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Carotegrast methyl

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Purity:98.73%

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COA HPLC HNMR

Carotegrast methyl

Catalog No. T30751Cas No. 401905-67-7

Carotegrast methyl (AJM300), an orally-active small molecule, can antagonize the α4 integrin receptor. It is a specific and dual α4β1/α4β7 integrin antagonist.

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Pack Size	Price	Availability
1 mg	$77	In Stock
5 mg	$189	In Stock
10 mg	$313	In Stock
25 mg	$622	In Stock
50 mg	$955	In Stock
100 mg	$1,390	In Stock
1 mL x 10 mM (in DMSO)	$226	In Stock

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Product Introduction

Bioactivity

Description	Carotegrast methyl (AJM300), an orally-active small molecule, can antagonize the α4 integrin receptor. It is a specific and dual α4β1/α4β7 integrin antagonist.
Alias	AJM300

Chemical Properties

Molecular Weight	569.44
Formula	C28H26Cl2N4O5
Cas No.	401905-67-7

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 100 mg/mL (175.61 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7561 mL	8.7806 mL	17.5611 mL	87.8056 mL
5 mM	0.3512 mL	1.7561 mL	3.5122 mL	17.5611 mL
10 mM	0.1756 mL	0.8781 mL	1.7561 mL	8.7806 mL
20 mM	0.0878 mL	0.4390 mL	0.8781 mL	4.3903 mL
50 mM	0.0351 mL	0.1756 mL	0.3512 mL	1.7561 mL
100 mM	0.0176 mL	0.0878 mL	0.1756 mL	0.8781 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

Dose Conversion

You can also refer to dose conversion for different animals. More

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc