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Cyclo(RGDfC) TFA
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Catalog No. T76068
Alias Cyclo(Arg-Gly-Asp-D-Phe-Cys) TFA
Cyclo(RGDfC) TFA (Cyclo(Arg-Gly-Asp-D-Phe-Cys) TFA) is a cyclic pentapeptide, a cyclic RGD polypeptide with high affinity for αvβ3, which is capable of disrupting cellular integrin interactions. Cyclo(RGDfC) TFA inhibits pluripotent gene expression in embryonic stem cells (ESCs) and inhibits tumorigenic potential of mESCs in vivo. Cyclo(RGDfC) TFA inhibits the tumorigenic potential of mESC. Cyclo(RGDfC) TFA can be used for tumor-related studies.
Cyclo(RGDfC) TFA
😃Good
Purity: 98.59%
Catalog No. T76068Alias Cyclo(Arg-Gly-Asp-D-Phe-Cys) TFA
Cyclo(RGDfC) TFA (Cyclo(Arg-Gly-Asp-D-Phe-Cys) TFA) is a cyclic pentapeptide, a cyclic RGD polypeptide with high affinity for αvβ3, which is capable of disrupting cellular integrin interactions. Cyclo(RGDfC) TFA inhibits pluripotent gene expression in embryonic stem cells (ESCs) and inhibits tumorigenic potential of mESCs in vivo. Cyclo(RGDfC) TFA inhibits the tumorigenic potential of mESC. Cyclo(RGDfC) TFA can be used for tumor-related studies.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $38 | Backorder | |
| 5 mg | Inquiry | In Stock |
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CitedSelect Batch
Purity:98.59%
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Product Introduction
Bioactivity
Chemical Properties
| Description | Cyclo(RGDfC) TFA (Cyclo(Arg-Gly-Asp-D-Phe-Cys) TFA) is a cyclic pentapeptide, a cyclic RGD polypeptide with high affinity for αvβ3, which is capable of disrupting cellular integrin interactions. Cyclo(RGDfC) TFA inhibits pluripotent gene expression in embryonic stem cells (ESCs) and inhibits tumorigenic potential of mESCs in vivo. Cyclo(RGDfC) TFA inhibits the tumorigenic potential of mESC. Cyclo(RGDfC) TFA can be used for tumor-related studies. |
| In vitro | 0.5 mM Cyclo(RGDfC) TFA, treated for 24 h was able to down-regulate the expression of the transcription factors Oct 4, Sox 2, and Nanog in mESC and inhibit the expression of integrin genes in the mESC-col I (collagen type I) construct. In addition, treated mESC cells formed agglomerates and detached from the surface. [1] |
| In vivo | 0.5 mM Cyclo(RGDfC) TFA, treated for 24 h. Treated mESC in the presence or absence of leukemia inhibitory factor (LIF) (by double leg injection) inhibited teratoma formation in severe combined immunodeficiency (SCID) mice. [1] |
| Alias | Cyclo(Arg-Gly-Asp-D-Phe-Cys) TFA |
| Molecular Weight | 692.67 |
| Formula | C26H35F3N8O9S |
| Smiles | O=C([C@@H](NC(CNC([C@@H](NC([C@@H](NC1=O)CS)=O)CCCNC(N)=N)=O)=O)CC(O)=O)N[C@@H]1CC2=CC=CC=C2.OC(C(F)(F)F)=O |
Storage & Solubility Information
| Storage | keep away from moisture,keep away from direct sunlight,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||
| Solubility Information | H2O: 10 mg/mL (14.44 mM), Sonication is recommended. | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
H2O
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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