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Bimosiamose

Catalog No. T14574Cas No. 187269-40-5

Bimosiamose has anti-inflammatory effects[1]. Bimosiamose (TBC-1269) is a nonoligosaccharide pan-selectin antagonist with IC50s of 88 μM, 20 μM, and 86 μM for E-selectin, L-selectin, and P-selectin respectively.

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Pack Size	Price	Availability	Quantity
1 mg	$213	35 days
5 mg	$778	35 days

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Product Introduction

Bioactivity

Description	Bimosiamose has anti-inflammatory effects[1]. Bimosiamose (TBC-1269) is a nonoligosaccharide pan-selectin antagonist with IC50s of 88 μM, 20 μM, and 86 μM for E-selectin, L-selectin, and P-selectin respectively.
In vitro	Bimosiamose (TBC-1269) effectively inhibits neutrophil recruitment to inflammation sites by obstructing the initial rolling phase of recruitment, without exhibiting cytotoxic effects on neutrophils.
In vivo	Bimosiamose (TBC-1269; 25 mg/kg; intravenous injection; Sprague-Dawley rats) treatment shows a significant increase in survival. Neutrophil migration is also significantly ameliorated (81%). The histologic damage scores is also improved[1]. Best overall survival, 70%, is observed when TBC-1269 is administered 15 minutes before reperfusion. It also shows a marked decrease in liver enzyme levels at 6 hours after reperfusion.
Alias	TBC-1269

Chemical Properties

Molecular Weight	862.91
Formula	C46H54O16
Cas No.	187269-40-5

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

0.1 M NaOH: 25 mg/mL (28.97 mM)

DMSO: 125 mg/mL (144.86 mM)

Solution Preparation Table

DMSO/0.1 M NaOH

	1mg	5mg	10mg	50mg
1 mM	1.1589 mL	5.7943 mL	11.5887 mL	57.9435 mL
5 mM	0.2318 mL	1.1589 mL	2.3177 mL	11.5887 mL
10 mM	0.1159 mL	0.5794 mL	1.1589 mL	5.7943 mL
20 mM	0.0579 mL	0.2897 mL	0.5794 mL	2.8972 mL

DMSO

	1mg	5mg	10mg	50mg
50 mM	0.0232 mL	0.1159 mL	0.2318 mL	1.1589 mL
100 mM	0.0116 mL	0.0579 mL	0.1159 mL	0.5794 mL

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10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL.

Mother liquor preparation method: 2 mg of drug dissolved in 50 μLDMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μLDMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μLTween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify.

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