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Darunavir

Catalog No. T2324 CAS 206361-99-1

Synonyms: TMC114

Darunavir is an HIV Protease INHIBITOR that is used in the treatment of AIDS and HIV INFECTIONS. Due to the emergence of Antiviral DRUG RESISTANCE when used alone, it is administered in combination with other ANTI-HIV AGENTS.

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Darunavir, CAS 206361-99-1

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description

Darunavir is an HIV PROTEASE INHIBITOR that is used in the treatment of AIDS and HIV INFECTIONS. Due to the emergence of ANTIVIRAL DRUG RESISTANCE when used alone, it is administered in combination with other ANTI-HIV AGENTS.

In vivo

Vipadenant (0.3-30 mg/kg) produces a dose-dependent reduction in catalepsy. Vipadenant (10 mg/kg) does not produce any statistically significant dyskinetic episodes in 6-OHDA-lesioned rats during a 19-day dosing regimen[1]. In the mouse and rat haloperidol-induced hypolocomotion models, vipadenant has a minimum effective dose of 0.1 and 1 mg/kg, respectively. Vipadenant (3 and 10 mg/kg, p.o.) is able to increase contralateral rotations in 6-OHDA lesioned rats[2].

Synonyms	TMC114
Molecular Weight	547.66
Formula	C27H37N3O7S
CAS No.	206361-99-1

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

Ethanol: 35 mg/mL (78.14 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Fujimoto H, et al. Biol Pharm Bull, 2009, 32(9), 1588-1593.

Dose Conversion

You can also refer to dose conversion for different animals. More

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Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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The answer of 19.713 mg appears in the Mass box

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What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
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The answer of 100 microliter (0.1 ml) appears in the Volume (start) box

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Darunavir 206361-99-1 Microbiology/Virology Proteases/Proteasome HIV Protease AID TMC-114 Minimal TMC114 TMC 114 cytotoxicity UIC 94017 Human immunodeficiency virus UIC94017 Inhibitor inhibit HIV UIC-94017 inhibitor

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