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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $259 | In Stock | |
5 mg | $635 | In Stock | |
10 mg | $859 | In Stock | |
25 mg | $1,520 | In Stock | |
50 mg | $1,980 | In Stock | |
100 mg | $2,500 | In Stock | |
1 mL x 10 mM (in DMSO) | $749 | In Stock |
Description | BMS-688521 BMS-688521 is an orally active and potent inhibitor of LFA-1/ICAM interaction, a small molecule antagonist of leukocyte function-associated antigen-1 (LFA-1), with potential anti-inflammatory activity. |
In vitro | BMS-688521 inhibits the specific adhesion of mouse splenocytes and a mouse ICAM-1 expressing cell line, b.END3, with an IC50 of 78 nM[1]. |
In vivo | In BALB/c female mice, 6-8 weeks of age (OVA Lung Inflammation in Mice), BMS-688521 (1, 3, and 10 mg/kg; p.o.; BID for three days) exhibited significant inhibition of eosinophil accumulation at a dose of 1 mg/kg BID, with dose-dependent inhibition observed at 3 mg/kg and 10 mg/kg[1]. |
Molecular Weight | 536.37 |
Formula | C26H19Cl2N5O4 |
Cas No. | 893397-44-9 |
Storage | store at low temperature,keep away from direct sunlight Powder: -20°C for 3 years | In solvent: -80°C for 1 year | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 80 mg/mL (149.15 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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