Shopping Cart
- Remove All
Your shopping cart is currently empty
BIO-1211
Catalog No. T21868Cas No. 187735-94-0
BIO-1211 is a more potent inhibitor of α4β1 (VLA-4, IC50 = 4 nM) over α4β7(IC50 = 2 μM).
BIO-1211
Catalog No. T21868Cas No. 187735-94-0
BIO-1211 is a more potent inhibitor of α4β1 (VLA-4, IC50 = 4 nM) over α4β7(IC50 = 2 μM).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $113 | In Stock | |
| 2 mg | $168 | In Stock | |
| 5 mg | $289 | In Stock | |
| 10 mg | $463 | In Stock | |
| 25 mg | $748 | In Stock | |
| 50 mg | $987 | In Stock | |
| 100 mg | $1,380 | In Stock |
Bulk & Custom
Add to Cart
Questions
View MoreInhibitors Related to "BIO-1211"
Tirofiban hydrochloride monohydrate
Tirofiban Hydrochloride, MK-383 Hydrochloride
T2537150915-40-5
Tirofiban（MK383） hydrochloride monohydrate is a non-peptide glycoprotein IIb/IIIa antagonist.
- $40
Size
QTY
Bestatin hydrochloride
Cited
Ubenimex hydrochloride
T352965391-42-6
Bestatin hydrochloride (Ubenimex hydrochloride) is an inhibitor of aminopeptidase N (APN)/CD13 and aminopeptidase B.
- $47
Size
QTY
CitedLifitegrast
SHP-606, SAR 1118
T39771025967-78-5
Lifitegrast (SAR 1118) is an antagonist of lymphocyte function-associated antigen-1.
- $33
Size
QTY
K34c hydrochloride
K34c hydrochloride(939769-93-4 Free base)
T41151LIn house
K34c hydrochloride is an alpha5β1 integrin antagonist for glioblastoma study.
- $350
Size
QTY
ICAM-1-IN-1
T13147251994-14-6In house
ICAM-1-IN-1 is a potent and selective inhibitor of E-selectin (IC50 = 7 nM) and ICAM-1 (IC50 = 5 nM).
- $195
Size
QTY
E7820
ER68203-00
T4435289483-69-8
E7820 (ER68203-00) is an angiogenesis inhibitor by suppressing integrin a2 (a cell adhesion molecule expressed on endothelial cells).
- $30
Size
QTY
Gantofiban
T68078183547-57-1In house
Gantofiban is a glycoprotein IIb/IIIa (GP IIb/IIIa) antagonist used in the treatment of cardiovascular disease and may be used to study thrombosis.
- $191
Size
QTY
Elarofiban TFA
RWJ-53308 TFA, Elarofiban TFA（198958-88-2 Free base）
T27250L198958-89-3In house
Elarofiban TFA (RWJ-53308 TFA) is a novel and orally active and selective GPIIb/IIIa antagonist for the study of cardiovascular disease.
- $195
Size
QTY
Cyclo(-RGDfK)
Cyclo (-RGDfK)
T6812161552-03-0
Cyclo(-RGDfK) is a potent and selective inhibitor of integrin αvβ3 with IC50 of 0.94 nM. Cyclo specifically targets tumor microvasculature and cancer cells by binding to αvβ3 integrin on the cell surface.
- $40
Size
QTY
Select Batch
Purity:99.33%
Contact us for more batch information
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | BIO-1211 is a more potent inhibitor of α4β1 (VLA-4, IC50 = 4 nM) over α4β7(IC50 = 2 μM). |
| Targets&IC50 | α4β7:2 μM, α4β1:4 nM |
| In vitro | BIO-1211 does not show activity against α1β1, α5β1, α6β1, αLβ2 and αIIbβ3[2]. |
| In vivo | In naive, C57BL/6 mice, BIO-1211 exhibited a considerable depletion in the EAE clinical score, which correlated with decreased expression of TNF-α, IL-17, IFN-γ and pervade of CD11b+ and CD45+ cells into the cerebral cortex. BIO-1211 resulted in reduced cytokines expression, leukocyte trafficking, and inhibition of inflammatory responses in a dose-independent manner[1]. |
| Molecular Weight | 708.8 |
| Formula | C36H48N6O9 |
| Cas No. | 187735-94-0 |
Storage & Solubility Information
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 250 mg/mL (352.71 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
| ||||||||||||||||||||||||||||||||||||
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Preview
Related Tags: buy BIO-1211 | purchase BIO-1211 | BIO-1211 cost | order BIO-1211 | BIO-1211 chemical structure | BIO-1211 in vivo | BIO-1211 in vitro | BIO-1211 formula | BIO-1211 molecular weight
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2024 TargetMol Chemicals Inc. All Rights Reserved.