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Bimosiamose
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Catalog No. T14574Cas No. 187269-40-5
Alias TBC-1269
Bimosiamose has anti-inflammatory effects[1]. Bimosiamose (TBC-1269) is a nonoligosaccharide pan-selectin antagonist with IC50s of 88 μM, 20 μM, and 86 μM for E-selectin, L-selectin, and P-selectin respectively.
Bimosiamose
😃Good
Catalog No. T14574Alias TBC-1269Cas No. 187269-40-5
Bimosiamose has anti-inflammatory effects[1]. Bimosiamose (TBC-1269) is a nonoligosaccharide pan-selectin antagonist with IC50s of 88 μM, 20 μM, and 86 μM for E-selectin, L-selectin, and P-selectin respectively.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $213 | 35 days | |
| 5 mg | $778 | 35 days |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Bimosiamose has anti-inflammatory effects[1]. Bimosiamose (TBC-1269) is a nonoligosaccharide pan-selectin antagonist with IC50s of 88 μM, 20 μM, and 86 μM for E-selectin, L-selectin, and P-selectin respectively. |
| Targets&IC50 | L-selectin:86 μM, P-selectin:20 μM, Eselectin:88 μM |
| In vitro | Bimosiamose (TBC-1269) effectively inhibits neutrophil recruitment to inflammation sites by obstructing the initial rolling phase of recruitment, without exhibiting cytotoxic effects on neutrophils. |
| In vivo | Bimosiamose (TBC-1269; 25 mg/kg; intravenous injection; Sprague-Dawley rats) treatment significantly increases survival, ameliorates neutrophil migration by 81%, and improves histologic damage scores[1]. The best overall survival rate of 70% is observed when administered 15 minutes before reperfusion, with a marked decrease in liver enzyme levels at 6 hours after reperfusion. |
| Alias | TBC-1269 |
| Molecular Weight | 862.91 |
| Formula | C46H54O16 |
| Cas No. | 187269-40-5 |
| Relative Density. | 1.417 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||||||||||||
| Solubility Information | 0.1 M NaOH: 25 mg/mL (28.97 mM), when pH is adjusted to 10 with NaOH. Sonication is recommended. DMSO: 125 mg/mL (144.86 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||||||||||||
0.1 M NaOH/DMSO
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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