Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Dehydroaltenusin is a selective eukaryotic DNA polymerase α inhibitor and a type of antibiotic produced by a fungus (IC50: 0.68 μM). Dehydroaltenusin inhibits mammalian pol α activity.
Pack Size | Availability | Price/USD | Quantity |
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25 mg | Inquiry | $ 1,520.00 |
Description | Dehydroaltenusin is a selective eukaryotic DNA polymerase α inhibitor and a type of antibiotic produced by a fungus (IC50: 0.68 μM). Dehydroaltenusin inhibits mammalian pol α activity. |
Targets&IC50 | DNA polymerase α:0.68 μM |
In vitro | Dehydroaltenusin (38.0 μM; 6 hours) inhibits cell growth by blocking the S-phase of DNA replication. Dehydroaltenusin (38.0-44.4 μM; 24 hours) inhibits cell growth in a dose-dependent manner (LD50s: 38.0 to 44.4 μM). Dehydroaltenusin (75.0 μM; 24 hours) has a potent apoptotic effect on human cancer cells, DNA ladders can be detected after 12 h of incubation with dehydroaltenusin. |
In vivo | Dehydroaltenusin possesses anti-tumor activity against human adenocarcinoma tumors in vivo. Dehydroaltenusin (injection; 20 mg/kg; 2-day intervals; 12-39 days) shows suppressed tumor growth from 21 days. |
Molecular Weight | 288.255 |
Formula | C15H12O6 |
CAS No. | 31186-13-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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Dehydroaltenusin 31186-13-7 Cell Cycle/Checkpoint DNA Damage/DNA Repair DNA/RNA Synthesis inhibitor inhibit