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Eravacycline dihydrochloride

Catalog No. T11227L CAS 1334714-66-7

Synonyms: TP-434-046, TP-434 dihydrochloride

Eravacycline dihydrochloride (TP-434-046) is a potent and broad-spectrum antibacterial agent against six E. coli (MICs: 0.125-0.25 mg/L).

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Eravacycline dihydrochloride Chemical Structure

Eravacycline dihydrochloride, CAS 1334714-66-7

Pack Size	Availability	Price/USD
1 mg	In stock	$ 197.00
5 mg	In stock	$ 690.00
10 mg	In stock	$ 872.00
25 mg	In stock	$ 1,990.00
50 mg	In stock	$ 2,680.00
100 mg	In stock	$ 3,590.00

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Purity: 100%

Purity: 95%

Purity: 94.31%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Eravacycline dihydrochloride (TP-434-046) is a potent and broad-spectrum antibacterial agent against six E. coli (MICs: 0.125-0.25 mg/L).
In vitro	Eravacycline shows inhibitory activity against A. baumannii, including isolates that are resistant to sulbactam, SM 7338, and BAY 41-6551(MIC50/90 = 0.5/1 mg/L)[1]. Eravacycline shows potent broad-spectrum activity against 90% of the isolates for all species panels (MIC90 0.008-2 μg/mL) except those of Pseudomonas aeruginosa and Burkholderia cenocepacia (MIC90 = 32 μg/mL). Eravacycline is active against multidrug-resistant bacteria including β-lactamases and antibiotics, including carbapenem resistance[4].
In vivo	Eravacycline(3.125-50 mg/kg) shows mean fAUC/MIC magnitude associated with net stasis and 1-log kill endpoint of 27.97 and 32.60[2]. In mouse septicemia models, Eravacycline is efficacious against Staphylococcus aureus and demonstrates 50% protective dose values of ≤1 mg/kg. The PD50s are 1.2-4.4 mg/kg against Escherichia coli isolates[5].

Synonyms	TP-434-046, TP-434 dihydrochloride
Molecular Weight	631.48
Formula	C27H33Cl2FN4O8
CAS No.	1334714-66-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 135.0 mg/mL (213.8 mM), Sonication is recommended.

H2O: 45.0 mg/mL (71.3 mM), Sonication is recommended.

References and Literature

1. Seifert H, et al. In-vitro activity of the novel fluorocycline eravacycline against carbapenem non-susceptible Acinetobacter baumannii. Int J Antimicrob Agents. 2017 Jul 10. 2. Zhao M, et al. In Vivo Pharmacodynamic Target Assessment of Eravacycline against Escherichia coli in a Murine Thigh Infection Model. Antimicrob Agents Chemother. 2017 Jun 27;61(7). 3. Xiao XY, et al. Fluorocyclines: a potent, broad spectrum antibacterial agent. J Med Chem. 2012 Jan 26;55(2):597-605. 4. Sutcliffe JA, et al. Antibacterial activity of eravacycline (TP-434), a novel fluorocycline, against hospital and community pathogens. Antimicrob Agents Chemother. 2013 Nov;57(11):5548-58. 5. Grossman TH, et al. Eravacycline (TP-434) is efficacious in animal models of infection. Antimicrob Agents Chemother. 2015 May;59(5):2567-71.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Approved Drug Library Anti-Cancer Drug Library Anti-Cancer Active Compound Library Anti-Cancer Clinical Compound Library EMA Approved Drug Library Drug Repurposing Compound Library Bioactive Compounds Library Max Bioactive Compound Library Approved Drug Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Eravacycline dihydrochloride 1334714-66-7 Microbiology/Virology Antibacterial TP-434 TP-434-046 TP 434 Dihydrochloride TP 434 Eravacycline Eravacycline Dihydrochloride TP-434 Dihydrochloride TP434 Dihydrochloride TP-434 dihydrochloride TP434 inhibitor inhibit

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