
T7570	RGD peptide GRGDNP(2TFA) is a integrin-ligand interactions inhibitor.
T23796	BIRT-377	213211-10-0	98%
T23796	BIRT-377 is a negative allosteric and orally bioavailable inhibitor of ICAM-1 and LFA-1(Ki = 25.8 nM). BIRT-377 inhibits the production of IL-2 and can be used i...