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BMS-688521 BMS-688521 is an orally active and potent inhibitor of LFA-1/ICAM interaction, a small molecule antagonist of leukocyte function-associated antigen-1 (LFA-1), with potential anti-inflammatory activity.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $193 | In Stock | |
5 mg | $488 | In Stock | |
10 mg | $689 | In Stock | |
25 mg | $1,230 | In Stock | |
50 mg | $1,620 | In Stock | |
100 mg | $1,980 | In Stock | |
1 mL x 10 mM (in DMSO) | $576 | In Stock |
Description | BMS-688521 BMS-688521 is an orally active and potent inhibitor of LFA-1/ICAM interaction, a small molecule antagonist of leukocyte function-associated antigen-1 (LFA-1), with potential anti-inflammatory activity. |
Targets&IC50 | ICAM1:78 nM |
In vitro | BMS-688521 inhibits the specific adhesion of mouse splenocytes and a mouse ICAM-1 expressing cell line, b.END3, with an IC50 of 78 nM[1]. |
In vivo | In BALB/c female mice, 6-8 weeks of age (OVA Lung Inflammation in Mice), BMS-688521 (1, 3, and 10 mg/kg; p.o.; BID for three days) exhibited significant inhibition of eosinophil accumulation at a dose of 1 mg/kg BID, with dose-dependent inhibition observed at 3 mg/kg and 10 mg/kg[1]. |
Molecular Weight | 536.37 |
Formula | C26H19Cl2N5O4 |
Cas No. | 893397-44-9 |
Smiles | O=C1[C@@]2([C@@H](CN(C2)C3=CC=C(C(O)=O)C=N3)C4=CC=C(C#N)C=C4)N(C)C(=O)N1C5=CC(Cl)=CC(Cl)=C5 |
Relative Density. | 1.60 g/cm3 (Predicted) |
Storage | store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 80 mg/mL (149.15 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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