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Divalproex Sodium

Catalog No. T6474 CAS 76584-70-8

Synonyms: Valproate semisodium, Epival

Divalproex Sodium (Valproate semisodium) binds to and inhibits gamma-aminobutyric acid (GABA) transaminase and its anticonvulsant activity may be exerted by increasing brain concentration of GABA and by inhibiting enzymes that catabolize GABA or block the reuptake of GABA into glia and nerve endings. It also is an HDAC inhibitor， Comprised of sodium valproate and valproic acid with anticonvulsant and antiepileptic activities. Divalproex may also work by suppressing repetitive neuronal firing through the inhibition of voltage-sensitive sodium channels.

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Divalproex Sodium, CAS 76584-70-8

Pack Size	Availability	Price/USD
10 mg	In stock	$ 33.00
25 mg	In stock	$ 50.00
50 mg	In stock	$ 72.00
100 mg	In stock	$ 118.00
200 mg	In stock	$ 198.00
500 mg	In stock	$ 353.00
1 mL * 10 mM (in DMSO)	In stock	$ 50.00

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Purity: 99.84%

Biological Description

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Storage & Solubility Information

Description	Divalproex Sodium (Valproate semisodium) binds to and inhibits gamma-aminobutyric acid (GABA) transaminase and its anticonvulsant activity may be exerted by increasing brain concentration of GABA and by inhibiting enzymes that catabolize GABA or block the reuptake of GABA into glia and nerve endings. It also is an HDAC inhibitor， Comprised of sodium valproate and valproic acid with anticonvulsant and antiepileptic activities. Divalproex may also work by suppressing repetitive neuronal firing through the inhibition of voltage-sensitive sodium channels.
In vitro	Divalproex sodium enhances apoptosis, IM-induced cell growth inhibition and cell cycle arrest in K562-G and K562-S cells. It enhances the inhibitory effects of IM on SIRT1 expression in K562-G and K562-S cells. Divalproex sodium enhances the effect of IM on apoptosis in K562-G cells partly through SIRT1.
In vivo	Divalproex (500 mg/kg) significantly increases dopamine (DA) and acetylcholine (ACh) efflux in the rat hippocampus, and DA, but not ACh, efflux in the rat medial prefrontal cortex (mPFC), whereas 50 mg/kg has no effect on DA or ACh in either region. Divalproex (50 mg/kg) combined with the atypical APDs Olanzapine (1.0 mg/kg) or Aripiprazole (0.3 mg/kg) significantly potentiates the effect of both antipsychotic drugs (APDs) on DA, but not ACh efflux in the HIP and mPFC.

Synonyms	Valproate semisodium, Epival
Molecular Weight	310.41
Formula	C8H16O2·C8H15O2·Na
CAS No.	76584-70-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 57 mg/mL (183.6 mM)

DMSO: 58 mg/mL (186.8 mM)

Ethanol: 58 mg/mL (186.8 mM)

References and Literature

1. Wang W, et al. Cancer Lett, 2015, 356(2 Pt B), 791-799. 2. Huang M, et al. Brain Res, 2006, 1099(1), 44-55.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Approved Drug Library Inhibitor Library Drug Repurposing Compound Library Anti-Cancer Drug Library Traditional Chinese Medicine Monomer Library Anti-Cancer Clinical Compound Library Anti-Breast Cancer Compound Library Ion Channel Inhibitor Library NF-κB Signaling Compound Library FDA-Approved Drug Library

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Keywords

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