Shopping Cart
- Remove All
Your shopping cart is currently empty
Arg-Gly-Asp-Ser
🥰Excellent
Catalog No. T10366Cas No. 91037-65-9
Alias RGDS peptide, Fibronectin tetrapeptide
Arg-Gly-Asp-Ser (RGDS peptide) is a conserved tetrapeptide sequence found on fibronectin, fibrinogen α, and von Willebrand factor. It binds to integrins on the cell surface, inhibiting thrombin-induced platelet-fibrinogen interaction.
Arg-Gly-Asp-Ser
🥰Excellent
Catalog No. T10366Alias RGDS peptide, Fibronectin tetrapeptideCas No. 91037-65-9
Arg-Gly-Asp-Ser (RGDS peptide) is a conserved tetrapeptide sequence found on fibronectin, fibrinogen α, and von Willebrand factor. It binds to integrins on the cell surface, inhibiting thrombin-induced platelet-fibrinogen interaction.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $31 | In Stock | |
| 10 mg | $51 | In Stock | |
| 25 mg | $94 | In Stock | |
| 50 mg | $137 | In Stock | |
| 100 mg | $197 | In Stock |
Bulk & Custom
Add to Cart
Questions
View MoreInhibitors Related to "Arg-Gly-Asp-Ser"
Cilengitide
Cited
EMD 121974
T2494188968-51-6
Cilengitide (EMD 121974) is a potent integrin inhibitor for the αvβ3/5 receptor (IC50: 4.1/79 nM, in cell-free assays) with approximately 10-fold selectivity against gpIIbIIIa.
- $45
Size
QTY
CitedArg-Gly-Asp TFA (99896-85-2(free base)) Cited
RGD Trifluoroacetate, RGD
T4613
Arg-Gly-Asp TFA (99896-85-2(free base)) (RGD Trifluoroacetate) is a tripeptide that effectively triggers cell adhesion, addresses certain cell lines and elicits specific cell responses; binds to integrins.
- $35
Size
QTY
CitedLifitegrast
SHP-606, SAR 1118
T39771025967-78-5
Lifitegrast (SAR 1118) is an antagonist of lymphocyte function-associated antigen-1.
- $33
Size
QTY
Elarofiban TFA
RWJ-53308 TFA, Elarofiban TFA(198958-88-2 Free base)
T27250L198958-89-3In house
Elarofiban TFA (RWJ-53308 TFA) is a novel and orally active and selective GPIIb/IIIa antagonist for the study of cardiovascular disease.
- $195
Size
QTY
E7820
ER68203-00
T4435289483-69-8
E7820 (ER68203-00) is an angiogenesis inhibitor by suppressing integrin a2 (a cell adhesion molecule expressed on endothelial cells).
- $30
Size
QTY
RO0270608
T36716220846-33-3In house
RO0270608, the active metabolite of R411, is an orally active dual α4β1/α4β7 integrin antagonist with anti-inflammatory properties, useful for studying allergic inflammatory responses.
- $117
Size
QTY
Bestatin hydrochloride Cited
Ubenimex hydrochloride
T352965391-42-6
Bestatin hydrochloride (Ubenimex hydrochloride) is an inhibitor of aminopeptidase N (APN)/CD13 and aminopeptidase B.
- $47
Size
QTY
CitedK34c hydrochloride
K34c hydrochloride(939769-93-4 Free base)
T41151LIn house
K34c hydrochloride is an alpha5β1 integrin antagonist for glioblastoma study.
- $350
Size
QTY
ICAM-1-IN-1
T13147251994-14-6In house
ICAM-1-IN-1 is a potent and selective inhibitor of E-selectin (IC50 = 7 nM) and ICAM-1 (IC50 = 5 nM).
- $195
Size
QTY
Tirofiban hydrochloride monohydrate
Tirofiban Hydrochloride monohydrate, MK-383 Hydrochloride monohydrate
T2537150915-40-5
Tirofiban(MK383) hydrochloride monohydrate is a non-peptide glycoprotein IIb/IIIa antagonist.
- $40
Size
QTY
Gantofiban
T68078183547-57-1In house
Gantofiban is a glycoprotein IIb/IIIa (GP IIb/IIIa) antagonist used in the treatment of cardiovascular disease and may be used to study thrombosis.
- $191
Size
QTY
Cyclo(-RGDfK)
Cyclo (-RGDfK)
T6812161552-03-0
Cyclo(-RGDfK) is a potent and selective inhibitor of integrin αvβ3 with IC50 of 0.94 nM. Cyclo specifically targets tumor microvasculature and cancer cells by binding to αvβ3 integrin on the cell surface.
- $40
Size
QTY
Contact us for more batch information
Resource Download
Product Introduction
Bioactivity
Chemical Properties
| Description | Arg-Gly-Asp-Ser (RGDS peptide) is a conserved tetrapeptide sequence found on fibronectin, fibrinogen α, and von Willebrand factor. It binds to integrins on the cell surface, inhibiting thrombin-induced platelet-fibrinogen interaction. |
| In vitro | Arg-Gly-Asp-Ser increases mRNA expression and secretion of TGF-β1 by stimulating the promoter of TGF-β1 gene. [1] Cell binding to RGDS eliminates apoptosis through the mitochondrial pathway, and inhibition of apoptosis depends on the activity of phosphatidylinositol 3-kinase. [2] |
| In vivo | Arg-Gly-Asp-Ser (1, 2.5, or 5 mg/kg, intraperitoneally administered) inhibited LPS-induced increases in the number of neutrophils and macrophages, total protein levels, TNF-α and MIP-2 levels, and matrix metalloproteinase-9 activity in mouse bronchoalveolar lavage fluid (BAL). [3] Arg-Gly-Asp-Ser almost completely inhibited lung colonization of intravenous PAK 17.15 cells in C57BL/6 mice. [4] |
| Alias | RGDS peptide, Fibronectin tetrapeptide |
| Molecular Weight | 433.42 |
| Formula | C15H27N7O8 |
| Cas No. | 91037-65-9 |
| Smiles | [C@H](C(N[C@H](C(O)=O)CO)=O)(NC(CNC([C@H](CCCNC(=N)N)N)=O)=O)CC(O)=O |
| Relative Density. | 1.65g/cm3 |
Storage & Solubility Information
| Storage | keep away from moisture,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 40 mg/mL (92.29 mM), Sonication is recommended. H2O: 25 mg/mL (57.68 mM) | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
H2O/DMSO
| |||||||||||||||||||||||||||||||
Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
Preview
Related Tags: buy Arg-Gly-Asp-Ser | purchase Arg-Gly-Asp-Ser | Arg-Gly-Asp-Ser cost | order Arg-Gly-Asp-Ser | Arg-Gly-Asp-Ser chemical structure | Arg-Gly-Asp-Ser in vivo | Arg-Gly-Asp-Ser in vitro | Arg-Gly-Asp-Ser formula | Arg-Gly-Asp-Ser molecular weight
- TOP
Feedback
Hello! How can I help you today? 
Copyright © 2015-2024 TargetMol Chemicals Inc. All Rights Reserved.