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Cysteamine hydrochloride

Catalog No. T6460 CAS 156-57-0

Synonyms: 2-Mercaptoethylamine Hydrochloride, β-Mercaptoethylamine Hydrochloride, Thioethanolamine Hydrochloride, 2-Aminoethanethiol Hydrochloride, Cysteamine HCl, Bekaptan

Cysteamine hydrochloride (Thioethanolamine Hydrochloride) is an agent for the treatment of nephropathic cystinosis and an antioxidant.

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Cysteamine hydrochloride Chemical Structure

Cysteamine hydrochloride, CAS 156-57-0

Pack Size	Availability	Price/USD
500 mg	In stock	$ 42.00
5 g	In stock	$ 50.00
1 mL * 10 mM (in DMSO)	In stock	$ 46.00

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Purity: 95%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Cysteamine hydrochloride (Thioethanolamine Hydrochloride) is an agent for the treatment of nephropathic cystinosis and an antioxidant.
In vitro	Cysteamine enhances intracellular glutathione (GSH) levels in cystinotic cells, effectively restoring their altered redox state and demonstrating antioxidant capabilities by increasing glutathione production, thus scavenging harmful OH and HOCl. It also mitigates increased apoptosis rates in cystinotic cells by counteracting the effects of elevated caspase 3 and protein kinase Cε activity. Furthermore, Cysteamine boosts the production of various heat shock proteins (HSP), notably murine Hsp40. It exhibits a dose-dependent mitigation of doxorubicin-induced death in cancer cells, including HeLa and B16 cells, without affecting cell survival on its own. Remarkably, it enhances the efficacy of doxorubicin in doxorubicin-resistant breast cancer cells, significantly increasing cell death. Additionally, Cysteamine (100 μM) not only heightens intracellular GSH levels but also improves the development of matured oocytes to the blastocyst stage in embryo cultures. [1][2]
In vivo	Cysteamine is introduced as a treatment for cystinosis by depleting lysosomal cystine. Cystamine can inhibit transglutaminase activity by binding to the cysteine in its active center. Cysteamine increases brain levels of brain-derived neurotrophic factor (BDNF), which is caused by the increased expression of the heat shock DNAJ-containing protein 1 (HSJ1). Cysteamine inhibits the formation of gastric and mammary tumors that are induced chemically or after irradiation, respectively. The administration of Cysteamine is also able to inhibit the metastasis of pancreatic cancer in a mouse model by decreasing the expression and activity of metalloproteinases. [1]

Synonyms	2-Mercaptoethylamine Hydrochloride, β-Mercaptoethylamine Hydrochloride, Thioethanolamine Hydrochloride, 2-Aminoethanethiol Hydrochloride, Cysteamine HCl, Bekaptan
Molecular Weight	113.61
Formula	C2H7NS·HCl
CAS No.	156-57-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: 22 mg/mL (193.6 mM)

H2O: 21 mg/mL (184.8 mM)

DMSO: 22 mg/mL (193.6 mM)

References and Literature

1. Besouw M, et al. Drug Discov Today, 2013, 18(15-16), 785-792. 2. de Matos DG, et al. Mol Reprod Dev, 1995, 42(4), 432-436.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Approved Drug Library Anti-Cancer Drug Library Human Endogenous Metabolite Library Drug Repurposing Compound Library Anti-Cancer Compound Library Bioactive Compound Library Anti-Aging Compound Library Anti-Fibrosis Compound Library RO5 Drug-like Natural Product Library Anti-Obesity Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Keywords

Cysteamine hydrochloride 156-57-0 Apoptosis Autophagy Immunology/Inflammation Metabolism NF-Κb Others Reactive Oxygen Species Endogenous Metabolite cystinosis b-Mercaptoethylamine Hydrochloride antioxidant 2-Aminoethanethiol nephropathic 2-Mercaptoethylamine Hydrochloride Inhibitor Cysteamine β-Mercaptoethylamine Hydrochloride Thioethanolamine Hydrochloride 2-Aminoethanethiol Hydrochloride inhibit Cysteamine Hydrochloride beta-Mercaptoethylamine Hydrochloride orally 2-Mercaptoethylamine Cysteamine HCl Bekaptan inhibitor

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