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Cyclo(RGDyK) trifluoroacetate

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Purity:98%

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COA HNMR

Cyclo(RGDyK) trifluoroacetate

Catalog No. T6813Cas No. 250612-42-1

Cyclo(RGDyK) trifluoroacetate is a potent and selective αVβ3 integrin inhibitor with IC50 of 20 nM.

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Pack Size	Price	Availability
1 mg	$38	In Stock
5 mg	$89	In Stock
10 mg	$147	In Stock
25 mg	$297	In Stock
50 mg	$488	In Stock
100 mg	$712	In Stock
1 mL x 10 mM (in DMSO)	$137	In Stock

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Product Introduction

Bioactivity

Description	Cyclo(RGDyK) trifluoroacetate is a potent and selective αVβ3 integrin inhibitor with IC50 of 20 nM.
In vitro	Cyclo(RGDyK) shows high affinity and selectivity for αVβ3 over αVβ5 and αIIbβ3. [1] Cyclo(RGDyK)-conjugated micelles (TPM) facilitated the cell-specific uptake of DiI into B16-F10 cells and HUVECs via integrin-mediated endocytosis compared with Cyclo(RGDyK) -free micelles (NPM). [2]
In vivo	In apoE?/? mice, Cyclo(RGDyK) (1 nmol, i.v.) inhibits the increase of αVβ3 integrin expression in the intima of the left stenotic carotid artery. [2]
Alias	Cyclo(RGDyK)

Chemical Properties

Molecular Weight	847.72
Formula	C31H43F6N9O12
Cas No.	250612-42-1

Storage & Solubility Information

Storage

keep away from moisture Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 130 mg/mL(153.35 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.1796 mL	5.8982 mL	11.7963 mL	58.9817 mL
5 mM	0.2359 mL	1.1796 mL	2.3593 mL	11.7963 mL
10 mM	0.1180 mL	0.5898 mL	1.1796 mL	5.8982 mL
20 mM	0.0590 mL	0.2949 mL	0.5898 mL	2.9491 mL
50 mM	0.0236 mL	0.1180 mL	0.2359 mL	1.1796 mL
100 mM	0.0118 mL	0.0590 mL	0.1180 mL	0.5898 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc