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Valategrast hydrochloride
😃Good
Catalog No. T29089Cas No. 828271-96-1
Alias Valategrast HCl, RO-27-2441, RO27244, RO-0272441, RO0272441, R-411, R411
Valategrast hydrochloride (R411), a dual antagonist of integrin α4β1 (VLA-4), is used for the potential treatment of asthma.
Valategrast hydrochloride
😃Good
Catalog No. T29089Alias Valategrast HCl, RO-27-2441, RO27244, RO-0272441, RO0272441, R-411, R411Cas No. 828271-96-1
Valategrast hydrochloride (R411), a dual antagonist of integrin α4β1 (VLA-4), is used for the potential treatment of asthma.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $1,670 | 6-8 weeks | |
| 50 mg | $2,180 | 6-8 weeks | |
| 100 mg | $2,800 | 6-8 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Valategrast hydrochloride (R411), a dual antagonist of integrin α4β1 (VLA-4), is used for the potential treatment of asthma. |
| In vitro | Valategrast hydrochloride incorporates a prevalent l-phenylalanine-N-aroyl structure, with the carboxylic acid moiety facilitating attachment to the metal ion at the metal-ion-dependent adhesion site (MIDAS)[2]. |
| Alias | Valategrast HCl, RO-27-2441, RO27244, RO-0272441, RO0272441, R-411, R411 |
| Molecular Weight | 641.41 |
| Formula | C30H33Cl4N3O4 |
| Cas No. | 828271-96-1 |
| Smiles | C(N[C@@H](CC1=CC=C(NC(=O)C2=C(Cl)C=CC=C2Cl)C=C1)C(OCCN(CC)CC)=O)(=O)C3=C(C)C=CC=C3Cl.Cl |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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