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ICAM-1-IN-1
🥰Excellent
Catalog No. T13147Cas No. 251994-14-6
ICAM-1-IN-1 is a potent and selective inhibitor of E-selectin (IC50 = 7 nM) and ICAM-1 (IC50 = 5 nM).
ICAM-1-IN-1
🥰Excellent
Purity: 99.34%
Catalog No. T13147Cas No. 251994-14-6
ICAM-1-IN-1 is a potent and selective inhibitor of E-selectin (IC50 = 7 nM) and ICAM-1 (IC50 = 5 nM).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $195 | In Stock | |
| 5 mg | $413 | In Stock | |
| 10 mg | $618 | In Stock | |
| 25 mg | $985 | In Stock | |
| 50 mg | $1,330 | In Stock | |
| 100 mg | $1,790 | In Stock | |
| 500 mg | $3,590 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $455 | In Stock |
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Purity:99.34%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | ICAM-1-IN-1 is a potent and selective inhibitor of E-selectin (IC50 = 7 nM) and ICAM-1 (IC50 = 5 nM). |
| Targets&IC50 | Eselectin:7 nM , ICAM1:5 nM |
| In vivo | In both a rat model of rheumatoid arthritis and a mouse model of asthma, ICAM-1-IN-1 demonstrates significant therapeutic effects. Notably, after nine days of treatment with ICAM-1-IN-1, there is a reduction in the swelling of inflamed ankles in the rat arthritis model; however, it does not exhibit efficacy during the acute phase of the condition. A 21-day regimen of ICAM-1-IN-1 at a dosage of 25 mg/kg markedly decreases ankle inflammation in arthritic rats. Additionally, this treatment leads to a notable decrease in eosinophil counts and levels of serum-soluble ICAM-1 (sICAM-1). |
| Molecular Weight | 363.23 |
| Formula | C15H11BrN2O2S |
| Cas No. | 251994-14-6 |
| Smiles | CNC(=O)c1cc2c(Oc3ccc(Br)cc3)cncc2s1 |
| Relative Density. | 1.556 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 50 mg/mL (137.65 mM)  | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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