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Lifitegrast
🥰Excellent
Catalog No. T3977Cas No. 1025967-78-5
Alias SHP-606, SAR 1118
Lifitegrast (SAR 1118) is an antagonist of lymphocyte function-associated antigen-1.
Lifitegrast
🥰Excellent
Purity: 99.66%
Catalog No. T3977Alias SHP-606, SAR 1118Cas No. 1025967-78-5
Lifitegrast (SAR 1118) is an antagonist of lymphocyte function-associated antigen-1.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $33 | In Stock | |
| 10 mg | $52 | In Stock | |
| 25 mg | $93 | In Stock | |
| 50 mg | $147 | In Stock | |
| 100 mg | $239 | In Stock | |
| 500 mg | $588 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $55 | In Stock |
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Purity:99.66%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Lifitegrast (SAR 1118) is an antagonist of lymphocyte function-associated antigen-1. |
| Targets&IC50 | LFA1:2.98 nM. |
| In vitro | Lifitegrast is a novel small molecule integrin antagonist that inhibits T cell-mediated inflammation by blocking the binding of two important cell surface proteins (lymphocyte function-associated antigen 1 and intercellular adhesion molecule 1), thus lessening overall inflammatory responses. Lifitegrast strongly inhibits Jurkat T cell attachment to ICAM-1 with an IC50 of 2.98 nM[1]. |
| In vivo | Lifitegrast, has potent anti-inflammatory activity on corneal inflammation induced by antibiotic-killed P. aeruginosa and S. aureus in the presence of a silicone hydrogel lens with the optimal application being a 1% solution applied either 2 or 3 times prior. Topical application of lifitegrast to the corneal surface of healthy adults is safe and well tolerated[2]. SAR 1118 ophthalmic drops administered thrice daily deliver therapeutic levels of SAR 1118 in the retina and can alleviate the retinal complications associated with diabetes[3]. |
| Alias | SHP-606, SAR 1118 |
| Molecular Weight | 615.48 |
| Formula | C29H24Cl2N2O7S |
| Cas No. | 1025967-78-5 |
| Smiles | CS(=O)(=O)c1cccc(C[C@H](NC(=O)c2c(Cl)cc3CN(CCc3c2Cl)C(=O)c2ccc3ccoc3c2)C(O)=O)c1 |
| Relative Density. | no data available |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 50 mg/mL (81.24 mM)  | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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